Search Results - "Klee, CB"

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin by Klee, Claude B., Ren, Hao, Wang, Xutong

“…The role of protein phosphatases in the regulation of cellular processes is now well established. Calcineurin (also called protein phosphatase 2B), a major…”
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Solution structure of calcium-free calmodulin by Kuboniwa, Hitoshi, Tjandra, Nico, Grzesiek, Stephan, Ren, Hao, Klee, Claude B, Bax, Ad

“…The three-dimensional structure of calmodulin in the absence of Ca2+ has been determined by three- and four-dimensional heteronuclear NMR experiments,…”
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Superoxide dismutase protects calcineurin from inactivation by Wang, X, Culotta, V C, Klee, C B

“…Calcineurin is the only protein phosphatase known to be under the control of Ca2+ and calmodulin. It is targeted by immunosuppressive drugs and has a critical…”
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Calcineurin: from structure to function by Aramburu, J, Rao, A, Klee, C B

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Dual Calcium Ion Regulation of Calcineurin by Calmodulin and Calcineurin B by Stemmer, Paul M, Klee, Claude B

“…The dependence of calcineurin on Ca2+ for activity is the result of the concerted action of calmodulin, which increases the turnover rate of the enzyme and…”
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Solution Structure of a Calmodulin-Target Peptide Complex by Multidimensional NMR by Ikura, Mitsuhiko, Clore, G. Marius, Gronenborn, Angela M., Zhu, Guang, Klee, Claude B., Bax, Ad

“…The three-dimensional solution structure of the complex between calcium-bound calmodulin (Ca$^{2+}$-CaM) and a 26-residue synthetic peptide comprising the CaM…”
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Low Affinity Ca2+-Binding Sites of Calcineurin B Mediate Conformational Changes in Calcineurin A by Yang, Seun-Ah, Klee, Claude B

“…Limited proteolysis of calcineurin in the presence of Ca2+ suggested that its calmodulin-binding domain, readily degraded by proteases, was unfolded while…”
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Calcium Dependence of the Interaction between Calmodulin and Anthrax Edema Factor by Ulmer, Tobias S., Soelaiman, Sandriyana, Li, Shipeng, Klee, Claude B., Tang, Wei-Jen, Bax, Ad

“…Edema factor (EF), a toxin from Bacillus anthracis (anthrax), possesses adenylyl cyclase activity and requires the ubiquitous Ca2+-sensor calmodulin (CaM) for…”
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Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity by Liu, J, Albers, M. W, Wandless, T. J, Luan, S, Alberg, D. G, Belshaw, P. J, Cohen, P, MacKintosh, C, Klee, C. B, Schreiber, S. L

“…Calcineurin, a Ca2+, calmodulin-dependent protein phosphatase, was recently found to bind with high affinity to two different immunosuppressant binding…”
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Keeping up with calcium: conference on calcium-binding proteins and calcium function in health and disease by Klee, Claude B, Means, Anthony R

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Inhibition of Neutrophil Chemokinesis on Vitronectin by Inhibitors of Calcineurin by Hendey, Bill, Klee, Claude B., Maxfield, Frederick R.

“…Migration of human polymorphonuclear neutrophils on vitronectin is dependent on repeated transient increases in the concentration of intracellular free calcium…”
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Concerted regulation of protein phosphorylation and dephosphorylation by calmodulin by KLEE, C. B

“…The multiple functions of calmodulin in brain bring to light an apparent paradox in the mechanism of action of this multifunctional regulatory protein: How can…”
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There Is Communication between All Four Ca2+-Bindings Sites of Calcineurin B by Gallagher, Stephen C, Gao, Zhong-Hua, Li, Shipeng, Dyer, R. Brian, Trewhella, Jill, Klee, Claude B

“…We have used site-directed mutagenesis, flow dialysis, and Fourier transform infrared (FTIR) spectroscopy to study Ca2+-binding to the regulatory component of…”
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Measurement of Calcineurin Phosphatase Activity in Cell Extracts by Fruman, David A., Pai, Sung-Yun, Klee, Claude B., Burakoff, Steven J., Bierer, Barbara E.

“…The calmodulin-dependent phosphatase calcineurin is an important molecular target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. Complexes of…”
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Functional domain structure of calcineurin A: mapping by limited proteolysis by Hubbard, Michael J, Klee, Claude B

“…Limited proteolysis of calcineurin, the Ca2+/calmodulin-stimulated protein phosphatase, with clostripain is sequential and defines four functional domains in…”
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Isotope-edited multidimensional NMR of calcineurin B in the presence of the non-deuterated detergent CHAPS by Anglister, J, Grzesiek, S, Ren, H, Klee, C B, Bax, A

“…At the concentration needed for NMR, the calcium-saturated form of calcineurin B dissolved in water shows resonance line widths that indicate aggregation of…”
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Factors responsible for the Ca2+‐dependent inactivation of calcineurin in brain by Stemmer, Paul M., Wang, Xutong, Krinks, Marie H., Klee, Claude B.

“…The Ca2+‐dependent protein phosphatase activity of crude rat brain extracts measured in the presence of okadaic acid, exhibits the characteristic properties of…”
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Identification, Characterization, and Functional Correlation of Calmodulin-Dependent Protein Phosphatase in Sperm by Tash, J. S., Krinks, M., Patel, J., Means, R. L., Klee, C. B., Means, A. R.

“…Preliminary data demonstrated that the inhibition of reactivated sperm motility by calcium was correlated with inhibited protein phosphorylation. The…”
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Calmodulin by Klee, C B, Crouch, T H, Richman, P G

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Characterization of the Lanthanide Ion-Binding Properties of Calcineurin-B Using Laser-Induced Luminescence Spectroscopy by Burroughs, Sarah E, Horrocks, William D, Ren, Hao, Klee, Claude B

“…Calcineurin (CaN) is a Ca2+/calmodulin-dependent protein phosphatase found in brain and other tissues. It is a heterodimer consisting of a catalytic subunit…”
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