Search Results - "Klamt, Fabio"

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies by Lopes, Fernanda Martins, Schröder, Rafael, Júnior, Mário Luiz Conte da Frota, Zanotto-Filho, Alfeu, Müller, Carolina Beatriz, Pires, André Simões, Meurer, Rosalva Thereza, Colpo, Gabriela Delevati, Gelain, Daniel Pens, Kapczinski, Flávio, Moreira, José Cláudio Fonseca, Fernandes, Marilda da Cruz, Klamt, Fabio

“…Abstract The molecular mechanisms underlying the cellular lost found in the nigrostriatal pathway during the progression of Parkinson's disease (PD) are not…”
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Master Regulators Connectivity Map: A Transcription Factors-Centered Approach to Drug Repositioning by De Bastiani, Marco A, Pfaffenseller, Bianca, Klamt, Fabio

“…Drug discovery is a very expensive and time-consuming endeavor. Fortunately, recent omics technologies and Systems Biology approaches introduced interesting…”
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Taurine Chloramine, an Oxidant Derived from Neutrophils, Induces Apoptosis in Human B Lymphoma Cells through Mitochondrial Damage by Klamt, Fabio, Shacter, Emily

“…Taurine chloramine (TN-Cl) is one of the most abundant compounds generated by activated neutrophils. In contrast to HOCl, which causes necrosis, TN-Cl is a…”
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Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation by RITTER, Cristiane, ANDRADES, Michael, DAL-PIZZOL, Felipe, FROTA, Mario Luis C, BONATTO, Fernanda, PINHO, Ricardo A, POLYDORO, Manuela, KLAMT, Fabio, PINHEIRO, Cleovaldo T. S, MENNA-BARRETO, Sérgio S, MOREIRA, José Claudio F

“…This study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and…”
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Cholinergic Differentiation of Human Neuroblastoma SH-SY5Y Cell Line and Its Potential Use as an In vitro Model for Alzheimer’s Disease Studies by de Medeiros, Liana M., De Bastiani, Marco A., Rico, Eduardo P., Schonhofen, Patrícia, Pfaffenseller, Bianca, Wollenhaupt-Aguiar, Bianca, Grun, Lucas, Barbé-Tuana, Florência, Zimmer, Eduardo R., Castro, Mauro A. A., Parsons, Richard B., Klamt, Fábio

“…Cholinergic transmission is critical to high-order brain functions such as memory, learning, and attention. Alzheimer’s disease (AD) is characterized by…”
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Damage-associated molecular patterns (DAMPs) related to immunogenic cell death are differentially triggered by clinically relevant chemotherapeutics in lung adenocarcinoma cells by Solari, José Ignácio Gonzalez, Filippi-Chiela, Eduardo, Pilar, Emily Salles, Nunes, Vitória, Gonzalez, Esteban Alberto, Figueiró, Fabrício, Andrade, Cristiano Feijó, Klamt, Fábio

“…Chemotherapeutics can stimulate immune antitumor response by inducing immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns…”
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Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats by Dal-Pizzol, Felipe, Klamt, Fábio, Vianna, Mônica M.R, Schröder, Nadia, Quevedo, João, Benfato, Mara S, Moreira, José C.F, Walz, Roger

“…Oxidative stress has been implicated in a variety of acute and chronic neurologic conditions, including epilepsy. Both the kainic acid and pilocarpine are…”
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Redox Biology of Human Cumulus Cells: Basic Concepts, Impact on Oocyte Quality, and Potential Clinical Use by von Mengden, Lucia, Klamt, Fabio, Smitz, Johan

“…Four decades have passed since the first successful human embryo conceived from a fertilization . Despite all advances, success rates in assisted reproduction…”
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Convalescent Plasma Therapy in Patients With Severe or Life-Threatening COVID-19: A Metadata Analysis by Rabelo-da-Ponte, Francisco Diego, Silvello, Daiane, Scherer, Juliana Nichterwitz, Ayala, Alejandro Raul, Klamt, Fábio

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Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin by Veenstra, Timothy D, Klamt, Fábio, Shacter, Emily, Yu, Li-Rong, Zhang, Yaqin, Levine, Rodney L, Pariser, Ashley, Zhang, Baolin, Zdanov, Stéphanie

“…Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine…”
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High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer’s Disease by Kocinaj, Altin, Chaudhury, Tabassum, Uddin, Mohammed S., Junaid, Rashad R., Ramsden, David B., Hondhamuni, Geshanthi, Klamt, Fábio, Parsons, Linda, Parsons, Richard B.

