Search Results - "Klein, H. G."

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia by Sandhöfer, N, Metzeler, K H, Rothenberg, M, Herold, T, Tiedt, S, Groiß, V, Carlet, M, Walter, G, Hinrichsen, T, Wachter, O, Grunert, M, Schneider, S, Subklewe, M, Dufour, A, Fröhling, S, Klein, H-G, Hiddemann, W, Jeremias, I, Spiekermann, K

“…In acute myeloid leukemia (AML), several signaling pathways such as the phosphatidylinositol-3-kinase/AKT and the mammalian target of rapamycin (PI3K/AKT/mTOR)…”
Get full text

Pathogen inactivation technology: cleansing the blood supply by KLEIN, H. G.

“…  Klein HG (The Johns Hopkins School of Medicine and Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA). Pathogen…”
Get full text

Immunomodulatory aspects of transfusion : A once and future risk? by KLEIN, H. G

Get full text

Allogeneic transfusion risks in the surgical patient by Klein, Harvey G.

“…The risk of blood transfusion-associated complications has been reduced in the past 10 years through technical advances in testing of blood, viral inactivation…”
Get full text

Preparation of granulocyte concentrates by apheresis: collection modalities in the USA by Strauss, R. G., Klein, H. G., Leitman, S. F., Price, T. H., Lichtiger, B., Martinez, F., Reesink, H. W., Panzer, S.

Get full text

Patient‐specific transfusion‐related acute lung injury by Muniz, M., Sheldon, S., Schuller, R. M., Young, N. S., Klein, H. G., Leitman, S. F., Stroncek, D. F.

“…Transfusion‐related acute lung injury (TRALI) is one of the leading causes of transfusion‐associated mortality. The inadvertent transfusion of neutrophil…”
Get full text

The Prospects for Red-Cell Substitutes by Klein, Harvey G

“…Blood is still the best thing possible to have in our veins, according to Woody Allen, and that is certainly the case when the blood is our own. We are not so…”
Get full text

Red blood cell transfusion in the treatment and management of anaemia: the search for the elusive transfusion trigger by Wang, J. K., Klein, H. G.

“…Therapeutic red blood cell (RBC) transfusion is widely utilized in the management of anaemia. Critically ill intensive care unit (ICU) patients in particular,…”
Get full text

Will Blood Transfusion Ever Be Safe Enough? by Klein, Harvey G

“…Klein comments on the safety of blood transfusions in the US, noting that, by and large, the protective system against infection that is currently in place has…”
Get full text

Transfusion of recently donated (fresh) red blood cells (RBCs) does not improve survival in comparison with current practice, while safety of the oldest stored units is yet to be established: a meta-analysis by Remy, K. E., Sun, J., Wang, D., Welsh, J., Solomon, S. B., Klein, H. G., Natanson, C., Cortés-Puch, I.

“…Background and Objectives Preclinical studies generated the hypothesis that older stored red blood cells (RBCs) can increase transfusion risks. To examine the…”
Get full text

Blood substitutes: how close to a solution? by Klein, H G

“…The term "blood substitute" is commonly misused when "red cell substitute (RCS) is meant. The ideal RCS should deliver (i) oxygen; (ii) require no…”
Get more information

Risks of restrictive red blood cell transfusion strategies in patients with cardiovascular disease (CVD): a meta‐analysis by Cortés‐Puch, I., Wiley, B. M., Sun, J., Klein, H. G., Welsh, J., Danner, R. L., Eichacker, P. Q., Natanson, C.

“…SUMMARY Aim To evaluate the risks of restrictive red blood cell transfusion strategies (haemoglobin 7–8 g dL−1) in patients with and without known…”
Get full text

Current status of solvent/detergent-treated frozen plasma by Klein, HG, Dodd, RY, Dzik, WH, Luban, NL, Ness, PM, Pisciotto, P, Schiff, PD, Snyder, EL

Get full text

OC-2b: Estimating the potential benefit of low-molecular-weight heparin in M2/ANXA5 haplotype carriers with recurrent pregnancy loss: a secondary analysis of the ETHIG II trial by Rogenhofer, N, Markoff, A, Wagner, A, Klein, H.-G, Petroff, D, Schleussner, E, Thaler, C.J

Get full text

International Forum regarding practices related to donor haemoglobin and iron by Goldman, M., Magnussen, K., Gorlin, J., Lozano, M., Speedy, J., Keller, A., Pink, J., Leung, J. N. S., Chu, C. C. Y., Lee, C.-K., Faed, J., Chay, J., Tan, H. H., Teo, D., Djoudi, R., Woimant, G., Fillet, A.-M., Castrén, J., Miflin, G., Vandewalle, G. C., Compernolle, V., Cardenas, J. M., Infanti, L., Holbro, A., Buser, A., van den Hurk, K., Yahalom, V. J., Gendelman, V., Shinar, E., Eder, A. F., Steele, W. R., O'Neill, E. M., Kamel, H., Vassallo, R., Delage, G., Lebrun, A., Robillard, P., Germain, M., Gandhi, M., West, K. A., Klein, H. G.

Get full text

Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation by BERGSTEN, P, AMITAI, G, KEHRL, J, DHARIWAL, K. R, KLEIN, H. G, LEVINE, M

“…Ascorbic acid (vitamin C) was found in isolated human mononuclear leukocytes and their purified components in millimolar concentration. Intracellular ascorbic…”
Get full text

Immunologic aspects of blood transfusion by Klein, H G

“…For 20 years, clinical reports and laboratory observations have suggested that allogeneic blood transfusion effects important changes in the recipient's immune…”
Get more information

A Controlled Comparison of the Efficacy of Hetastarch and Pentastarch in Granulocyte Collections by Centrifugal Leukapheresis by Lee, J.-H., Leitman, S.F., Klein, H.G.

“…Compared with hetastarch (HS), the low molecular weight analog pentastarch (PS) has been reported to be equally effective for granulocyte collection by…”
Get full text

Will blood transfusion ever be safe enough? by Klein, H. G.

Get full text

Earthquake in America by Klein, Harvey G.

Get full text