Search Results - "Kleef, U W"

Hepatobiliary disposition of vecuronium bromide in man by Bencini, A F, Scaf, A H, Sohn, Y J, Kersten-Kleef, U W, Agoston, S

“…The plasma and bile concentrations, the biliary excretion and the neuromuscular blocking effect of vecuronium bromide were studied during surgery in 13…”
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Do plasma concentrations obtained from early arterial blood sampling improve pharmacokinetic/pharmacodynamic modeling? by Beaufort, T M, Proost, J H, Kuizenga, K, Houwertjes, M C, Kleef, U W, Wierda, J M

“…In pharmacokinetic/pharmacodynamic (PK/PD) modeling the first blood sample is usually taken 1 to 2 min after drug administration (late sampling). Therefore,…”
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The pharmacokinetics, urinary and biliary excretion of pipecuronium bromide by Wierda, J M, Szenohradszky, J, De Wit, A P, Zentai, G, Agoston, S, Kakas, M, Kleef, U W, Meijer, D K

“…The pharmacodynamics and -kinetics of pipecuronium were studied in 12 patients, six of whom received 100 micrograms kg-1 for laryngectomy (Group L), and six…”
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Pharmacokinetics and Pharmacodynamics of Pipecuronium in Patients with Cirrhosis by DʼHonneur, G., Khalil, M., Dominique, C., Haberer, J. P., Kleef, U. W., Duvaldestin, P.

“…To determine the effect of liver cirrhosis on the pharmacokinetics and pharmacodynamics of pipecuronium, the authors administered 100 μg/kg of pipecuronium…”
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The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl by MARK, J, WIERDA, K. H, KLEEF, U. W, LAMBALK, L. M, KLOPPENBURG, W. D, AGOSTON, S

“…The pharmacodynamics and pharmacokinetics of a new non-depolarizing neuromuscular blocking agent, Org 9426, were investigated. Ten patients undergoing elective…”
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Preliminary investigations of the clinical pharmacology of three short-acting non-depolarizing neuromuscular blocking agents, Org 9453, Org 9489 and Org 9487 by WIERDA, J. M. K. H, BEAUFORT, A. M, KLEEF, U. W, SMEULERS, N. J, AGOSTON, S

“…Three muscle relaxants, Org 9453, Org 9489 and Org 9487, short-acting in animals, were investigated to establish their profiles in humans. Potency, time course…”
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Determination of rocuronium and its putative metabolites in body fluids and tissue homogenates by Kleef, U W, Proost, J H, Roggeveld, J, Wierda, J M

“…A sensitive and selective HPLC method was developed for the quantification of the neuromuscular blocking agent rocuronium and its putative metabolites (the…”
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The influence of hypothermia (surface cooling) on the time-course of action and on the pharmacokinetics of rocuronium in humans by Beaufort, A M, Wierda, J M, Belopavlovic, M, Nederveen, P J, Kleef, U W, Agoston, S

“…Hypothermia prolongs the time-course of action of non-depolarizing neuromuscular blocking agents. The mechanism, however, is unknown. We studied the influence…”
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Pharmacokinetics and cardiovascular dynamics of pipecuronium bromide during coronary artery surgery by WIERDA, J. M. K. H, KARLICZEK, G. F, VANDENBROM, R. H. G, PINTO, I, KERSTEN-KLEEF, U. W, MEIJER, D. K. F, AGOSTON, S

“…The haemodynamic effects of 200 micrograms.kg-1 pipecuronium and pancuronium were compared under etomidate/piritramide anaesthesia in 20 patients scheduled for…”
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The isolated heart-lung preparation in the cat. An in situ model to study the role of the lungs in the disposition of drugs by Beaufort, A M, Wierda, J M, Houwertjes, M C, Kleef, U W, Meijer, D K

“…In the search for drugs with an extreme short time course of action, compounds should be developed that are rapidly distributed to and temporarily stored in…”
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PHARMACOKINETICS AND CARDIOVASCULAR EFFECTS OF PIPECURONIUM BROMIDE (ARDUAN) IN C.A.B.G. PATIENTS by Wierda, J. M.K.H., Karliczek, G. F., van den Brom, R. H.G., Kersten-Kleef, U. W., Agoston, S.

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