Search Results - "Klauke, Karin"

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation by Klauke, Karin, Radulović, Višnja, Broekhuis, Mathilde, Weersing, Ellen, Zwart, Erik, Olthof, Sandra, Ritsema, Martha, Bruggeman, Sophia, Wu, Xudong, Helin, Kristian, Bystrykh, Leonid, de Haan, Gerald

“…The balance between self-renewal and differentiation of adult stem cells is essential for tissue homeostasis. Here we show that in the haematopoietic system…”
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Cellular barcoding tool for clonal analysis in the hematopoietic system by Gerrits, Alice, Dykstra, Brad, Kalmykowa, Olga J., Klauke, Karin, Verovskaya, Evgenia, Broekhuis, Mathilde J.C., de Haan, Gerald, Bystrykh, Leonid V.

“…Clonal analysis is important for many areas of hematopoietic stem cell research, including in vitro cell expansion, gene therapy, and cancer progression and…”
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Physical exercise leads to rapid adaptations in hippocampal vasculature: Temporal dynamics and relationship to cell proliferation and neurogenesis by Van der Borght, Karin, Kóbor-Nyakas, Dóra É., Klauke, Karin, Eggen, Bart J.L., Nyakas, Csaba, Van der Zee, Eddy A., Meerlo, Peter

“…Increased levels of angiogenesis and neurogenesis possibly mediate the beneficial effects of physical activity on hippocampal plasticity. This study was…”
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CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions by Jung, Johannes, Buisman, Sonja C., Weersing, Ellen, Dethmers-Ausema, Albertina, Zwart, Erik, Schepers, Hein, Dekker, Mike R., Lazare, Seka S., Hammerl, Franziska, Skokova, Yulia, Kooistra, Susanne M., Klauke, Karin, Poot, Raymond A., Bystrykh, Leonid V., de Haan, Gerald

“…In this study, we demonstrate that, among all five CBX Polycomb proteins, only CBX7 possesses the ability to control self-renewal of human hematopoietic stem…”
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Polycomb group proteins in hematopoietic stem cell aging and malignancies by Klauke, Karin, de Haan, Gerald

“…Protection of the transcriptional “stemness” network is important to maintain a healthy hematopoietic stem cells (HSCs) compartment during the lifetime of the…”
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Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding by Klauke, Karin, Broekhuis, Mathilde J C, Weersing, Ellen, Dethmers-Ausema, Albertina, Ritsema, Martha, González, Marta Vilà, Zwart, Erik, Bystrykh, Leonid V, de Haan, Gerald

“…Accurate monitoring of tumor dynamics and leukemic stem cell (LSC) heterogeneity is important for the development of personalized cancer therapies. In this…”
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Specific protein homeostatic functions of small heat‐shock proteins increase lifespan by Vos, Michel J., Carra, Serena, Kanon, Bart, Bosveld, Floris, Klauke, Karin, Sibon, Ody C. M., Kampinga, Harm H.

“…Summary During aging, oxidized, misfolded, and aggregated proteins accumulate in cells, while the capacity to deal with protein damage declines severely. To…”
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The Role of Cbx Proteins in Human Benign and Malignant Hematopoiesis by Jung, Johannes, Schepers, Hein, Lazare, Seka, Buisman, Sonja, Weersing, Ellen, Dethmers, Bertien, Klauke, Karin, Bystrykh, Lenja, De Haan, Gerald

“…Introduction: Hematopoietic stem cells (HSCs) need to properly balance self-renewal and differentiation to prevent malignant transformation or HSC exhaustion…”
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The role of CBX proteins in human hematopoiesis by Jung, Johannes, Schepers, Hein, Lazare, Seka, Buisman, Sonja, Weersing, Ellen, Dethmers, Bertien, Klauke, Karin, Bystrykh, Leonid, de Haan, Gerald

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CBX7 regulates self-renewal of human benign HSC and induces terminal differentiation of AML cells by Jung, Johannes, Schepers, Hein, Lazare, Seka, Buisman, Sonja, Weersing, Ellen, Dethmers, Bertien, Zwart, Erik, Klauke, Karin, Poot, Raymond, Bystrykh, Leonid, de Haan, Gerald

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Tracing dynamics and clonal heterogeneity of Cbx7 driven multi-lineage leukemias by cellular barcoding by Klauke, Karin, Broekhuis, Mathilde, Weersing, Ellen, Zwart, Erik, Bystrykh, Leonid, de Haan, Gerald

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Treatment strategies for polycythemia vera: Observations in a Dutch “real‐world” cohort study by van de Ree‐Pellikaan, Claire, de Kreuk, Arne, Schaar, Cees G., Beeker, Aart, Dompeling, Ellen C., Gerrits, Cees J. H., Houten, Anja A., Schipperus, Martin R., Strobbe, Leonie, Posthuma, Eduardus F. M., Klauke, Karin, Westerweel, Peter E.

“…Objectives Assessment of “real‐world” treatment strategies and outcome in Dutch polycythemia vera (PV) patients. Methods Retrospective chart review in 150…”
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Polycomb group proteins in hematopoietic stem cell aging and malignancies : PIH: Hematopoietic Stem Cell Aging by KLAUKE, Karin, DE HAAN, Gerald

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Clonal evolution of leukemic stem cells in a Cbx7-induced leukemia mouse model by Klauke, Karin, Broekhuis, Mathilde, Weersing, Ellen, Ritsema, Martha, Zwart, Erik, van Os, Ronald, Bystrykh, Leonid, de Haan, Gerald

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Hippocampal cell proliferation across the day: Increase by running wheel activity, but no effect of sleep and wakefulness by van der Borght, Karin, Ferrari, Francesca, Klauke, Karin, Roman, Viktor, Havekes, Robbert, Sgoifo, Andrea, van der Zee, Eddy A., Meerlo, Peter

“…The present study investigated whether proliferation of hippocampal progenitors is subject to circadian modulation. Mice were perfused using 3 h intervals…”
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