Search Results - "Klauer, Dominique"

Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-(14C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs by Grunwald, Helge, Hargreaves, Patrick, Gebhardt, Klaus, Klauer, Dominique, Serafyn, Arnaud, Schmitt-Hoffmann, Anne, Schleimer, Michael, Schlotterbeck, Goetz, Wind, Mathias

“…A systematic comparison between two labeling approaches for the investigation of the in vitro metabolic pattern of pharmaceutical drugs was performed by…”
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Investigation of the species-dependent in vitro metabolism of BAL30630 by stable isotope labeling and isotope exchange experiments analyzed by capillary liquid chromatography coupled to mass spectrometry by Wind, Mathias, Grunwald, Helge, Gebhardt, Klaus, Illig, Klaus, Spickermann, Jochen, Nuoffer, Claude, Roussel, Patrick, Klauer, Dominique, Fullhardt, Pascal, Schmitt-Hoffmann, Anne, Schleimer, Michael

“…The in vitro metabolic profile of BAL30630, an antifungal piperazine propanol derivative, which inhibits the 1,3-beta- d-glucansynthase, was investigated by…”
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Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-((14)C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs by Grunwald, Helge, Hargreaves, Patrick, Gebhardt, Klaus, Klauer, Dominique, Serafyn, Arnaud, Schmitt-Hoffmann, Anne, Schleimer, Michael, Schlotterbeck, Goetz, Wind, Mathias

“…A systematic comparison between two labeling approaches for the investigation of the in vitro metabolic pattern of pharmaceutical drugs was performed by…”
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Abstract C233: BAL27862: A unique microtubule-targeted agent with a potential for the treatment of human brain tumors by Schmitt-Hoffmann, Anne, Klauer, Dominique, Gebhardt, Klaus, Fullhardt, Pascal, Brendle, Alain, Hardgreaves, Patrick, Schlaefle, Caroline, Bucher, Christian, Spickermann, Jochen, Defoin, Rosalie, Burger, Karin, Vuong, Van, Bachmann, Felix, Pruschy, Martin, Lane, Heidi

“…Abstract Background: BAL27862 is a synthetic small molecule, potently inducing apoptosis in cancer cells through tubulin depolymerization characterized by a…”
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Investigation of low-abundant in vitro metabolites of stable isotope-labelled BAL4815 by accurate mass capillary-LC-ESI-qTof-MS and MS/MS by Wind, Mathias, Spickermann, Jochen, Schleimer, Michael, Donzelli, Massimiliano, Gebhardt, Klaus, Sturm-Haurany, Rima, Klauer, Dominique, Fullhardt, Pascal, Schmitt-Hoffmann, Anne

“…The metabolic profile of BAL4815, an antifungal azole drug, was determined using in vitro rat hepatocyte incubations and subsequent analysis by capillary…”
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