Search Results - "Klavinskis, Linda S."
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Rationale for targeting complement in COVID‐19
Published in EMBO molecular medicine (07-08-2020)“…A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread internationally, posing a health emergency to the global community. COVID‐19 caused…”
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TCR contact residue hydrophobicity is a hallmark of immunogenic CD8⁺ T cell epitopes
Published in Proceedings of the National Academy of Sciences - PNAS (07-04-2015)“…Despite the availability of major histocompatibility complex (MHC)-binding peptide prediction algorithms, the development of T-cell vaccines against pathogen…”
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Langerin negative dendritic cells promote potent CD8⁺ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays
Published in Proceedings of the National Academy of Sciences - PNAS (19-02-2013)“…Stabilization of virus protein structure and nucleic acid integrity is challenging yet essential to preserve the transcriptional competence of live recombinant…”
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Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
Published in Nature communications (17-05-2019)“…CD8 + T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered…”
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A timely update of global COVID-19 vaccine development
Published in Emerging microbes & infections (01-01-2020)“…This commentary provides an overview and links to presentations of a recent virtual congress series organized by the International Society for Vaccines (ISV)…”
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Bacillus subtilis spores: A novel microparticle adjuvant which can instruct a balanced Th1 and Th2 immune response to specific antigen
Published in European Journal of Immunology (01-06-2007)“…There is a current need for safe, cheap, and effective vaccine adjuvants, to combine with sub‐unit antigens to enhance their immunogenicity. In this study we…”
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The human intestinal IgA response; burning questions
Published in Frontiers in immunology (01-01-2012)“…The title of this special topic invites us to identify areas in the field of IgA biology that are uncertain or in need of clarification. The inductive phase of…”
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A distinct subset of intestinal dendritic cells responds selectively to oral TLR7/8 stimulation
Published in European Journal of Immunology (01-10-2006)“…The intestinal innate immune system continually interacts with commensal bacteria, thus oral vaccines should induce extra/alternative activation of DC,…”
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Hyporesponsiveness of Intestinal Dendritic Cells to TLR Stimulation Is Limited to TLR4
Published in The Journal of immunology (1950) (15-02-2009)“…Dendritic cells (DCs) are crucial to intestinal immune regulation because of their roles in inducing protective immunity against pathogens while maintaining…”
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Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses
Published in The Journal of immunology (1950) (15-03-2011)“…It is uncertain whether NK cells modulate T cell memory differentiation. By using a genetic model that allows the selective depletion of NK cells, we show in…”
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Skin vaccination with live virus vectored microneedle arrays induce long lived CD8+ T cell memory
Published in Vaccine (08-09-2015)“…Abstract A simple dissolvable microneedle array (MA) platform has emerged as a promising technology for vaccine delivery, due to needle-free injection with a…”
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Acquisition of MHC:peptide complexes by dendritic cells contributes to the generation of antiviral CD8+ T cell immunity in vivo
Published in The Journal of immunology (1950) (01-09-2012)“…There is an increasing body of evidence suggesting that the transfer of preformed MHC class I:peptide complexes between a virus-infected cell and an uninfected…”
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Plasmacytoid Dendritic Cells Do Not Migrate in Intestinal or Hepatic Lymph
Published in Journal of Immunology (01-11-2006)“…Plasmacytoid dendritic cells (pDCs) recognize pathogen-associated molecules, particularly viral, and represent an important mechanism in innate defense. They…”
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Intranasal Immunization with Plasmid DNA-Lipid Complexes Elicits Mucosal Immunity in the Female Genital and Rectal Tracts
Published in The Journal of immunology (1950) (01-01-1999)“…The development of vaccines against pathogens transmitted across the genito-rectal mucosa that effectively stimulate both secretory IgA Abs and cytotoxic T…”
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Mucosal immunization with DNA vaccines
Published in Methods (San Diego, Calif.) (01-11-2003)“…DNA vaccines represent a new approach to the control of infectious disease. Both cellular and humoral immune responses are induced without the attendant…”
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Incorporation of immunomodulators into plasmid DNA vaccines
Published in Methods in molecular medicine (2003)Get more information
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Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope
Published in Virology (New York, N.Y.) (01-10-1990)“…The outcome of infection by lymphocytic choriomeningitis virus (LCMV) is determined largely by the cytotoxic T lymphocyte (CTL) response of the host. In H-2b…”
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Immune modulation of collagen‐induced arthritis by intranasal cytokine gene delivery: A model for the therapy of rheumatoid arthritis
Published in Arthritis and rheumatism (01-12-2005)“…Objective To develop a passively targeted, patient‐compliant, intranasal interleukin‐10 (IL‐10) gene therapy delivery system and to investigate its therapeutic…”
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Recent developments in molecular therapeutic approaches for rheumatoid arthritis
Published in Current opinion in molecular therapeutics (01-08-2004)“…Rheumatoid arthritis is a debilitating systemic autoimmune disease characterized by chronic synovial inflammation, which results in the progressive destruction…”
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Mucosal immunization with DNA-liposome complexes
Published in Vaccine (01-06-1997)“…The mucosal surfaces represent the primary site for transmission of several viruses including HIV. To prevent mucosal transmission and dissemination to the…”
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