Search Results - "Klecker, Raymond W"

Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice : Influence of sex and inhibitors by KLECKER, Raymond W, CYSYK, Richard L, COLLINS, Jerry M

“…To aid in the clinical evaluation of zebularine, a potential oral antitumor agent, we initiated studies on the metabolism of zebularine in liver cytosol from…”
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Pharmacogenetically driven patient selection for a first-in-human phase I trial of batracylin in patients with advanced solid tumors and lymphomas by Kummar, Shivaani, Gutierrez, Martin E., Anderson, Lawrence W., Klecker, Raymond W., Chen, Alice, Murgo, Anthony J., Doroshow, James H., Collins, Jerry M.

“…Purpose Batracylin (daniquidone), an ATP-insensitive topoisomerase I/II inhibitor, demonstrated wide interspecies variation in preclinical models consistent…”
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Glucuronidation of 3′-Azido-3′-Deoxythymidine (Zidovudine) by Human Liver Microsomes: Relevance to Clinical Pharmacokinetic Interactions with Atovaquone, Fluconazole, Methadone, and Valproic Acid by Trapnell, Carol Braun, Klecker, Raymond W., Jamis-Dow, Carlos, Collins, Jerry M.

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Metabolic profile of XK469 (2(R)-[4-(7-chloro-2-quinoxalinyl)oxyphenoxy]-propionic acid; NSC698215) in patients and in vitro: low potential for active or toxic metabolites or for drug-drug interactions by Anderson, Lawrence W, Collins, Jerry M, Klecker, Raymond W, Katki, Aspandiar G, Parchment, Ralph E, Boinpally, Ramesh R, LoRusso, Patricia M, Ivy, S Percy

“…As part of an ongoing phase 1 study, we studied the excretion of XK469 and its metabolism in patients and in vitro. Five primary metabolites were identified by…”
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Synthesis of 2′-deoxy-2′-[ 18F]fluoro-β-D-arabinofuranosyl nucleosides, [ 18F]FAU, [ 18F]FMAU, [ 18F]FBAU and [ 18F]FIAU, as potential PET agents for imaging cellular proliferation : synthesis of [ 18F]labelled FAU, FMAU, FBAU, FIAU by Mangner, Thomas J, Klecker, Raymond W, Anderson, Lawrence, Shields, Anthony F

“…An efficient and reliable synthesis of 2′-deoxy-2′-[ 18F]fluoro-β-D-arabinofuranosyl nucleosides is presented. Overall decay-corrected radiochemical yields of…”
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Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer by Rogan, Alfred M., Hamilton, Thomas C., Young, Robert C., Klecker, Raymond W., Ozols, Robert F.

“…The effectiveness of adriamycin in the treatment of ovarian cancer and other human tumors has been limited by the development of drug resistance. Verapamil, a…”
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Evaluation of highly bound drugs: interspecies, intersubject, and related comparisons by Collins, Jerry M, Klecker, Jr, Raymond W

“…Free (unbound) drug is generally the pharmacologically relevant parameter for drug exposure. Thus, comparisons among species, among individuals, and in other…”
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Radiosynthesis of [11C]paclitaxel by Ravert, Hayden T., Klecker Jr, Raymond W., Collins, Jerry M., Mathews, William B., Pomper, Martin G., Wahl, Richard L., Dannals, Robert F.

“…[11C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [α‐11C]benzoyl chloride with the primary amine precursor of paclitaxel. The…”
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Biodistribution and Radiation Dosimetry Estimates of 1-(2'-Deoxy-2'-18F-Fluoro-1-{beta}-D-Arabinofuranosyl)-5-Bromouracil: PET Imaging Studies in Dogs by Nimmagadda, Sridhar, Mangner, Thomas J, Sun, Haihao, Klecker, Raymond W., Jr, Muzik, Otto, Lawhorn-Crews, Jawana M, Douglas, Kirk A, Collins, Jerry M, Shields, Anthony F

“…This study reports on the biodistribution and radiation estimates of 1-(2'-deoxy-2'-(18)F-fluoro-1-beta-d-arabinofuranosyl)-5-bromouracil ((18)F-FBAU), a…”
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Distribution of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: Rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase by EISEMAN, Julie L, BROWN-PROCTOR, Clive, KLECKER, Raymond W, KINAHAN, Paul E, COLLINS, Jerry M, ANDERSON, Lawrence W, JOSEPH, Erin, HAMBURGER, Deborah R, PAN, Su-Shu, MATHIS, Chester A, EGORIN, Merrill J

