Search Results - "Klein, Anders B."

Blood BDNF concentrations reflect brain-tissue BDNF levels across species by Klein, Anders B., Williamson, Rebecca, Santini, Martin A., Clemmensen, Christoffer, Ettrup, Anders, Rios, Maribel, Knudsen, Gitte M., Aznar, Susana

“…Brain-derived neurotrophic factor (BDNF) is involved in synaptic plasticity, neuronal differentiation and survival of neurons. Observations of decreased serum…”
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Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise by Klein, Anders B., Nicolaisen, Trine S., Ørtenblad, Niels, Gejl, Kasper D., Jensen, Rasmus, Fritzen, Andreas M., Larsen, Emil L., Karstoft, Kristian, Poulsen, Henrik E., Morville, Thomas, Sahl, Ronni E., Helge, Jørn W., Lund, Jens, Falk, Sarah, Lyngbæk, Mark, Ellingsgaard, Helga, Pedersen, Bente K., Lu, Wei, Finan, Brian, Jørgensen, Sebastian B., Seeley, Randy J., Kleinert, Maximilian, Kiens, Bente, Richter, Erik A., Clemmensen, Christoffer

“…Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like…”
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Regulating Prefrontal Cortex Activation: An Emerging Role for the 5-HT2A Serotonin Receptor in the Modulation of Emotion-Based Actions? by Aznar, Susana, Klein, Anders B.

“…The prefrontal cortex (PFC) is involved in mediating important higher-order cognitive processes such as decision making, prompting thereby our actions. At the…”
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Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation by Lundsgaard, Anne-Marie, Fritzen, Andreas M., Nicolaisen, Trine S., Carl, Christian S., Sjøberg, Kim A., Raun, Steffen H., Klein, Anders B., Sanchez-Quant, Eva, Langer, Jakob, Ørskov, Cathrine, Clemmensen, Christoffer, Tschöp, Matthias H., Richter, Erik A., Kiens, Bente, Kleinert, Maximilian

“…Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolism by increasing the oxidation of FAs over glucose…”
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Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice by Clemmensen, Christoffer, Smajilovic, Sanela, Madsen, Andreas N, Klein, Anders B, Holst, Birgitte, Bräuner-Osborne, Hans

“…The recently identified G protein-coupled receptor GPRC6A is activated by dietary amino acids and expressed in multiple tissues. Although the receptor is…”
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Transient activation of mTOR following forced treadmill exercise in rats by Elfving, Betina, Christensen, Tina, Ratner, Cecilia, Wienecke, Jacob, Klein, Anders B.

“…ABSTRACT The beneficial effect of exercise on hippocampal plasticity is possibly mediated by increased angiogenesis and neurogenesis. In angiogenesis,…”
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GDF15 in Appetite and Exercise: Essential Player or Coincidental Bystander? by Klein, Anders B, Kleinert, Maximilian, Richter, Erik A, Clemmensen, Christoffer

“…Growth differentiation factor 15 (GDF15) has recently moved to the forefront of metabolism research. When administered pharmacologically, GDF15 reduces food…”
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Enhanced voluntary wheel running in GPRC6A receptor knockout mice by Clemmensen, Christoffer, Pehmøller, Christian, Klein, Anders B, Ratner, Cecilia, Wojtaszewski, Jørgen F.P, Bräuner-Osborne, Hans

“…Abstract GPRC6A is an amino acid-sensing receptor highly expressed in the brain and in skeletal muscle. Although recent evidence suggests that genetically…”
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GHB receptor targets in the CNS: Focus on high-affinity binding sites by Bay, Tina, Eghorn, Laura F., Klein, Anders B., Wellendorph, Petrine

“…γ-Hydroxybutyric acid (GHB) is an endogenous compound in the mammalian brain with both low- and high-affinity receptor targets. GHB is used clinically in the…”
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Metabotropic glutamate receptor 2 and corticotrophin-releasing factor receptor-1 gene expression is differently regulated by BDNF in rat primary cortical neurons by Jørgensen, Christinna V., Klein, Anders B., EL-Sayed, Mona, Knudsen, Gitte M., Mikkelsen, Jens D.

“…ABSTRACT Brain‐derived neurotrophic factor (BDNF) is important for neuronal survival and plasticity. Incorporation of matured receptor proteins is an integral…”
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Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2 by Holm, Stephanie, Husted, Anna S, Skov, Louise J, Morville, Thomas H, Hagemann, Christoffer A, Jorsal, Tina, Dall, Morten, Jakobsen, Alexander, Klein, Anders B, Treebak, Jonas T, Knop, Filip K, Schwartz, Thue W, Clemmensen, Christoffer, Holst, Birgitte

“…IntroductionLiver-expressed antimicrobial peptide-2 (LEAP2) is an endogenous ghrelin receptor antagonist, which is upregulated in the fed state and…”
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Growth Differentiation Factor 15 during pregnancy and postpartum as captured in blood, cerebrospinal fluid and placenta: A cohort study on associations with maternal mental health by Høgh, Stinne, Borgsted, Camilla, Hegaard, Hanne K., Renault, Kristina M., Ekelund, Kim, Bruzzone, Silvia EP, Clemmensen, Christoffer, Klein, Anders B., Frokjaer, Vibe G.

