Search Results - "Klas Karre"

Natural killer cell recognition of missing self by Karre, Klas

“…The idea that NK cells can distinguish aberrant cells by recognizing 'absence of the expected', rather than 'presence of the unexpected' emerged more than 25…”
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NK cell education: not an on-off switch but a tunable rheostat by Brodin, Petter, Kärre, Klas, Höglund, Petter

“…Heterogeneity in the natural killer (NK) cell population is determined by variegated expression of polygenic and polymorphic receptors and distinct phenotypes…”
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A Perfect Mismatch by Karre, Klas

“…Karre comments on a study by Ruggeri et al demonstrating that so-called natural killer (NK) cells can prevent leukemia relapse in leukemic patients, and at the…”
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Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets by Brodin, Petter, Lakshmikanth, Tadepally, Kärre, Klas, Höglund, Petter

“…A major task for the immune system is to secure powerful immune reactions while preserving self-tolerance. This process is particularly challenging for NK…”
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Express Yourself or Die: Peptides, MHC Molecules, and NK Cells by Karre, Klas

“…Natural killer (NK) cells protect the body from infection and mutant cells by assessing cells for self Class I MHC molecules. Research on the role of peptides…”
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The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells by Brodin, Petter, Lakshmikanth, Tadepally, Johansson, Sofia, Kärre, Klas, Höglund, Petter

“…Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I. If self-MHC is down-regulated or absent, lack of…”
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Enrichment of CD56dimKIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients by Ali, Talib Hassan, Pisanti, Simona, Ciaglia, Elena, Mortarini, Roberta, Anichini, Andrea, Garofalo, Cinzia, Tallerico, Rossana, Santinami, Mario, Gulletta, Elio, Ietto, Caterina, Galgani, Mario, Matarese, Giuseppe, Bifulco, Maurizio, Ferrone, Soldano, Colucci, Francesco, Moretta, Alessandro, Kärre, Klas, Carbone, Ennio

“…An important checkpoint in the progression of melanoma is the metastasis to lymph nodes. Here, to investigate the role of lymph node NK cells in disease…”
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Clustering of Major Histocompatibility Complex-Class I Molecules in Healthy and Cancer Colon Cells Revealed from Their Nanomechanical Properties by Moretti, Manola, La Rocca, Rosanna, Perrone Donnorso, Michela, Torre, Bruno, Canale, Claudio, Malerba, Mario, Das, Gobind, Sottile, Rosa, Garofalo, Cinzia, Achour, Adnane, Kärre, Klas, Carbone, Ennio, Di Fabrizio, Enzo

“…The activation of the T cell mediated immune response relies on the fine interaction between the T cell receptor on the immune cell and the antigen-presenting…”
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Expression of CD226 is associated to but not required for NK cell education by Wagner, Arnika K., Kadri, Nadir, Snäll, Johanna, Brodin, Petter, Gilfillan, Susan, Colonna, Marco, Bernhardt, Günter, Höglund, Petter, Kärre, Klas, Chambers, Benedict J.

“…DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its…”
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NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo by Lakshmikanth, Tadepally, Burke, Shannon, Ali, Talib Hassan, Kimpfler, Silvia, Ursini, Francesco, Ruggeri, Loredana, Capanni, Marusca, Umansky, Viktor, Paschen, Annette, Sucker, Antje, Pende, Daniela, Groh, Veronika, Biassoni, Roberto, Höglund, Petter, Kato, Masashi, Shibuya, Kazuko, Schadendorf, Dirk, Anichini, Andrea, Ferrone, Soldano, Velardi, Andrea, Kärre, Klas, Shibuya, Akira, Carbone, Ennio, Colucci, Francesco

“…NK cells use a variety of receptors to detect abnormal cells, including tumors and their metastases. However, in the case of melanoma, it remains to be…”
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Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules by Tallerico, Rossana, Todaro, Matilde, Di Franco, Simone, Maccalli, Cristina, Garofalo, Cinzia, Sottile, Rosa, Palmieri, Camillo, Tirinato, Luca, Pangigadde, Pradeepa N, La Rocca, Rosanna, Mandelboim, Ofer, Stassi, Giorgio, Di Fabrizio, Enzo, Parmiani, Giorgio, Moretta, Alessandro, Dieli, Francesco, Kärre, Klas, Carbone, Ennio

