Search Results - "Kleiman, Frida E"

Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability by Alonso, Alejandra D, Cohen, Leah S, Corbo, Christopher, Morozova, Viktoriya, ElIdrissi, Abdeslem, Phillips, Greg, Kleiman, Frida E

“…Tau is a neuronal microtubule associated protein whose main biological functions are to promote microtubule self-assembly by tubulin and to stabilize those…”
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Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response by Murphy, Michael R, Ramadei, Anthony, Doymaz, Ahmet, Varriano, Sophia, Natelson, Devorah M, Yu, Amy, Aktas, Sera, Mazzeo, Marie, Mazzeo, Michael, Zakusilo, George, Kleiman, Frida E

“…Alternative Polyadenylation (APA) is an emerging mechanism for dynamic changes in gene expression. Previously, we described widespread APA occurrence in…”
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Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells by Varriano, Sophia, Yu, Amy, Xu, Yu Qing, Natelson, Devorah M, Ramadei, Anthony, Kleiman, Frida E

“…The estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target…”
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To polyadenylate or to deadenylate: That is the question by Zhang, Xiaokan, Virtanen, Anders, Kleiman, Frida E.

“…mRNA polyadenylation and deadenylation are important processes that allow rapid regulation of gene expression in response to different cellular conditions…”
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Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression by Baquero, Jorge, Varriano, Sophia, Ordonez, Martha, Kuczaj, Pawel, Murphy, Michael R, Aruggoda, Gamage, Lundine, Devon, Morozova, Viktoriya, Makki, Ali Elhadi, Alonso, Alejandra Del C, Kleiman, Frida E

“…While nuclear tau plays a role in DNA damage response (DDR) and chromosome relaxation, the mechanisms behind these functions are not fully understood. Here, we…”
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BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II by Kleiman, Frida E, Wu-Baer, Foon, Fonseca, Danae, Kaneko, Syuzo, Baer, Richard, Manley, James L

“…Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this…”
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PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells by Zhang, Xiaokan, Devany, Emral, Murphy, Michael R., Glazman, Galina, Persaud, Mirjana, Kleiman, Frida E.

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PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells by Zhang, Xiaokan, Devany, Emral, Murphy, Michael R, Glazman, Galina, Persaud, Mirjana, Kleiman, Frida E

“…mRNA deadenylation is under the control of cis-acting regulatory elements, which include AU-rich elements (AREs) and microRNA (miRNA) targeting sites, within…”
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Multiple Properties of the Splicing Repressor SRp38 Distinguish It from Typical SR Proteins by Shin, Chanseok, Kleiman, Frida E., Manley, James L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response by Fonseca, Danae, Baquero, Jorge, Murphy, Michael R., Aruggoda, Gamage, Varriano, Sophia, Sapienza, Carmen, Mashadova, Oksana, Rahman, Shadaqur, Kleiman, Frida E.

“…The cellular response to DNA damage is an intricate mechanism that involves the interplay among several pathways. In this study, we provide evidence of the…”
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Epigenome-Wide Study Identifies Epigenetic Outliers in Normal Mucosa of Patients with Colorectal Cancer by Ghosh, Jayashri, Schultz, Bryant M, Chan, Joe, Wultsch, Claudia, Singh, Rajveer, Shureiqi, Imad, Chow, Stephanie, Doymaz, Ahmet, Varriano, Sophia, Driscoll, Melissa, Muse, Jennifer, Kleiman, Frida E, Krampis, Konstantinos, Issa, Jean-Pierre J, Sapienza, Carmen

“…Nongenetic predisposition to colorectal cancer continues to be difficult to measure precisely, hampering efforts in targeted prevention and screening…”
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Deadenylation and its regulation in eukaryotic cells by Zhang, Xiaokan, Kleiman, Frida E, Devany, Emral

“…Messenger RNA deadenylation is a process that allows rapid regulation of gene expression in response to different cellular conditions. The change of the mRNA…”
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Nuclear deadenylation/polyadenylation factors regulate 3′ processing in response to DNA damage by Cevher, Murat A, Zhang, Xiaokan, Fernandez, Sully, Kim, Sergey, Baquero, Jorge, Nilsson, Per, Lee, Sean, Virtanen, Anders, Kleiman, Frida E

“…We previously showed that mRNA 3′ end cleavage reaction in cell extracts is strongly but transiently inhibited under DNA‐damaging conditions. The cleavage…”
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Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA by Devany, Emral, Park, Ji Yeon, Murphy, Michael R, Zakusilo, George, Baquero, Jorge, Zhang, Xiaokan, Hoque, Mainul, Tian, Bin, Kleiman, Frida E

“…The DNA damage response involves coordinated control of gene expression and DNA repair. Using deep sequencing, we found widespread changes of alternative…”
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Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase by Chen, Angus, Kleiman, Frida E., Manley, James L., Ouchi, Toru, Pan, Zhen-Qiang

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3' processing factor CstF functions in the DNA repair response by Mirkin, Nurit, Fonseca, Danae, Mohammed, Samia, Cevher, Murat A, Manley, James L, Kleiman, Frida E

“…Following DNA damage, mRNA levels decrease, reflecting a coordinated interaction of the DNA repair, transcription and RNA processing machineries. In this…”
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Connections between 3′-end processing and DNA damage response by Cevher, Murat A., Kleiman, Frida E.

“…The cellular DNA damage response (DDR) involves changes in the functional and structural properties of a number of nuclear proteins, resulting in a coordinated…”
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Functional Interaction of BRCA1-Associated BARD1 with Polyadenylation Factor CstF-50 by Kleiman, Frida E., Manley, James L.

“…Polyadenylation of messenger RNA precursors requires a complex protein machinery that is closely integrated with the even more complex transcriptional…”
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Epigenome-wide study identifies epigenetic outliers in normal mucosa of colorectal cancer patients by Ghosh, Jayashri, Schultz, Bryant M., Chan, Joe, Wultsch, Claudia, Singh, Rajveer, Shureiqi, Imad, Chow, Stephanie, Doymaz, Ahmet, Varriano, Sophia, Driscoll, Melissa, Muse, Jennifer, Kleiman, Frida E., Krampis, Konstantinos, Issa, Jean-Pierre J., Sapienza, Carmen

“…Non-genetic predisposition to colorectal cancer (CRC) continues to be difficult to measure precisely, hampering efforts in targeted prevention and screening…”
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The BARD1-CstF-50 Interaction Links mRNA 3′ End Formation to DNA Damage and Tumor Suppression by Kleiman, Frida E., Manley, James L.

“…The mRNA polyadenylation factor CstF interacts with the BRCA1-associated protein BARD1, and this interaction represses the nuclear mRNA polyadenylation…”
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