Search Results - "Kleifeld, O."

Towards third generation matrix metalloproteinase inhibitors for cancer therapy by OVERALL, C. M, KLEIFELD, O

“…The failure of matrix metalloproteinase (MMP) inhibitor drug clinical trials in cancer was partly due to the inadvertent inhibition of MMP antitargets that…”
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Biological control of the root-knot nematode Meloidogyne javanica by Trichoderma harzianum by SHARON, E, BAR-EYAL, M, CHET, I, HERRERA-ESTRELLA, A, KLEIFELD, O, SPIEGEL, Y

“…ABSTRACT The fungal biocontrol agent, Trichoderma harzianum, was evaluated for its potential to control the root-knot nematode Meloidogyne javanica. In…”
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Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase by Au, A E-L, Sashindranath, M, Borg, R J, Kleifeld, O, Andrews, R K, Gardiner, E E, Medcalf, R L, Samson, A L

“…Platelet activation is a frontline response to injury, not only essential for clot formation but also important for tissue repair. Indeed, the reparative…”
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Active site electronic structure and dynamics during metalloenzyme catalysis by Sagi, Irit, Kleifeld, Oded, Frenkel, Anatoly, Martin, Jan M.L

“…Zinc-dependent enzymes play important roles in many cellular processes. Assignment of their reaction mechanisms is often a subject of debate because the zinc…”
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Trichoderma harzianum – interaction with plants and effect on growth response by KLEIFELD, O., CHET, I.

“…The fungus Trichoderma harzianum which was applied to pathogen-free soil, induced an increase in emergence of seedlings, plant height, leaf area and dry…”
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Structural Basis for Potent Slow Binding Inhibition of Human Matrix Metalloproteinase-2 (MMP-2) by Rosenblum, Gabriel, Meroueh, Samy O., Kleifeld, Oded, Brown, Stephen, Singson, Steven P., Fridman, Rafael, Mobashery, Shahriar, Sagi, Irit

“…The zinc-dependent gelatinases belong to the family of matrix metalloproteinases (MMPs), enzymes that have been shown to play a key role in angiogenesis and…”
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Higher Metal−Ligand Coordination in the Catalytic Site of Cobalt-Substituted Thermoanaerobacter brockii Alcohol Dehydrogenase Lowers the Barrier for Enzyme Catalysis by Kleifeld, Oded, Rulíšek, Lubomír, Bogin, Oren, Frenkel, Anatoly, Havlas, Zdeněk, Burstein, Yigal, Sagi, Irit

“…Thermoanaerobacter brockii alcohol dehydrogenase (TbADH) is a zinc-dependent NADP+/H-linked class enzyme that reversibly catalyzes the oxidation of secondary…”
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Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy by Overall, Christopher M, Kleifeld, Oded

“…The matrix metalloproteinases (MMPs) mediate homeostasis of the extracellular environment. They have multiple signalling activities that are commonly altered…”
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Observations in the treatment of the human eye with ultrasonics by KLEIFELD, O

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X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme by Kleifeld, O, Kotra, L P, Gervasi, D C, Brown, S, Bernardo, M M, Fridman, R, Mobashery, S, Sagi, I

“…Malignant tumors express high levels of zinc-dependent endopeptidases called matrix metalloproteinases (MMPs), which are thought to facilitate tumor metastasis…”
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The conserved Glu‐60 residue in Thermoanaerobacter brockii alcohol dehydrogenase is not essential for catalysis by Kleifeld, Oded, Shi, Shu Ping, Zarivach, Raz, Eisenstein, Miriam, Sagi, Irit

“…Glu‐60 of the zinc‐dependent Thermoanaerobacter brockii alcohol dehydrogenase (TbADH) is a strictly conserved residue in all members of the alcohol…”
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Spectroscopic Studies of Inhibited Alcohol Dehydrogenase from Thermoanaerobacter brockii: Proposed Structure for the Catalytic Intermediate State by Kleifeld, Oded, Frenkel, Anatoly, Bogin, Oren, Eisenstein, Miriam, Brumfeld, Vlad, Burstein, Yigal, Sagi, Irit

“…Thermoanaerobacter brockii alcohol dehydrogenase (TbADH) catalyzes the reversible oxidation of secondary alcohols to the corresponding ketones using NADP+ as…”
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Isoform-specific effects of apolipoprotein E on secretion of the amyloid precursor protein by Oron, L., Kleifeld, O., Michaelson, D.M.

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Time-dependent XAS studies of trapped enzyme-substrate complexes of alcohol dehydrogenase from Thermoanaerobacter brockii by Kleifeld, O, Frenkel, A, Sagi, I

“…The understanding of structure-function relationships in proteins has been significantly advanced with the advent of the biotechnological revolution. A goal…”
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Structural Characterization of the Catalytic Active Site in the Latent and Active Natural Gelatinase B from Human Neutrophils by Kleifeld, Oded, Van den Steen, Philippe E., Frenkel, Anatoly, Cheng, Feng, Jiang, Hua Liang, Opdenakker, Ghislain, Sagi, Irit

“…Matrix metalloproteinases are endopeptidases that have a leading role in the catabolism of the macromolecular components of the extracellular matrix in a…”
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Time resolved X-ray absorption spectroscopy studies of metalloenzymes reveal mechanistic information beyond kinetics by Sagi, I., Rosenblum, G., Kleifeld, O., Frenkel, A.

“…Abstract only…”
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The phosphorus metabolism in the lens by ARENS, H P, DARDENNE, U, FUCHS, R, HOCKWIN, O, KLEIFELD, O, MULLER, H K

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Oxygen content of human aqueous humor after artificial respiration by KLEIFELD, O, HOCKWIN, O

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On the treatment of senile cataract with debenal by MUELLER, H K, KLEIFELD, O

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The oxygen content of human aqueous humor by KLEIFELD, O, NEUMANN, H G

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