Search Results - "Klebanoff, Seymour J."

Myeloperoxidase: friend and foe by Klebanoff, Seymour J.

“…Neutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their primary function, the phagocytosis and destruction of microorganisms…”
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Myeloperoxidase: a front-line defender against phagocytosed microorganisms by Klebanoff, Seymour J., Kettle, Anthony J., Rosen, Henry, Winterbourn, Christine C., Nauseef, William M.

“…Review of myeloperoxidase supporting optimal microbicidal activity in the phagosomes of human neutrophils. Successful immune defense requires integration of…”
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Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils by Rosen, Henry, Klebanoff, Seymour J, Wang, Yi, Brot, Nathan, Heinecke, Jay W, Fu, Xiaoyun

“…Reactive oxygen intermediates generated by neutrophils kill bacteria and are implicated in inflammatory tissue injury, but precise molecular targets are…”
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Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin by Hajjar, Adeline M, O'Mahony, D. Shane, Ozinsky, Adrian, Underhill, David M, Aderem, Alan, Klebanoff, Seymour J, Wilson, Christopher B

“…Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the…”
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Regulated expression of pathogen‐associated molecular pattern molecules in Staphylococcus epidermidis: quorum‐sensing determines pro‐inflammatory capacity and production of phenol‐soluble modulins by Vuong, Cuong, Dürr, Manuela, Carmody, Aaron B., Peschel, Andreas, Klebanoff , Seymour J., Otto, Michael

“…Summary Phenol‐soluble modulin (PSM) is a peptide complex produced by the nosocomial pathogen Staphylococcus epidermidis that has a strong capacity to activate…”
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Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA by Otto, Michael, Wang, Rong, Braughton, Kevin R, Kretschmer, Dorothee, Bach, Thanh-Huy L, Queck, Shu Y, Li, Min, Kennedy, Adam D, Dorward, David W, Klebanoff, Seymour J, Peschel, Andreas, DeLeo, Frank R

“…Methicillin-resistant Staphylococcus aureus (MRSA) remains a major human pathogen. Traditionally, MRSA infections occurred exclusively in hospitals and were…”
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Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus by Kretschmer, Dorothee, Gleske, Anne-Kathrin, Rautenberg, Maren, Wang, Rong, Köberle, Martin, Bohn, Erwin, Schöneberg, Torsten, Rabiet, Marie-Joséphe, Boulay, Francois, Klebanoff, Seymour J, van Kessel, Kok A, van Strijp, Jos A, Otto, Michael, Peschel, Andreas

“…Virulence of emerging community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and other highly pathogenic S. aureus strains depends on their…”
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Activity of Staphylococcus epidermidis phenol-soluble modulin peptides expressed in Staphylococcus carnosus by Otto, Michael, O'Mahoney, D. Shane, Guina, Tina, Klebanoff, Seymour J.

“…Staphylococcus epidermidis releases a group of peptides termed phenol-soluble modulin (PSM) that stimulate macrophages. The structure of 3 peptides (PSMα,…”
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Stimulation of human neutrophils and monocytes by staphylococcal phenol-soluble modulin by Liles, W. Conrad, Thomsen, Anni R., O’Mahony, D. Shane, Klebanoff, Seymour J.

“…Modulins represent microbial products that stimulate cytokine production in host cells. The modulins responsible for gram‐positive sepsis remain poorly…”
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Myeloperoxidase by Klebanoff, S J

“…Phagocytes respond to stimulation with a burst of oxygen consumption, and much, if not all, of the extra oxygen consumed in the respiratory burst is converted…”
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Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages by Kiener, P A, Davis, P M, Starling, G C, Mehlin, C, Klebanoff, S J, Ledbetter, J A, Liles, W C

“…Human monocytes undergo spontaneous apoptosis upon culture in vitro; removal of serum from the media dramatically increases the rate of this process. Monocyte…”
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The relationship of hydrogen peroxide-producing lactobacilli to bacterial vaginosis and genital microflora in pregnant women by Hillier, S L, Krohn, M A, Klebanoff, S J, Eschenbach, D A

“…Lactobacilli provide an important microbial defense against genital colonization by pathogens. The role of hydrogen peroxide (H2O2) in the control of genital…”
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Lactobacilli and Vaginal Host Defense: Activation of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat, Cytokine Production, and NF-κB by Klebanoff, Seymour J., Watts, D. Heather, Mehlin, Christopher, Headley, Catherine M.

“…Lactobacilli, a component of the normal vaginal flora, can activate the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR) in the Jurkat T…”
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Role of oxidants and proteases in glomerular injury by Johnson, Richard J., Lovett, David, Lehrer, Robert I., Couser, William G., Klebanoff, Seymour J.

“…During the last 10 years, there have been many major advances in our understanding of the pathogenesis of glomerular injury. Of particular significance has…”
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Cross-linking of CD18 primes human neutrophils for activation of the respiratory burst in response to specific stimuli: implications for adhesion-dependent physiological responses in neutrophils by Liles, W C, Ledbetter, J A, Waltersdorph, A W, Klebanoff, S J

“…Adhesion is known to prime neutrophils for physiological activation in response to cytokines and other stimuli. We have employed the technique of receptor…”
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Single-Cell Raman and Fluorescence Microscopy Reveal the Association of Lipid Bodies with Phagosomes in Leukocytes by van Manen, Henk-Jan, Kraan, Yvonne M., Roos, Dirk, Otto, Cees, Klebanoff, Seymour J.

“…Cellular imaging techniques based on vibrational spectroscopy have become powerful tools in cell biology because the molecular composition of subcellular…”
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The Myeloperoxidase Product Hypochlorous Acid Oxidizes HDL in the Human Artery Wall and Impairs ABCA1-Dependent Cholesterol Transport by Bergt, Constanze, Pennathur, Subramaniam, Fu, Xiaoyun, Byun, Jaeman, O'Brien, Kevin, McDonald, Thomas O., Singh, Pragya, Anantharamaiah, G. M., Chait, Alan, Brunzell, John, Geary, Randolph L., Oram, John F., Heinecke, Jay W., Klebanoff, Seymour J.

“…Although oxidatively damaged lipoproteins are implicated in vascular injury, there is little information regarding the role of high-density lipoprotein (HDL)…”
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Generation of a Neutrophil Chemotactic Agent by Spermatozoa: Role of Complement and Regulation by Seminal Plasma Factors by Clark, Robert A, Klebanoff, Seymour J

“…The interactions of polymorphonuclear leukocytes, spermatozoa, seminal plasma, and serum have been examined in an in vitro leukocyte chemotaxis system. Bovine…”
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Virucidal effect of stimulated eosinophils on human immunodeficiency virus type 1 by Klebanoff, S J, Coombs, R W

“…Eosinophils, when stimulated, release a variety of agents that can be toxic to ingested or extracellular targets. Among these systems is one that consists of…”
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Activation of the Human Immunodeficiency Virus Long Terminal Repeat in THP-1 Cells by a Staphylococcal Extracellular Product by Klebanoff, Seymour J., Kazazi, Farhad, Van Voorhis, Wesley C., Schlechte, Kristie G.

“…Staphylococcal strains can release a factor that strongly activates the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in THP-1 cells…”
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