Search Results - "Klein, John R"

Dynamic Interactions Between the Immune System and the Neuroendocrine System in Health and Disease by Klein, John R

“…The immune system and the neuroendocrine system share many common features. Both consist of diverse components consisting of receptors and networks that are…”
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Novel Splicing of Immune System Thyroid Stimulating Hormone β-Subunit-Genetic Regulation and Biological Importance by Klein, John R

“…Thyroid stimulating hormone (TSH), a glycoprotein hormone produced by the anterior pituitary, controls the production of thyroxine (T ) and triiodothyronine (T…”
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Selective upregulation of microRNA expression in peripheral blood leukocytes in IL-10-/- mice precedes expression in the colon by Schaefer, Jeremy S, Montufar-Solis, Dina, Vigneswaran, Nadarajah, Klein, John R

“…IL-10(-/-) mice, an animal model of Th1-mediated inflammatory bowel disease, were screened for the expression of 600 microRNAs (miRNAs) using colonic tissues…”
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Splenic Leukocytes Traffic to the Thyroid and Produce a Novel TSHβ Isoform during Acute Listeria monocytogenes Infection in Mice by Montufar-Solis, Dina, Klein, John R

“…The thyroid stimulating hormone beta-subunit (TSHβ) with TSHα form a glycoprotein hormone that is produced by the anterior pituitary in the…”
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Biological Impact of the TSHβ Splice Variant in Health and Disease by Klein, John R

“…Thyroid stimulating hormone (TSH), a glycoprotein hormone composed of α and β chains, is produced by thyrotrope cells of the anterior pituitary. Within the…”
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Small intestine inflammation in Roquin-mutant and Roquin-deficient mice by Schaefer, Jeremy S, Montufar-Solis, Dina, Nakra, Niyati, Vigneswaran, Nadarajah, Klein, John R

“…Roquin, an E3 ubiquitin ligase that localizes to cytosolic RNA granules, is involved in regulating mRNA stability and translation. Mice that have a M199R…”
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ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10−/− mice by Schaefer, Jeremy S., Montufar‐Solis, Dina, Vigneswaran, Nadarajah, Klein, John R.

“…IL‐23 and IL‐10 have opposing effects on IL‐17 synthesis by mouse ICOS+ T cells in the colonic epithelium. In the absence of IL‐10, colonic inflammation…”
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Massive but selective cytokine dysregulation in the colon of IL-10−/− mice revealed by multiplex analysis by Montufar-Solis, Dina, Schaefer, Jeremy, Hicks, M. John, Klein, John R.

“…IL-10-deficient mice develop enterocolitis due to a failure of cytokine regulation; however, the full scope of that response remains poorly defined. Using…”
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The immune system as a regulator of thyroid hormone activity by Klein, John R

“…It has been known for decades that the neuroendocrine system can both directly and indirectly influence the developmental and functional activity of the immune…”
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Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection by Weber, Austin, Pawar, Hitesh N., Klein, John R.

“…•The TSHβ splice variant (TSHβv) is expressed in lymphoid precursors, monocyte precursors, and granulocyte precursors in the bone marrow.•TSHβv is…”
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Differentially Expressed Genes in Dental Pulp Tissues of Individuals With Symptomatic Irreversible Pulpitis With and Without History of COVID-19 by Cho, Han Na, Chaves de Souza, Leticia, Johnson, Cleverick, Klein, John R., Kirkpatrick, Timothy C., Silva, Renato, Letra, Ariadne

“…Increased levels of proinflammatory markers have been reported in tissues of individuals with Coronavirus Disease 2019 (COVID-19). We hypothesize that inflamed…”
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MicroRNA signatures differentiate Crohn's disease from ulcerative colitis by Schaefer, Jeremy S, Attumi, Taraq, Opekun, Antone R, Abraham, Bincy, Hou, Jason, Shelby, Harold, Graham, David Y, Streckfus, Charles, Klein, John R

“…Excessive and inappropriate immune responses are the hallmark of several autoimmune disorders, including the inflammatory bowel diseases (IBD): Crohn's disease…”
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Fluctuations of cycles in a finite CW complex by Catanzaro, Michael J., Chernyak, Vladimir Y., Klein, John R.

“…We use algebraic topology to study the stochastic motion of cellular cycles in a finite CW complex. Inspired by statistical mechanics, we introduce a…”
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The ``fundamental theorem'' for the algebraic K-theory of spaces. III. The nil-term by Klein, John R., Williams, E. Bruce

“…In this paper we identify the ``nil-terms'' for Waldhausen's algebraic K-theory of spaces functor as the reduced K-theory of a category of equivariant spaces…”
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Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice by Montufar-Solis, Dina, Williams, Alexander, Vigneswaran, Nadarajah, Klein, John R.

“…Roquin is an E3 ligase that regulates mRNA stability. Mice with a mutation in the Rc3h1 gene and Roquin protein, referred to as Roquinsan/san or sanroque mice,…”
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Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets by Montufar-Solis, Dina, Wang, Heuy-Ching, Klein, John R

“…This study has examined the stimulatory and costimulatory effects of IL‐18 on two subsets of murine small intestinal intraepithelial lymphocytes (IELs) defined…”
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On embeddings in the sphere by Klein, John R.

“…We consider embeddings of a finite complex in a sphere. We give a homotopy-theoretic classification of such embeddings in a wide range…”
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Moduli of suspension spectra by Klein, John R.

“…For a 1-connected spectrum E, we study the moduli space of suspension spectra which come equipped with a weak equivalence to E. We construct a spectral…”
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A role for IL-10 in the transcriptional regulation of Roquin-1 by Schaefer, Jeremy S., Montufar-Solis, Dina, Klein, John R.

“…Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulator of inflammation; however, nothing is known about how Rc3h1 expression is regulated. Here,…”
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T-cell activation in the intestinal mucosa by Montufar-Solis, Dina, Garza, Tomas, Klein, John R

“…The vast majority of peripheral T cells exist as resting lymphocytes until a signal for activation has been received. In response to antigen, this activation…”
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