Search Results - "Klei, Thomas R"

From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis by Klei, Thomas R L, Meinderts, Sanne M, van den Berg, Timo K, van Bruggen, Robin

“…Erythropoiesis is a highly regulated process where sequential events ensure the proper differentiation of hematopoietic stem cells into, ultimately, red blood…”
Get full text

Establishment of macrocyclic lactone resistant Dirofilaria immitis isolates in experimentally infected laboratory dogs by Pulaski, Cassan N, Malone, John B, Bourguinat, Catherine, Prichard, Roger, Geary, Timothy, Ward, Danielle, Klei, Thomas R, Guidry, Tal, Smith, George ‘Bud’, Delcambre, Brooke, Bova, Jonathan, Pepping, Jenny, Carmichael, James, Schenker, Rudolf, Pariaut, Romain

“…BACKGROUND: Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to macrocyclic lactone (ML) preventive drugs have been increasingly reported in…”
Get full text

Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection by Arumugam, Sridhar, Wei, Junfei, Liu, Zhuyun, Abraham, David, Bell, Aaron, Bottazzi, Maria Elena, Hotez, Peter J, Zhan, Bin, Lustigman, Sara, Klei, Thomas R

“…The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for…”
Get full text

The Onchocerciasis Vaccine for Africa--TOVA--Initiative by Hotez, Peter J, Bottazzi, Maria Elena, Zhan, Bin, Makepeace, Benjamin L, Klei, Thomas R, Abraham, David, Taylor, David W, Lustigman, Sara

“…  According to a recent analysis in PLOS Neglected Tropical Diseases, between 1995 and 2010, APOC averted more than 8.2 million disability-adjusted life years…”
Get full text

Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils by Zhan, Bin, Arumugam, Sridhar, Kennedy, Malcolm W, Tricoche, Nancy, Lian, Lu-Yun, Asojo, Oluwatoyin A, Bennuru, Sasisekhar, Bottazzi, Maria Elena, Hotez, Peter J, Lustigman, Sara, Klei, Thomas R

“…Parasitic nematodes produce an unusual class of fatty acid and retinol (FAR)-binding proteins that may scavenge host fatty acids and retinoids. Two FARs from…”
Get full text

The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice by Hess, Jessica A, Zhan, Bin, Torigian, April R, Patton, John B, Petrovsky, Nikolai, Zhan, Tingting, Bottazzi, Maria Elena, Hotez, Peter J, Klei, Thomas R, Lustigman, Sara, Abraham, David

“…In some regions in Africa, elimination of onchocerciasis may be possible with mass drug administration, although there is concern based on several factors that…”
Get full text

Recommendations for in vitro evaluation of blood components collected, prepared and stored in non‐DEHP medical devices by Klei, Thomas R. L., Begue, Stephane, Lotens, Anaïs, Sigurjónsson, Ólafur E., Wiltshire, Michael D., George, Chloë, Burg, Peter J. M., Evans, Ryan, Larsson, Linda, Thomas, Stephen, Najdovski, Tome, Handke, Wiebke, Eronen, Juha, Mallas, Birte, Korte, Dirk

“…Background and Objectives DEHP, di(2‐ethylhexyl) phthalate, is the most common member of the class of ortho‐phthalates, which are used as plasticizers. The…”
Get full text

Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells by Meinderts, Sanne M., Oldenborg, Per-Arne, Beuger, Boukje M., Klei, Thomas R.L., Johansson, Johanna, Kuijpers, Taco W., Matozaki, Takashi, Huisman, Elise J., de Haas, Masja, van den Berg, Timo K., van Bruggen, Robin

“…Red blood cell (RBC) clearance is known to occur primarily in the spleen, and is presumed to be executed by red pulp macrophages. Erythrophagocytosis in the…”
Get full text

New Method for Simultaneous Species-Specific Identification of Equine Strongyles (Nematoda, Strongylida) by Reverse Line Blot Hybridization by Traversa, Donato, Iorio, Raffaella, Klei, Thomas R, Kharchenko, Vitaliy A, Gawor, Jakub, Otranto, Domenico, Sparagano, Olivier A.E

“…The ability of a reverse line blot (RLB) assay to identify 13 common species of equine small strongyles (cyathostomins) and to discriminate them from three…”
Get full text

Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae by Arumugam, Sridhar, Zhan, Bin, Abraham, David, Ward, Danielle, Lustigman, Sara, Klei, Thomas R

