Search Results - "Klare, P."

Survival analysis of carboplatin added to an anthracycline/taxane-based neoadjuvant chemotherapy and HRD score as predictor of response—final results from GeparSixto by Loibl, S., Weber, K.E., Timms, K.M., Elkin, E.P., Hahnen, E., Fasching, P.A., Lederer, B., Denkert, C., Schneeweiss, A., Braun, S., Salat, C.T., Rezai, M., Blohmer, J.U., Zahm, D.M., Jackisch, C., Gerber, B., Klare, P., Kümmel, S., Schem, C., Paepke, S., Schmutzler, R., Rhiem, K., Penn, S., Reid, J., Nekljudova, V., Hartman, A.-R., von Minckwitz, G., Untch, M.

“…In the neoadjuvant GeparSixto study, adding carboplatin to taxane- and anthracycline-based chemotherapy improved pathological complete response (pCR) rates in…”
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Neoadjuvant paclitaxel/olaparib in comparison to paclitaxel/carboplatinum in patients with HER2-negative breast cancer and homologous recombination deficiency (GeparOLA study) by Fasching, P.A., Link, T., Hauke, J., Seither, F., Jackisch, C., Klare, P., Schmatloch, S., Hanusch, C., Huober, J., Stefek, A., Seiler, S., Schmitt, W.D., Uleer, C., Doering, G., Rhiem, K., Schneeweiss, A., Engels, K., Denkert, C., Schmutzler, R.K., Hahnen, E., Untch, M., Burchardi, N., Blohmer, J.-U., Loibl, S.

“…The efficacy and toxicity of olaparib as combination therapy in early breast cancer (BC) patients with homologous recombinant deficiency (HRD) [score high…”
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Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation by TOTZECK, Matthias, HENDGEN-COTTA, Ulrike B, GLADWIN, Mark T, SCHRADER, Juergen, KELM, Malte, COSSINS, Andrew R, RASSAF, Tienush, LUEDIKE, Peter, BERENBRINK, Michael, KLARE, Johann P, STEINHOFF, Heinz-Juergen, SEMMLER, Dominik, SHIVA, Sruti, WILLIAMS, Daryl, KIPAR, Anja

“…Hypoxic vasodilation is a physiological response to low oxygen tension that increases blood supply to match metabolic demands. Although this response has been…”
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Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury by Hendgen-Cotta, Ulrike B, Merx, Marc W, Shiva, Sruti, Schmitz, Joel, Becher, Stefanie, Klare, Johann P, Steinhoff, Heinz-Jürgen, Goedecke, Axel, Schrader, Jürgen, Gladwin, Mark T, Kelm, Malte, Rassaf, Tienush

“…The nitrite anion is reduced to nitric oxide (NO{bullet}) as oxygen tension decreases. Whereas this pathway modulates hypoxic NO{bullet} signaling and…”
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Conformational Dynamics of Sensory Rhodopsin II in Nanolipoprotein and Styrene–Maleic Acid Lipid Particles by Mosslehy, Wageiha, Voskoboynikova, Natalia, Colbasevici, Alexandr, Ricke, Adrian, Klose, Daniel, Klare, Johann P., Mulkidjanian, Armen Y., Steinhoff, Heinz‐Jürgen

“…Styrene–maleic acid lipid particles (SMALPs) provide stable water‐soluble nanocontainers for lipid‐encased membrane proteins. Possible effects of the…”
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Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum by Rai, Amrita, Klare, Johann P., Reinke, Patrick Y. A., Englmaier, Felix, Fohrer, Jörg, Fedorov, Roman, Taft, Manuel H., Chizhov, Igor, Curth, Ute, Plettenburg, Oliver, Manstein, Dietmar J.

“…A novel cytoplasmic dye-decolorizing peroxidase from Dictyostelium discoideum was investigated that oxidizes anthraquinone dyes, lignin model compounds, and…”
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Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase by Peulen, Thomas-O, Hengstenberg, Carola S, Biehl, Ralf, Dimura, Mykola, Lorenz, Charlotte, Valeri, Alessandro, Folz, Julian, Hanke, Christian A, Ince, Semra, Vöpel, Tobias, Farago, Bela, Gohlke, Holger, Klare, Johann P, Stadler, Andreas M, Seidel, Claus A M, Herrmann, Christian

“…Guanylate binding proteins (GBPs) are soluble dynamin-like proteins that undergo a conformational transition for GTP-controlled oligomerization and disrupt…”
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Simulation vs. reality: a comparison of in silico distance predictions with DEER and FRET measurements by Klose, Daniel, Klare, Johann P, Grohmann, Dina, Kay, Christopher W M, Werner, Finn, Steinhoff, Heinz-Jürgen

“…Site specific incorporation of molecular probes such as fluorescent- and nitroxide spin-labels into biomolecules, and subsequent analysis by Förster resonance…”
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Development of the signal in sensory rhodopsin and its transfer to the cognate transducer by Engelhard, Martin, Büldt, Georg, Moukhametzianov, Rouslan, Klare, Johann P, Efremov, Rouslan, Baeken, Christian, Göppner, Annika, Labahn, Jörg, Gordeliy, Valentin I

