Search Results - "Kleijmeer, Monique J"

The Biogenesis and Functions of Exosomes by Stoorvogel, Willem, Kleijmeer, Monique J., Geuze, Hans J., Raposo, Graça

“…Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many cell types into the extracellular milieu. They correspond to the internal…”
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Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells by Hegmans, Joost P.J.J., Bard, Martin P.L., Hemmes, Annabrita, Luider, Theo M., Kleijmeer, Monique J., Prins, Jan-Bas, Zitvogel, Laurence, Burgers, Sjaak A., Hoogsteden, Henk C., Lambrecht, Bart N.

“…Exosomes are small membrane vesicles secreted into the extracellular compartment by exocytosis. Tumor exosomes may be involved in the sampling of antigens to…”
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Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation by Strik, Merel C.M., de Koning, Pieter J.A., Kleijmeer, Monique J., Bladergroen, Bellinda A., Wolbink, Angela M., Griffith, Janice M., Wouters, Dorine, Fukuoka, Yoshihiro, Schwartz, Lawrence B., Hack, C. Erik, van Ham, S. Marieke, Kummer, J. Alain

“…Mast cells are widely distributed throughout the body and express effector functions in allergic reactions, inflammatory diseases, and host defense. Activation…”
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Involvement of the endoplasmic reticulum in peroxisome formation by Geuze, Hans J, Murk, Jean Luc, Stroobants, An K, Griffith, Janice M, Kleijmeer, Monique J, Koster, Abraham J, Verkleij, Arie J, Distel, Ben, Tabak, Henk F

“…The traditional view holds that peroxisomes are autonomous organelles multiplying by growth and division. More recently, new observations have challenged this…”
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MHC Class II Compartments in Human Dendritic Cells Undergo Profound Structural Changes Upon Activation by Barois, Nicolas, De Saint‐Vis, Blandine, Lebecque, Serge, Geuze, Hans J., Kleijmeer, Monique J.

“…Immature dendritic cells efficiently capture exogenous antigens in peripheral tissues. In an inflammatory environment, dendritic cells are activated and become…”
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Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments by Kleijmeer, Monique J., Morkowski, Stanislaw, Griffith, Janice M., Rudensky, Alexander Y., Geuze, Hans J.

“…In most human and mouse antigen-presenting cells, the majority of intracellular major histocompatibility complex (MHC) class II molecules resides in late…”
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Immature Human Dendritic Cells Express Asialoglycoprotein Receptor Isoforms for Efficient Receptor-Mediated Endocytosis by Valladeau, Jenny, Duvert-Frances, Valerie, Pin, Jean-Jacques, Kleijmeer, Monique J, Ait-Yahia, Smina, Ravel, Odile, Vincent, Claude, Vega, Felix, Jr, Helms, Alison, Gorman, Dan, Zurawski, Sandra M, Zurawski, Gerard, Ford, John, Saeland, Sem

“…In a search for genes expressed by dendritic cells (DC), we have cloned cDNAs encoding different forms of an asialoglycoprotein receptor (ASGPR). The DC-ASGPR…”
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Association of Tapasin and COPI Provides a Mechanism for the Retrograde Transport of Major Histocompatibility Complex (MHC) Class I Molecules from the Golgi Complex to the Endoplasmic Reticulum by Paulsson, Kajsa M., Kleijmeer, Monique J., Griffith, Janice, Jevon, Marc, Chen, Shangwu, Anderson, Per O., Sjögren, Hans-Olov, Li, Suling, Wang, Ping

“…Tapasin is a subunit of the transporter associated with antigen processing (TAP). It associates with the major histocompatibility complex (MHC) class I. We…”
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Exosome: from internal vesicle of the multivesicular body to intercellular signaling device by Denzer, K, Kleijmeer, M J, Heijnen, H F, Stoorvogel, W, Geuze, H J

“…Exosomes are small membrane vesicles that are secreted by a multitude of cell types as a consequence of fusion of multivesicular late endosomes/lysosomes with…”
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Location of MHC-encoded transporters in the endoplasmic reticulum and cis -Golgi by Kleijmeer, Monique J, Kelly, Adrian, Geuze, Hans J, Slot, Jan W, Townsend, Alain, Trowsdale, John

“…Immune recognition of intracellular proteins is mediated by major histocompatibility complex (MHC) class I molecules that present short peptides to cytotoxic T…”
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Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface by Denzer, Kristin, van Eijk, Marco, Kleijmeer, Monique J, Jakobson, Eva, de Groot, Cornelis, J. Geuze, Hans

“…Follicular dendritic cells (FDCs) present in lymphoid follicles play a critical role in germinal center reactions. They trap native Ags in the form of immune…”
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Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes by Escola, Jean-Michel, Kleijmeer, Monique J., Stoorvogel, Willem, Griffith, Janice M., Yoshie, Osamu, Geuze, Hans J.