“…In colorectal, breast, and head and neck cancers, response to 5-fluorouracil is associated with low expression of thymidylate synthase. In contrast, tumors…”
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Distribution of 1-(2-Deoxy-2-fluoro-β-d-arabinofuranosyl) Uracil in Mice Bearing Colorectal Cancer Xenografts by Eiseman, Julie L., Brown-Proctor, Clive, Kinahan, Paul E., Collins, Jerry M., Anderson, Lawrence W., Joseph, Erin, Hamburger, Deborah R., Pan, Su-shu, Mathis, Chester A., Egorin, Merrill J., Klecker, Raymond W.

“…Purpose: In colorectal, breast, and head and neck cancers, response to 5-fluorouracil is associated with low expression of thymidylate synthase. In contrast,…”
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Metabolism by N-Acetyltransferase 1 In Vitro and in Healthy Volunteers: A Prototype for Targeted Inhibition by Cantilena Jr, Louis R., Katki, Aspandiar G., Klecker, Raymond W., Collins, Jerry M.

“…Inhibition of drug metabolism is generally avoided but can be useful in limited circumstances, such as reducing the formation of toxic metabolites. Acetylation…”
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Suicide Prodrugs Activated by Thymidylate Synthase: Rationale for Treatment and Noninvasive Imaging of Tumors with Deoxyuridine Analogues by COLLINS, J. M, KLECKER, R. W, KATKI, A. G

“…Most tumors are resistant to therapy by thymidylate synthase (TS) inhibitors due to their high levels of TS. Instead of inhibiting TS, we hypothesized that it…”
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Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases by Klecker, Jr, R W, Collins, J M, Yarchoan, R, Thomas, R, Jenkins, J F, Broder, S, Myers, C E

“…We investigated the clinical pharmacokinetics of azidothymidine (N3TdR) as part of a phase I/II trial in the treatment of acquired immunodeficiency syndrome…”
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Evaluation of Highly Bound Drugs: Interspecies, Intersubject, and Related Comparisons by Collins, Jerry M., Klecker Jr, Raymond W.

“…Free (unbound) drug is generally the pharmacologically relevant param eter for drug exposure. Thus, comparisons among species, among individuals, and in other…”
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Biodistribution and radiation dosimetry estimates of 1-(2'-deoxy-2'-(18)F-Fluoro-1-beta-D-arabinofuranosyl)-5-bromouracil: PET imaging studies in dogs by Nimmagadda, Sridhar, Mangner, Thomas J, Sun, Haihao, Klecker, Jr, Raymond W, Muzik, Otto, Lawhorn-Crews, Jawana M, Douglas, Kirk A, Collins, Jerry M, Shields, Anthony F

“…This study reports on the biodistribution and radiation estimates of 1-(2'-deoxy-2'-(18)F-fluoro-1-beta-d-arabinofuranosyl)-5-bromouracil ((18)F-FBAU), a…”
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Thymidine phosphorylase as a target for imaging and therapy with thymine analogs by KLECKER, Raymond W, COLLINS, Jerry M

“…Thymidine phosphorylase (TPase; platelet-derived endothelial cell growth factor) is an attractive target for imaging and therapy because of the strong…”
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Stereoselective Metabolism of Fenoldopam and Its Metabolites in Human Liver Microsomes, Cytosol, and Slices by Klecker, Raymond W, Collins, Jerry M

“…Fenoldopam is a racemic mixture (R-FEN, S-FEN) that is a selective dopamine (DA-1) receptor agonist with pronounced cardiovascular and renal effects in humans…”
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Effect of the mutation of tyrosine 713 in p93c-fes on its catalytic activity and ability to promote myeloid differentiation in K562 cells by Fang, Fang, Ahmad, Shakeel, Lei, Jun, Klecker, Raymond W, Trepel, Jane B, Smithgall, Thomas E, Glazer, Robert I

“…The protooncogene protein-tyrosine kinase c-fes plays an active role in the induction of terminal myeloid differentiation in myeloid leukemia cells. Although…”
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Selenium-induced cytotoxicity of human leukemia cells: interaction with reduced glutathione by BATIST, G, KATKI, A. G, KLECKER, R. W. JR, MYERS, C. E

“…Selenium exists in a number of forms with differing valence states, some of which have shown antitumor activity. We studied the tumoricidal activity of four…”
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