“…The microbial phototaxis receptor sensory rhodopsin II (NpSRII, also named phoborhodopsin) mediates the photophobic response of the haloarchaeon Natronomonas…”
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Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface by Awad, Milena M., Hutton, Melanie L., Quek, Adam J., Klare, William P., Mileto, Steven J., Mackin, Kate, Ly, Diane, Oorschot, Viola, Bosnjak, Marijana, Jenkin, Grant, Conroy, Paul J., West, Nick, Fulcher, Alex, Costin, Adam, Day, Christopher J., Jennings, Michael P., Medcalf, Robert L., Sanderson-Smith, Martina, Cordwell, Stuart J., Law, Ruby H.P., Whisstock, James C., Lyras, Dena

“…The protease plasmin is an important wound healing factor, but it is not clear how it affects gastrointestinal infection–mediated damage, such as that…”
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Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex by Büldt, Georg, Engelhard, Martin, Gordeliy, Valentin I, Labahn, Jörg, Moukhametzianov, Rouslan, Efremov, Rouslan, Granzin, Joachim, Schlesinger, Ramona, Savopol, Tudor, Scheidig, Axel J, Klare, Johann P

“…Microbial rhodopsins, which constitute a family of seven-helix membrane proteins with retinal as a prosthetic group, are distributed throughout the Bacteria,…”
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Topotecan plus carboplatin versus standard therapy with paclitaxel plus carboplatin (PC) or gemcitabine plus carboplatin (GC) or pegylated liposomal doxorubicin plus carboplatin (PLDC): a randomized phase III trial of the NOGGO-AGO-Study Group-AGO Austria and GEICO-ENGOT-GCIG intergroup study (HECTOR) by Sehouli, J., Chekerov, R., Reinthaller, A., Richter, R., Gonzalez-Martin, A., Harter, P., Woopen, H., Petru, E., Hanker, L.C., Keil, E., Wimberger, P., Klare, P., Kurzeder, C., Hilpert, F., Belau, A.K., Zeimet, A., Bover-Barcelo, I., Canzler, U., Mahner, S., Meier, W.

“…The combination of carboplatin and topotecan in platinum-sensitive relapsed ovarian cancer could not improve progression-free survival or overall survival…”
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New Insights on Signal Propagation by Sensory Rhodopsin II/Transducer Complex by Ishchenko, A., Round, E., Borshchevskiy, V., Grudinin, S., Gushchin, I., Klare, J. P., Remeeva, A., Polovinkin, V., Utrobin, P., Balandin, T., Engelhard, M., Büldt, G., Gordeliy, V.

“…The complex of two membrane proteins, sensory rhodopsin II (NpSRII) with its cognate transducer (NpHtrII), mediates negative phototaxis in halobacteria N…”
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Signaling and Adaptation Modulate the Dynamics of the Photosensoric Complex of Natronomonas pharaonis by Orekhov, Philipp S, Klose, Daniel, Mulkidjanian, Armen Y, Shaitan, Konstantin V, Engelhard, Martin, Klare, Johann P, Steinhoff, Heinz-Jürgen

“…Motile bacteria and archaea respond to chemical and physical stimuli seeking optimal conditions for survival. To this end transmembrane chemo- and…”
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Extracellular Loop 4 of the Proline Transporter PutP Controls the Periplasmic Entrance to Ligand Binding Sites by Raba, Michael, Dunkel, Sabrina, Hilger, Daniel, Lipiszko, Kamila, Polyhach, Yevhen, Jeschke, Gunnar, Bracher, Susanne, Klare, Johann P., Quick, Matthias, Jung, Heinrich, Steinhoff, Heinz-Jürgen

“…The Na+/proline symporter (PutP), like several other Na+-coupled symporters, belongs to the so-called LeuT-fold structural family, which features ten…”
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Sorafenib in combination with docetaxel as first-line therapy for HER2-negative metastatic breast cancer: Final results of the randomized, double-blind, placebo-controlled phase II MADONNA study by Mavratzas, A., Baek, S., Gerber, B., Schmidt, M., Moebus, V., Foerster, F., Grischke, E.M., Fasching, P., Strumberg, D., Solomayer, E., Klare, P., Windemuth-Kieselbach, C., Hartmann, S., Schneeweiss, A., Marmé, F.

“…This multicenter, double-blind phase II study assessed the antitumor activity and toxicity profile of docetaxel with the antiangiogenic multikinase inhibitor…”
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Cocaine Directly Impairs Memory Extinction and Alters Brain DNA Methylation Dynamics in Honey Bees by Søvik, Eirik, Berthier, Pauline, Klare, William P, Helliwell, Paul, Buckle, Edwina L S, Plath, Jenny A, Barron, Andrew B, Maleszka, Ryszard

“…Drug addiction is a chronic relapsing behavioral disorder. The high relapse rate has often been attributed to the perseverance of drug-associated memories due…”
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Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations by Rudi, Katharina, Ho, Franz Y, Gilsbach, Bernd K, Pots, Henderikus, Wittinghofer, Alfred, Kortholt, Arjan, Klare, Johann P

“…Ras of complex proteins (Roc) is a Ras-like GTP-binding domain that always occurs in tandem with the C-terminal of Roc (COR) domain and is found in bacteria,…”
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Site-directed spin labeling EPR spectroscopy in protein research by Klare, Johann P

“…Site-directed spin labeling (SDSL) in combination with electron paramagnetic resonance (EPR) spectroscopy has emerged as an efficient tool to elucidate the…”
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Microbial rhodopsins: scaffolds for ion pumps, channels, and sensors by Klare, Johann P, Chizhov, Igor, Engelhard, Martin

“…Microbial rhodopsins have been intensively researched for the last three decades. Since the discovery of bacteriorhodopsin, the scope of microbial rhodopsins…”
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