Search Results - "Klaus, Jeffrey L."

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors by Palmer, James T, Rasnick, David, Klaus, Jeffrey L, Bromme, Dieter

Get full text

Hepatitis C NS3 protease inhibition by peptidyl-α-ketoamide inhibitors: kinetic mechanism and structure by Liu, Yaya, Stoll, Vincent S., Richardson, Paul L., Saldivar, Ayda, Klaus, Jeffrey L., Molla, Akhteruzzaman, Kohlbrenner, William, Kati, Warren M.

“…A series of novel peptidyl-α-ketoamide compounds were evaluated as inhibitors of the ΔNS3-NS4A serine protease from the hepatitis C virus. These…”
Get full text

Crystal structure of human cathepsin K complexed with a potent inhibitor by McGrath, Mary E, Klaus, Jeffrey L, Barnes, Michael G, Brömme, Dieter

“…The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the…”
Get full text

Cysteine protease activity is up‐regulated in inflamed ankle joints of rats with adjuvant‐induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor by Biroc, Sandra L., Gay, Steffen, Hummel, Klaus, Magill, Catherine, Palmer, James T., Spencer, Donna R., Sa, Susan, Klaus, Jeffrey L., Michel, Beat A., Rasnick, David, Gay, Renate E.

“…Objective Cysteine proteases are postulated to play a role in tissue destruction in the joints of animals with arthritis. The purpose of the present study was…”
Get full text

Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors by ROSENTHAL, P. J, OLSON, J. E, LEE, G. K, PALMER, J. T, KLAUS, J. L, RASNICK, D

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
Get full text

Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex by Linnevers, Christopher J., Mcgrath, Mary E., Armstrong, Andy, Mistry, Firoz R., Barnes, Michael G., Klaus, Jeffrey L., Palmer, James T., Katz, Bradley A., Brömme, Dieter

“…Cathepsin K is a cysteine protease of the papain family, which is predominantly expressed in osteoclasts, and is regarded as a key protease in bone remodeling…”
Get full text

Fluorescent microplate assay for cancer cell‐associated cathepsin B by Hulkower, Keren I., Butler, Christopher C., Linebaugh, Bruce E., Klaus, Jeffrey L., Keppler, Daniel, Giranda, Vincent L., Sloane, Bonnie F.

“…Cathepsin B and in particular cell‐surface and secreted cathepsin B has been implicated in the invasive and metastatic phenotype of numerous types of cancer…”
Get full text