Search Results - "Klecker, R W"

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients by Ozols, R F, Cunnion, R E, Klecker, Jr, R W, Hamilton, T C, Ostchega, Y, Parrillo, J E, Young, R C

“…Eight patients with refractory ovarian cancer were treated on a pilot protocol of verapamil plus Adriamycin (Adria Laboratories, Columbus, OH). This trial was…”
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Glucuronidation of 3′-Azido-3′-Deoxythymidine (Zidovudine) by Human Liver Microsomes: Relevance to Clinical Pharmacokinetic Interactions with Atovaquone, Fluconazole, Methadone, and Valproic Acid by Trapnell, Carol Braun, Klecker, Raymond W., Jamis-Dow, Carlos, Collins, Jerry M.

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Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy by Wilson, W H, Jamis-Dow, C, Bryant, G, Balis, F M, Klecker, R W, Bates, S E, Chabner, B A, Steinberg, S M, Kohler, D R, Wittes, R E

“…Dexverapamil is a competitive inhibitor of the P-glycoprotein (Pgp) efflux pump, a potent mechanism of multidrug resistance (mdr-1) in vitro. We performed a…”
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Rifampin and rifabutin and their metabolism by human liver esterases by JAMIS-DOW, C. A., KATKI, A. G., COLLINS, J. M., KLECKER, R. W.

“…1. The main metabolites of rifampin and rifabutin in man are their respective 25 deacetylated derivatives, but the enzyme(s) responsible for these…”
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Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases by Klecker, Jr, R W, Collins, J M, Yarchoan, R, Thomas, R, Jenkins, J F, Broder, S, Myers, C E

“…We investigated the clinical pharmacokinetics of azidothymidine (N3TdR) as part of a phase I/II trial in the treatment of acquired immunodeficiency syndrome…”
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Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer by Rogan, Alfred M., Hamilton, Thomas C., Young, Robert C., Klecker, Raymond W., Ozols, Robert F.

“…The effectiveness of adriamycin in the treatment of ovarian cancer and other human tumors has been limited by the development of drug resistance. Verapamil, a…”
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Metabolism of rifabutin and its 25-desacetyl metabolite, LM565, by human liver microsomes and recombinant human cytochrome P-450 3A4: relevance to clinical interaction with fluconazole by TRAPNELL, C. B, JAMIS-DOW, C, KLECKER, R. W, COLLINS, J. M

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Dextran sulfate is poorly absorbed after oral administration by Lorentsen, K J, Hendrix, C W, Collins, J M, Kornhauser, D M, Petty, B G, Klecker, R W, Flexner, C, Eckel, R H, Lietman, P S

“…To determine whether dextran sulfate (molecular weight, 7000 to 8000 daltons; 17% to 20% sulfur), a synthetic heparin analogue with anti-human immunodeficiency…”
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Suicide Prodrugs Activated by Thymidylate Synthase: Rationale for Treatment and Noninvasive Imaging of Tumors with Deoxyuridine Analogues by COLLINS, J. M, KLECKER, R. W, KATKI, A. G

“…Most tumors are resistant to therapy by thymidylate synthase (TS) inhibitors due to their high levels of TS. Instead of inhibiting TS, we hypothesized that it…”
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Pyrimidine dideoxyribonucleosides: selectivity of penetration into cerebrospinal fluid by Collins, J M, Klecker, Jr, R W, Kelley, J A, Roth, J S, McCully, C L, Balis, F M, Poplack, D G

“…Cerebrospinal fluid (CSF)/plasma ratios of 1 to 30% were obtained in rhesus monkeys for the 3'-azido- and 2',3'-dideoxy-analogs of thymidine, deoxycytidine and…”
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Effect of cimetidine, probenecid, and ketoconazole on the distribution, biliary secretion, and metabolism of [3H]taxol in the Sprague-Dawley rat by Klecker, R W, Jamis-Dow, C A, Egorin, M J, Erkmen, K, Parker, R J, Stevens, R, Collins, J M

“…Male Sprague-Dawley rats had their bile ducts cannulated and were dosed with [3H]taxol (2 mg/kg, 68-77 microCi/mg) as a continuous intravenous infusion for 6…”
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Metabolism of taxol by human and rat liver in vitro : a screen for drug interactions and interspecies differences by JAMIS-DOW, C. A, KLECKER, R. W, KATKI, A. G, COLLINS, J. M

“…Human liver slices, human liver microsomes, and rat liver microsomes were used to investigate the metabolism of 3H-taxol. The effects of drugs frequently…”
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Pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS and related disorders by Klecker, Jr, R W, Collins, J M, Yarchoan, R C, Thomas, R, McAtee, N, Broder, S, Myers, C E

“…The clinical pharmacokinetics of 2',3'-dideoxycytidine (DDC) were determined after oral and intravenous administration in ten patients with AIDS or…”
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Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells by Klecker, R W, Katki, A G, Collins, J M

“…Two cell lines, U-937 and MOLT-4, were used to investigate the toxicity, DNA incorporation, and effect on mitochondria of…”
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Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukemia cells is associated with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding activities by Rohlff, C, Safa, B, Rahman, A, Cho-Chung, Y S, Klecker, R W, Glazer, R I

“…8-Chloro-cyclic AMP (8-Cl-cAMP) produces growth-inhibitory and differentiating activity in the promyelocytic leukemia cell line HL-60. Adriamycin…”
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Predicting drug interactions in vivo from experiments in vitro : Human studies with paclitaxel and ketoconazole by JAMIS-DOW, C. A, PEARL, M. L, WATKINS, P. B, BLAKE, D. S, KLECKER, R. W, COLLINS, J. M

“…This study was performed to evaluate whether concomitant treatment with ketoconazole could reduce the clearance of paclitaxel given to ovarian cancer patients…”
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Clinical pharmacokinetics of suramin in patients with HTLV-III/LAV infection by Collins, J M, Klecker, Jr, R W, Yarchoan, R, Lane, H C, Fauci, A S, Redfield, R R, Broder, S, Myers, C E

“…Suramin has been reported to inhibit the reverse transcriptase activity of a number of retroviruses and to reduce the in vitro infectivity and cytopathic…”
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Thymidine phosphorylase as a target for imaging and therapy with thymine analogs by KLECKER, Raymond W, COLLINS, Jerry M

“…Thymidine phosphorylase (TPase; platelet-derived endothelial cell growth factor) is an attractive target for imaging and therapy because of the strong…”
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Selenium-induced cytotoxicity of human leukemia cells: interaction with reduced glutathione by BATIST, G, KATKI, A. G, KLECKER, R. W. JR, MYERS, C. E

“…Selenium exists in a number of forms with differing valence states, some of which have shown antitumor activity. We studied the tumoricidal activity of four…”
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Stereoselective Metabolism of Fenoldopam and Its Metabolites in Human Liver Microsomes, Cytosol, and Slices by Klecker, Raymond W, Collins, Jerry M

“…Fenoldopam is a racemic mixture (R-FEN, S-FEN) that is a selective dopamine (DA-1) receptor agonist with pronounced cardiovascular and renal effects in humans…”
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