Search Results - "Klein, E E"

An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine by Whirl‐Carrillo, Michelle, Huddart, Rachel, Gong, Li, Sangkuhl, Katrin, Thorn, Caroline F., Whaley, Ryan, Klein, Teri E.

“…Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the…”
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Radical transformation or technological intervention? Two paths for universal basic income by Fouksman, E., Klein, E.

“…•We explore the complexity of a basic income trial for First Nations people in Australia.•We examine the class and racial implications of Silicon Valley basic…”
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CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network by Relling, MV, Klein, TE

“…The slow rate at which pharmacogenetic tests are being adopted in clinical practice is partly due to the lack of specific guidelines on how to adjust…”
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A gut-brain neural circuit for nutrient sensory transduction by Kaelberer, Melanie Maya, Buchanan, Kelly L, Klein, Marguerita E, Barth, Bradley B, Montoya, Marcia M, Shen, Xiling, Bohórquez, Diego V

“…The brain is thought to sense gut stimuli only via the passive release of hormones. This is because no connection has been described between the vagus and the…”
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics‐Guided Warfarin Dosing: 2017 Update by Johnson, JA, Caudle, KE, Gong, L, Whirl‐Carrillo, M, Stein, CM, Scott, SA, Lee, MT, Gage, BF, Kimmel, SE, Perera, MA, Anderson, JL, Pirmohamed, M, Klein, TE, Limdi, NA, Cavallari, LH, Wadelius, M

“…This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin…”
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The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database by Gaedigk, Andrea, Ingelman‐Sundberg, Magnus, Miller, Neil A., Leeder, J. Steven, Whirl‐Carrillo, Michelle, Klein, Teri E.

“…The Human Cytochrome P450 (CYP) Allele Nomenclature Database, a critical resource for the pharmacogenetics and genomics communities, has transitioned to the…”
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Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release by Younts, Thomas J., Monday, Hannah R., Dudok, Barna, Klein, Matthew E., Jordan, Bryen A., Katona, István, Castillo, Pablo E.

“…Long-term changes of neurotransmitter release are critical for proper brain function. However, the molecular mechanisms underlying these changes are poorly…”
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Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine: Barriers and Solutions by Klein, Michelle E, Parvez, Md Masud, Shin, Jae-Gook

“…Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which improves the efficacy, safety, and cost-effectiveness of treatments…”
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Structures of Degradation Products and Degradation Pathways of Aflatoxin B1 by High-Voltage Atmospheric Cold Plasma (HVACP) Treatment by Shi, Hu, Cooper, Bruce, Stroshine, Richard L, Ileleji, Klein E, Keener, Kevin M

“…High-voltage atmospheric cold plasma (HVACP) is a novel nonthermal decontamination technology that has potential for use in the food industry. In this study,…”
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The prevalence of age-related eye diseases and visual impairment in aging: current estimates by Klein, Ronald, Klein, Barbara E K

“…To examine prevalence of five age-related eye conditions (age-related cataract, AMD, open-angle glaucoma, diabetic retinopathy [DR], and visual impairment) in…”
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A Survey of Energy-Efficient Techniques for 5G Networks and Challenges Ahead by Buzzi, Stefano, Chih-Lin I, Klein, Thierry E., Poor, H. Vincent, Chenyang Yang, Zappone, Alessio

“…After about a decade of intense research, spurred by both economic and operational considerations, and by environmental concerns, energy efficiency has now…”
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Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron by Bell, GC, Caudle, KE, Whirl‐Carrillo, M, Gordon, RJ, Hikino, K, Prows, CA, Gaedigk, A, Agundez, JAG, Sadhasivam, S, Klein, TE, Schwab, M

“…5-hydroxytryptamine type 3 (5-HT 3 ) receptor antagonists are used in the prevention of chemotherapy- induced, radiation-induced and postoperative nausea and…”
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Pharmacogene Variation Consortium: A Global Resource and Repository for Pharmacogene Variation by Gaedigk, Andrea, Casey, Scott T., Whirl‐Carrillo, Michelle, Miller, Neil A., Klein, Teri E.

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Antimalarial drug resistance: a review of the biology and strategies to delay emergence and spread by Klein, E.Y

“…Abstract The emergence of resistance to former first-line antimalarial drugs has been an unmitigated disaster. In recent years, artemisinin class drugs have…”
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype by Crews, K R, Gaedigk, A, Dunnenberger, H M, Klein, T E, Shen, D D, Callaghan, J T, Kharasch, E D, Skaar, T C

“…Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine as an…”
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Pharmacogenomics Knowledge for Personalized Medicine by Whirl-Carrillo, M, McDonagh, E M, Hebert, J M, Gong, L, Sangkuhl, K, Thorn, C F, Altman, R B, Klein, T E

“…The Pharmacogenomics Knowledgebase (PharmGKB) is a resource that collects, curates, and disseminates information about the impact of human genetic variation on…”
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PharmGKB: A worldwide resource for pharmacogenomic information by Barbarino, Julia M., Whirl‐Carrillo, Michelle, Altman, Russ B., Klein, Teri E.

“…As precision medicine becomes increasingly relevant in healthcare, the field of pharmacogenomics (PGx) also continues to gain prominence in the clinical…”
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Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set by Klein, E.A., Richards, D., Cohn, A., Tummala, M., Lapham, R., Cosgrove, D., Chung, G., Clement, J., Gao, J., Hunkapiller, N., Jamshidi, A., Kurtzman, K.N., Seiden, M.V., Swanton, C., Liu, M.C.

“…A multi-cancer early detection (MCED) test used to complement existing screening could increase the number of cancers detected through population screening,…”
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ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG) by Miller, David T., Lee, Kristy, Chung, Wendy K., Gordon, Adam S., Herman, Gail E., Klein, Teri E., Stewart, Douglas R., Amendola, Laura M., Adelman, Kathy, Bale, Sherri J., Gollob, Michael H., Harrison, Steven M., Hershberger, Ray E., McKelvey, Kent, Richards, C. Sue, Vlangos, Christopher N., Watson, Michael S., Martin, Christa Lese

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update by Amstutz, Ursula, Henricks, Linda M., Offer, Steven M., Barbarino, Julia, Schellens, Jan H.M., Swen, Jesse J., Klein, Teri E., McLeod, Howard L., Caudle, Kelly E., Diasio, Robert B., Schwab, Matthias

“…The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the…”
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