“…Growth Differentiation Factor 15 (GDF15) increases substantially during pregnancy and is primarily produced by the placenta. Elevated levels of GDF15 have been…”
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The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance by Klein, Anders B., Nicolaisen, Trine S., Johann, Kornelia, Fritzen, Andreas M., Mathiesen, Cecilie V., Gil, Cláudia, Pilmark, Nanna S., Karstoft, Kristian, Blond, Martin B., Quist, Jonas S., Seeley, Randy J., Færch, Kristine, Lund, Jens, Kleinert, Maximilian, Clemmensen, Christoffer

“…Metformin is a blood-glucose-lowering medication with physiological effects that extend beyond its anti-diabetic indication. Recently, it was reported that…”
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GLP-1-directed NMDA receptor antagonism for obesity treatment by Petersen, Jonas, Ludwig, Mette Q., Juozaityte, Vaida, Ranea-Robles, Pablo, Svendsen, Charlotte, Hwang, Eunsang, Kristensen, Amalie W., Fadahunsi, Nicole, Lund, Jens, Breum, Alberte W., Mathiesen, Cecilie V., Sachs, Luisa, Moreno-Justicia, Roger, Rohlfs, Rebecca, Ford, James C., Douros, Jonathan D., Finan, Brian, Portillo, Bryan, Grose, Kyle, Petersen, Jacob E., Trauelsen, Mette, Feuchtinger, Annette, DiMarchi, Richard D., Schwartz, Thue W., Deshmukh, Atul S., Thomsen, Morten B., Kohlmeier, Kristi A., Williams, Kevin W., Pers, Tune H., Frølund, Bente, Strømgaard, Kristian, Klein, Anders B., Clemmensen, Christoffer

“…The N -methyl- d -aspartate (NMDA) receptor is a glutamate-activated cation channel that is critical to many processes in the brain. Genome-wide association…”
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Thyroid hormone receptor α in skeletal muscle is essential for T3‐mediated increase in energy expenditure by Nicolaisen, Trine S., Klein, Anders B., Dmytriyeva, Oksana, Lund, Jens, Ingerslev, Lars R., Fritzen, Andreas M., Carl, Christian S., Lundsgaard, Anne‐Marie, Frost, Mikkel, Ma, Tao, Schjerling, Peter, Gerhart‐Hines, Zachary, Flamant, Frederic, Gauthier, Karine, Larsen, Steen, Richter, Erik A., Kiens, Bente, Clemmensen, Christoffer

“…Thyroid hormones are important for homeostatic control of energy metabolism and body temperature. Although skeletal muscle is considered a key site for thyroid…”
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GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain by Leurs, Ulrike, Klein, Anders B., McSpadden, Ethan D., Griem-Krey, Nane, Solbak, Sara M. Ø., Houlton, Josh, Villumsen, Inge S., Vogensen, Stine B., Hamborg, Louise, Gauger, Stine J., Palmelund, Line B., Larsen, Anne Sofie G., Shehata, Mohamed A., Kelstrup, Christian D., Olsen, Jesper V., Bach, Anders, Burnie, Robert O., Kerr, D. Steven, Gowing, Emma K., Teurlings, Selina M. W., Chi, Chris C., Gee, Christine L., Frølund, Bente, Kornum, Birgitte R., van Woerden, Geeske M., Clausen, Rasmus P., Kuriyan, John, Clarkson, Andrew N., Wellendorph, Petrine

“…Ca2+/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) is a key neuronal signaling protein and an emerging drug target. The central hub domain…”
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The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα by Griem-Krey, Nane, Klein, Anders B, Clausen, Bettina H, Namini, Mathias RJ, Nielsen, Pernille V, Bhuiyan, Mozammel, Nagaraja, Raghavendra Y, De Silva, T Michael, Sobey, Christopher G, Cheng, Heung-Chin, Orset, Cyrille, Vivien, Denis, Lambertsen, Kate L, Clarkson, Andrew N, Wellendorph, Petrine

“…Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a major contributor to physiological and pathological glutamate-mediated Ca2+ signals, and its…”
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Striatal dopamine transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration by Ziebell, Morten, Khalid, Usman, Klein, Anders B, Aznar, Susana, Thomsen, Gerda, Jensen, Peter, Knudsen, Gitte M

“…Abstract Compelling evidence has shown, that neurotrophins responsible for the regulation of neuronal growth, survival, and differentiation are involved in…”
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Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity by Jall, Sigrid, De Angelis, Meri, Lundsgaard, Anne-Marie, Fritzen, Andreas M., Nicolaisen, Trine S., Klein, Anders B., Novikoff, Aaron, Sachs, Stephan, Richter, Erik A., Kiens, Bente, Schramm, Karl-Werner, Tschöp, Matthias H., Stemmer, Kerstin, Clemmensen, Christoffer, Müller, Timo D., Kleinert, Maximilian

“…Aims/hypothesis Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose…”
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Enhanced prefrontal serotonin 2A receptor signaling in the subchronic phencyclidine mouse model of schizophrenia by Santini, Martin A., Ratner, Cecilia, Aznar, Susana, Klein, Anders B., Knudsen, Gitte M., Mikkelsen, Jens D.

“…Prefrontal serotonin 2A receptors (5‐HT2ARs) have been linked to the pathogenesis and treatment of schizophrenia. Many antipsychotics fully occupy 5‐HT2AR at…”
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