“…Association of major histocompatibility complex (MHC) class II molecules with peptides occurs in a series of endocytic vacuoles, termed MHC class II-enriched…”
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Cathepsin S Controls MHC Class II-Mediated Antigen Presentation by Epithelial Cells In Vivo by Beers, Courtney, Burich, Andrew, Kleijmeer, Monique J, Griffith, Janice M, Wong, Phillip, Rudensky, Alexander Y

“…Epithelial cells at environmental interfaces provide protection from potentially harmful agents, including pathogens. In addition to serving as a physical…”
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Thymocyte expression of cathepsin L is essential for NKT cell development by Rudensky, Alexander Y, Honey, Karen, Benlagha, Kamel, Beers, Courtney, Forbush, Katherine, Teyton, Luc, Kleijmeer, Monique J, Bendelac, Albert

“…CD1d antigen presentation to natural killer T (NKT) cells expressing the semi-invariant T cell receptor V(alpha)14J(alpha)18 requires CD1d trafficking through…”
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Spatial organization of the transforming MHC class II compartment by van tot Pannerden, Hezder E. Nispen, Geerts, Willie J., Kleijmeer, Monique J., Heijnen, Harry F.G.

“…Background information. DC (dendritic cells) continuously capture pathogens and process them into small peptides within the endolysosomal compartment, the MIIC…”
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The plasticity of multivesicular bodies and the regulation of antigen presentation by Murk, Jean-Luc, Stoorvogel, Willem, Kleijmeer, Monique J, Geuze, Hans J

“…Multivesicular bodies (MVBs) are ubiquitous endocytic organelles containing numerous 50–80 nm vesicles. MVBs are very dynamic in shape and function. In antigen…”
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Accumulation of HLA-DM, a Regulator of Antigen Presentation, in MHC Class II Compartments by Sanderson, Frances, Kleijmeer, Monique J., Kelly, Adrian, Verwoerd, Desirée, Tulp, Abraham, Neefjes, Jacques J., Geuze, Hans J., Trowsdale, John

“…The HLA-DM genes encode an unconventional HLA (human leukocyte antigen) class II molecule that is required for appropriate binding of peptide to classical HLA…”
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Antigen Loading of MHC Class I Molecules in the Endocytic Tract by Kleijmeer, Monique J., Escola, Jean‐Michel, UytdeHaag, Fons G.C.M., Jakobson, Eva, Griffith, Janice M., Osterhaus, Albert D.M.E., Stoorvogel, Willem, Melief, Cornelis J.M., Rabouille, Catherine, Geuze, Hans J.

“…Major histocompatibility complex (MHC) class I molecules bind antigenic peptides that are translocated from the cytosol into the endoplasmic reticulum by the…”
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3‐D Structure of Multilaminar Lysosomes in Antigen Presenting Cells Reveals Trapping of MHC II on the Internal Membranes by Murk, Jean‐Luc A. N., Lebbink, Misjaël N., Humbel, Bruno M., Geerts, Willie J. C., Griffith, Janice M., Langenberg, Dennis M. L., Verreck, Frank A. W., Verkleij, Arie J., Koster, Abraham J., Geuze, Hans J., Kleijmeer, Monique J.

“…In late endosomes and lysosomes of antigen presenting cells major histocompatibility complex class II (MHC II) molecules bind peptides from degraded…”
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Characterization of MHC Class II Compartments by Immunoelectron Microscopy by Kleijmeer, Monique J., Raposo, Graça, Geuze, Hans J.

“…At present the best way to determine the precise intracellular localization of proteins, in a potentially semiquantitative way, is the combination of ultrathin…”
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