“…We have previously shown that the expression of nicotinamide N -methyltransferase (NNMT) is significantly increased in the brains of patients who have died of…”
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Metabolic rewiring in melanoma drug-resistant cells by Bristot, Ivi Juliana, Kehl Dias, Camila, Chapola, Henrique, Parsons, Richard B., Klamt, Fábio

“…•Melanoma can shift its metabolic phenotype in response to different forms of treatment that can lead to metastatic outcomes•Expression levels of JARID1B and…”
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A comparative study of COVID-19 transcriptional signatures between clinical samples and preclinical cell models in the search for disease master regulators and drug repositioning candidates by Chapola, Henrique, de Bastiani, Marco Antônio, Duarte, Marcelo Mendes, Freitas, Matheus Becker, Schuster, Jussara Severo, de Vargas, Daiani Machado, Klamt, Fábio

“…•The molecular signature of severe COVID-19 in lung autopsies was stablished.•Six transcription factors were found as Master Regulators for COVID-19 severe…”
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Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas by Pereira, Mery Stefani Leivas, Klamt, Fábio, Thomé, Chairini Cássia, Worm, Paulo Valdeci, de Oliveira, Diogo Losch

“…Metabotropic glutamate receptors (mGluR) are predominantly involved in maintenance of cellular homeostasis of central nervous system. However, evidences have…”
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p53 mutants G245S and R337H associated with the Li-Fraumeni syndrome regulate distinct metabolic pathways by Meneghetti, Bruna Valandro, Wilson, Richard, Dias, Camila Kehl, Cadore, Nathan Araujo, Klamt, Fábio, Zaha, Arnaldo, Ferreira, Henrique Bunselmeyer, Monteiro, Karina Mariante

“…Li-Fraumeni and Li-Fraumeni-like syndromes (LFS/LFL) are hereditary cancer predisposition disorders associated with germline mutations in the TP53 tumor…”
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Glucose and redox metabolism in meiotically blocked in vitro grown mouse antral follicles by Herta, Anamaria-Cristina, von Mengden, Lucia, Akin, Nazli, Billooye, Katy, Coucke, Wim, Cava-Cami, Berta, Klamt, Fábio, Smitz, Johan, Anckaert, Ellen

“…Purpose Glucose and redox metabolism characterization in mouse antral follicles with meiotically blocked oocytes, after in vitro follicle culture (IFC) from…”
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Integrated transcriptomics reveals master regulators of lung adenocarcinoma and novel repositioning of drug candidates by De Bastiani, Marco Antônio, Klamt, Fábio

“…Background Lung adenocarcinoma is the major cause of cancer‐related deaths in the world. Given this, the importance of research on its pathophysiology and…”
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Peripheral biomarkers and illness activity in bipolar disorder by Kapczinski, Flávio, Dal-Pizzol, Felipe, Teixeira, Antonio Lucio, Magalhaes, Pedro V.S, Kauer-Sant’Anna, Márcia, Klamt, Fábio, Moreira, José Claudio F, Augusto de Bittencourt Pasquali, Mateus, Fries, Gabriel Rodrigo, Quevedo, João, Gama, Clarissa Severino, Post, Robert

“…Abstract Recent evidence suggests that peripheral markers related to oxidative stress, inflammation and neurotrophins may be altered during mood episodes in…”
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Genomic and epidemiologic surveillance of SARS-CoV-2 in Southern Brazil and identification of a new Omicron-L452R sublineage by da Silva, Mariana Soares, Gularte, Juliana Schons, Filippi, Micheli, Demoliner, Meriane, Girardi, Viviane, Mosena, Ana Cristina Sbaraini, Pereira, Vyctoria Malayhka de Abreu Góes, Hansen, Alana Witt, Weber, Matheus Nunes, de Almeida, Paula Rodrigues, Fleck, Juliane Deise, Bó, Andrea Gurgel Batista Leite Dal, Jones, Marcus Herbert, Friedrich, Frederico, Filho, Luiz Amorim, Klamt, Fábio, Spilki, Fernando Rosado

“…Recently, SARS-CoV-2 Omicron variant (B.1.1.529) was first identified in Botswana in November 2021. In a short period of time, this highly mutated variant…”
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Cannabinoid-Based Therapies and Brain Development: Potential Harmful Effect of Early Modulation of the Endocannabinoid System by Schonhofen, Patrícia, Bristot, Ivi Juliana, Crippa, José Alexandre, Hallak, Jaime Eduardo Cecílio, Zuardi, Antônio Waldo, Parsons, Richard B., Klamt, Fábio

“…The endocannabinoid retrograde signaling pathway is widely expressed in the central nervous system, where it plays major roles in regulating synaptic…”
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