“…Tumor cell populations have been recently proposed to be composed of two compartments: tumor-initiating cells characterized by a slow and asymmetrical growth,…”
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Spatial immunophenotyping of the tumour microenvironment in non–small cell lung cancer by Backman, Max, Strell, Carina, Lindberg, Amanda, Mattsson, Johanna S.M., Elfving, Hedvig, Brunnström, Hans, O'Reilly, Aine, Bosic, Martina, Gulyas, Miklos, Isaksson, Johan, Botling, Johan, Kärre, Klas, Jirström, Karin, Lamberg, Kristina, Pontén, Fredrik, Leandersson, Karin, Mezheyeuski, Artur, Micke, Patrick

“…Immune cells in the tumour microenvironment are associated with prognosis and response to therapy. We aimed to comprehensively characterise the spatial immune…”
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Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2 by Li, Hai, Lakshmikanth, Tadepally, Garofalo, Cinzia, Enge, Martin, Spinnler, Clemens, Anichini, Andrea, Szekely, Laszlo, Kärre, Klas, Carbone, Ennio, Selivanova, Galina

“…Escape of tumor cells from cell-intrinsic barrier mediated by tumor suppressors and cell-extrinsic barrier mediated by the immune system is crucial for…”
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Clever, cleverer, cleverest by Karre, Klas

“…Some strains of mice fail to mount an efficient NK cell response to MCMV infection. With the use of deletion mutants, the in vivo basis for MCMV resistance to…”
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NK‐ and T‐cell subsets in malignant mesothelioma patients: Baseline pattern and changes in the context of anti‐CTLA‐4 therapy by Sottile, Rosa, Tannazi, Milad, Johansson, Maria H., Cristiani, Costanza Maria, Calabró, Luana, Ventura, Valeria, Cutaia, Ornella, Chiarucci, Carla, Covre, Alessia, Garofalo, Cinzia, Pontén, Victor, Tallerico, Rossana, Frumento, Paolo, Micke, Patrick, Maio, Michele, Kärre, Klas, Carbone, Ennio

“…Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid…”
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Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer by Backman, Max, La Fleur, Linnéa, Kurppa, Pinja, Djureinovic, Dijana, Elfving, Hedvig, Brunnström, Hans, Mattsson, Johanna Sofia Margareta, Lindberg, Amanda, Pontén, Victor, Eltahir, Mohamed, Mangsbo, Sara, Gulyas, Miklos, Isaksson, Johan, Jirström, Karin, Kärre, Klas, Leandersson, Karin, Mezheyeuski, Artur, Pontén, Fredrik, Strell, Carina, Lindskog, Cecilia, Botling, Johan, Micke, Patrick

“…Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. The aim of this study was to characterize novel patterns of…”
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MHC Class I–Dependent Shaping of the NK Cell Ly49 Receptor Repertoire Takes Place Early during Maturation in the Bone Marrow by Wickström, Stina L., Wagner, Arnika K., Fuchs, Sina, Elemans, Marjet, Kritikou, Joanna, Mehr, Ramit, Kärre, Klas, Johansson, Maria H., Brauner, Hanna

“…MHC class I (MHC I) expression in the host influences NK cells in a process termed education. The result of this education is reflected in the responsiveness…”
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NK cells control breast cancer and related cancer stem cell hematological spread by Tallerico, Rossana, Conti, Laura, Lanzardo, Stefania, Sottile, Rosa, Garofalo, Cinzia, Wagner, Arnika K, Johansson, Maria H, Cristiani, Costanza Maria, Kärre, Klas, Carbone, Ennio, Cavallo, Federica

“…The growth and recurrence of a number of cancers is driven by a scarce population of cancer stem cells (CSCs), which are resistant to most current therapies…”
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Recognition of β2-Microglobulin-Negative (β2m-) T-Cell Blasts by Natural Killer Cells from Normal but not from β2m-Mice: Nonresponsiveness Controlled by β2m-Bone Marrow in Chimeric Mice by Hoglund, Petter, Ohlen, Claes, Carbone, Ennio, Franksson, Lars, Ljunggren, Hans-Gustaf, Latour, Ann, Koller, Beverly, Karre, Klas

“…The role of major histocompatibility complex (MHC) class I expression in control of the sensitivity of normal cells to natural killer (NK) cells was studied by…”
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The footprint of a killer by Karre, Klas, Schneider, Gunter

“…Natural killer (NK) cells can distinguish normal, healthy cells from aberrant cells in the body. NK cells sometimes carry variants of killer-cell…”
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