“…BACKGROUND: Cysteine protease inhibitors of Brugia malayi have been ascribed to be involved in parasite development as well as to immunomodulate the host’s…”
Get full text

Allogeneic Serum Eye Drops: A Randomized Clinical Trial to Evaluate the Clinical Effectiveness of Two Drop Sizes by Vermeulen, Christie, van der Burg, Lars L. J., van Geloven, Nan, Eggink, Catharina A., Cheng, Yanny Y. Y., Nuijts, Rudy M. M. A., Wisse, Robert P. L., van Luijk, Chantal M., Nieuwendaal, Carla, Remeijer, Lies, van der Meer, Pieter F., de Korte, Dirk, Klei, Thomas R. L.

“…Introduction Allogeneic serum from blood donors is starting to be used to treat patients with dry eye disease (DED). However, the optimal dose is not known. We…”
Get full text

Residual pyruvate kinase activity in PKLR‐deficient erythroid precursors of a patient suffering from severe haemolytic anaemia by Klei, Thomas R.L., Kheradmand Kia, Sima, Veldthuis, Martijn, Beuger, Boukje M., Geissler, Judy, Dehbozorgian, Javad, Karimi, Mehran, Bruggen, Robin, Zwieten, Rob

“…Objective Here, we present a 7‐year‐old patient suffering from severe haemolytic anaemia. The most common cause of chronic hereditary non‐spherocytic…”
Get full text

Onchocerca volvulus: The Road from Basic Biology to a Vaccine by Lustigman, Sara, Makepeace, Benjamin L., Klei, Thomas R., Babayan, Simon A., Hotez, Peter, Abraham, David, Bottazzi, Maria Elena

“…Human onchocerciasis – commonly known as river blindness – is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan…”
Get full text

Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil model by Martin, Heather R., Shakya, Krishna P., Muthupalani, Sureshkumar, Ge, Zhongming, Klei, Thomas R., Whary, Mark T., Fox, James G.

“…In select Helicobacter pylori-infected populations with low gastric cancer, nematode coinfections are common and both helicobacter gastritis and filariasis are…”
Get full text

Inflammatory Responses to Migrating Brugia pahangi Third-Stage Larvae by Porthouse, Kristina H, Chirgwin, Sharon R, Coleman, Sharon U, Taylor, H. Wayne, Klei, Thomas R

“…Despite being central to parasite establishment and subsequent host pathological and immunologic responses, host-parasite interactions during early third-stage…”
Get full text

The quality of red cells stored under blood bank conditions: Is donor age just a number? by Meer, Pieter F., Klei, Thomas R. L.

Get full text

Dirk de Korte (1955–2024) by Meer, Pieter F., Lagerberg, Johan, Klei, Thomas R. L.

Get full text

Storage properties of platelet concentrates from umbilical cord blood prepared using three different methods by Cortesi, Valeria, Lopriore, Enrico, Cavallaro, Giacomo, Bontekoe, Ido J., Meer, Pieter F., Fustolo‐Gunnink, Susanna, Raffaeli, Genny, Ghirardello, Stefano, Klei, Thomas R. L.

“…Background Thrombocytopenia, common in preterm newborns, may increase bleeding risk and is often treated with transfusions. Recent studies reveal that…”
Get full text

Red blood cells as oxygen carrier during normothermic machine perfusion of kidney grafts: Friend or foe? by Arykbaeva, Asel S., Lerink, Lente J.S., Vos, Jaël, Engelse, Marten A., van Kooten, Cees, de Korte, Dirk, Lagerberg, Johan W.M., Klei, Thomas R.L., Mulder, Aat A., Minnee, Robert C., Ploeg, Rutger J., Kers, Jesper, Moers, Cyril, Pol, Robert A., Alwayn, Ian P.J., de Vries, Dorottya K., Lindeman, Jan H.N.

“…Renal ex vivo normothermic machine perfusion (NMP) is under development as an assessment tool for high-risk kidney grafts and as a means of achieving more…”
Get full text

The effect of near-infrared low-level light on the in vitro quality of platelets during storage by Bontekoe, Ido J, van der Meer, Pieter F, de Laleijne-Liefting, Lara A E, Klei, Thomas R L

“…Near-infrared (NIR) light has been successfully applied to improve the quality of mouse platelets during storage. Because it is suspected that the mitochondria…”
Get full text