Search Results - "Klauschenz, E."

Cellular uptake of antisense oligonucleotides after complexing or conjugation with cell‐penetrating model peptides by Oehlke, J., Birth, P., Klauschenz, E., Wiesner, B., Beyermann, M., Oksche, A., Bienert, M.

“…The uptake by mammalian cells of phosphorothioate oligonucleotides was compared with that of their respective complexes or conjugates with cationic,…”
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Cellular uptake of an α-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically by Oehlke, Johannes, Scheller, Anne, Wiesner, Burkhard, Krause, Eberhard, Beyermann, Michael, Klauschenz, Erhard, Melzig, Mathias, Bienert, Michael

“…Evidence that multiple, probably non-endocytic mechanisms are involved in the uptake into mammalian cells of the α-helical amphipathic model peptide…”
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Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling by Klussmann, Enno, Edemir, Bayram, Pepperle, Barbara, Tamma, Grazia, Henn, Volker, Klauschenz, Erhard, Hundsrucker, Christian, Maric, Kenan, Rosenthal, Walter

“…In an attempt to isolate protein kinase A anchoring proteins (AKAPs) involved in vasopressin-mediated water reabsorbtion, the complete sequence of the human…”
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Rapid assay for in vitro degradation of luteinizing hormone releasing hormone by Berger, H, Schäfer, H, Klauschenz, E, Albrecht, E, Mehlis, B

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Tritium labeling of gonadotropin releasing hormone in its proline and histidine residues by Klauschenz, E, Bienert, M, Egler, H, Pleiss, U, Niedrich, H, Nikolics, K

“…3,4-dehydroproline9-GnRH prepared by solid phase peptide synthesis was tritiated catalytically under various conditions yielding 3H-GnRH with specific…”
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Potential cardiotonics. 14. Synthesis and in vitro positive inotropic actions of 4-morpholino-5-(4-pyridinyl)pyridine derivatives by Hagen, V, Hagen, A, Krause, E G, Klauschenz, E

“…By the reaction of 2-chloro-5-(4-pyridinyl)pyridines 1-6 with morpholine as well as by derivation of the 2-morpholino-pyridine-3-carboxamide 8 the…”
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Potential cardiotonic agents. 11. Synthesis and cardiovascular effects of 5-alkyl-substituted 2-amino-3-cyano-5- -4-dyl)pyridines by Klauschenz, E, Hagen, V, Hagen, A, Heer, S

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Spin trapping using 2,2-dimethyl-2H-imidazole-1-oxides by Klauschenz, E, Haseloff, R F, Volodarskii, L B, Blasig, I E

“…The ability of novel cyclic nitrones, 4-substituted 2,2-dimethyl-2H-imidazole-1-oxides (IMO's) to trap a variety of short-lived free radicals has been…”
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X-ray structural analysis of 3 crystalline modifications of 3-cyan-5-methyl-5-(pyridinyl)-1,2-dihydro-pyrid-2-one (milrinone) by Reck, G, Hagen, V, Bannier, G, Klauschenz, E

“…The crystal and molecular structures of the alpha-, beta-, and gamma-modification of the cardiotonic compound milrinone have been determined by X-ray structure…”
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Potential cardiotonic agents. 8. 2-acyloxyalkylamino-, 2-acyloxyalkoxy-, and 2-acylaminoalkylamino-3-cyan-5-(pyrid-4-yl) pyridine by Hagen, V, Klauschenz, E, Rumler, A, Niedrich, H, Hagen, A, Heer, S, Mitzner, R

“…By acylation of our previously described cardiotonic active 2-hydroxyalkylamino, 2-hydroxyalkoxy, 2-aminoalkyl-amino and 2-piperazino substituted…”
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Potential cardiotonics. 7. Synthesis and cardiovascular effects of 5-(4-pyridinyl)-, 6-methyl-4-(4-pyridinyl) and 6-methyl-5-phenyl-substituted 3-cyano-2-aminoalkylamino-pyridines by Hagen, V, Rumler, A, Klauschenz, E, Hagen, A, Heer, S, Faust, G, Mitzner, R

“…The title compounds were synthesized by treating of 2-chloro-pyridines 1-3 with the appropriate aminoalkylamines or piperazines. In isolated guinea pig atria…”
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Potential cardiotonic agents. 6. Synthesis and cardiovascular properties of 5-(4-pyridinyl)-, 6-methyl-5-(4-pyridinyl)- and 6-methyl-5-phenyl-substituted 3-cyano-2-oxaalkyoxy-pyridines by Hagen, V, Klauschenz, E, Rumler, A, Hagen, A, Heer, S, Mitzner, R, Niedrich, H, Lohmann, D

“…The headline compounds were prepared by the reaction of 2-chloropyridines 1-3 with the appropriate alcohols in presence of potassium hydroxide and the sodium…”
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Potential cardiotonic agents. 2. Synthesis and pharmacologic properties of 5-(pyri-4-yl)- and 5-phenyl substituted 3-cyano-6-methyl-2-oxaalkylaminopyridines by Klauschenz, E, Rumler, A, Hagen, V, Hagen, A, Heer, S, Mitzner, R, Niedrich, H

“…The authors describe the preparation, the physicochemical properties and the results of evaluation of positive inotropic and vasodilator activities in a series…”
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Crystal modifications of 3-cyan-6-methyl-5-(pyrid-4-yl)-1,2-dihydropyrid-2-one (milrinone) by Klauschenz, E, Hagen, V, Gentsch, B, Niedrich, H, Dathe, M, Reck, G, Jänsch, H J

“…The preparation and characterisation of crystalline alpha-, beta- and gamma modifications of 3-cyan-6-methyl-5-(4-pyrid-4-yl)-1,2-dihydropyrid-2-on e are…”
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Some observations indicating a low brain uptake of [3H]Nle11-Substance P by Landgraf, R, Klauschenz, E, Bienert, M, Ermisch, A, Oehme, P

“…The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP)…”
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Direct tritium-labelling into histidine of luteinizing hormone-releasing hormone agonists and use of the tracers in studies on proteolytic breakdown by Bienert, M, Albrecht, E, Berger, H, Klauschenz, E, Pleiss, U, Niedrich, H, Mehlis, B

“…Analogs of luteinizing hormone-releasing hormone (LHRH) having higher biological activity than LHRH itself are being mainly used to study the biological…”
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Protection of methionine in peptides during iodination by sulfonium salt formation by Bienert, M, Klauschenz, E, Nikolics, K, Niedrich, H

“…A method for the prevention of methionine oxidation during iodination of tyrosine containing peptides is reported. The methionine containing peptide is…”
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On the blood-brain barrier to peptides: [3H]gonadotropin-releasing hormone accumulation by eighteen regions of the rat brain and by anterior pituitary by Ermisch, A, Rühle, H J, Klauschenz, E, Kretzschmar, R

“…After intracarotid injection of [3H]gonadotropin-releasing hormone ([3H]GnRH) the mean accumulation of radioactivity per unit wet weight of 18 investigated…”
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