Search Results - "Klameth, Lukas"
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Small cell lung cancer: model of circulating tumor cell tumorospheres in chemoresistance
Published in Scientific reports (13-07-2017)“…Small cell lung cancer (SCLC) represents 15% of lung cancers and is characterized by early dissemination, development of chemoresistance and a poor prognosis…”
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Effects of salinomycin and niclosamide on small cell lung cancer and small cell lung cancer circulating tumor cell lines
Published in Investigational new drugs (01-08-2020)“…Summary Tumor dissemination and recurrence is attributed to highly resistant cancer stem cells (CSCs) which may constitute a fraction of circulating tumor…”
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Polymer-Ligand-Based ELISA for Robust, High-Throughput, Quantitative Detection of p53 Aggregates
Published in Analytical chemistry (Washington) (20-11-2018)“…A growing number of diseases are being linked to protein misfolding and amyloid formation. Recently, p53 was also shown to associate into amyloid aggregates,…”
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Synergism of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines
Published in Molecules (Basel, Switzerland) (17-02-2014)“…Advanced small cell lung cancer (SCLC) has a dismal prognosis. Modulation of the camptothecin topotecan, approved for second-line therapy, may improve…”
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Receptor tyrosine kinase expression of circulating tumor cells in small cell lung cancer
Published in Oncoscience (31-07-2015)“…Small cell lung cancer (SCLC) has a poor prognosis and is found disseminated at first presentation in the majority of cases. The cell biological mechanisms…”
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Small cell lung cancer: circulating tumor cell lines and expression of mediators of angiogenesis and coagulation
Published in Exploration of targeted anti-tumor therapy (2023)“…Coagulation is frequently activated in cancer patients and has been correlated with an unfavorable prognosis. To evaluate whether a putative release of tissue…”
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The Sulfatase Pathway for Estrogen Formation: Targets for the Treatment and Diagnosis of Hormone-Associated Tumors
Published in Journal of Drug Delivery (01-01-2013)“…The extragonadal synthesis of biological active steroid hormones from their inactive precursors in target tissues is named “intracrinology.” Of particular…”
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Small cell lung cancer: Circulating tumor cells of extended stage patients express a mesenchymal-epithelial transition phenotype
Published in Cell adhesion & migration (03-07-2016)“…Small cell lung cancer (SCLC) is distinguished by aggressive growth, early dissemination and a poor prognosis at advanced stage. The remarkably high count of…”
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Small cell lung cancer: Recruitment of macrophages by circulating tumor cells
Published in Oncoimmunology (03-03-2016)“…Tumor-associated macrophages (TAMs) play an important role in tumor progression, suppression of antitumor immunity and dissemination. Blood monocytes…”
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In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines
Published in Journal of Cancer (01-01-2017)“…Gastric cancer exhibits a poor prognosis and is the third most common cause of cancer death worldwide. Chemotherapy of metastatic gastric cancer is based on…”
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Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy
Published in Cancer letters (28-01-2015)“…Abstract The expression of organic anion transporting polypeptides (OATPs) was elucidated in cell lines from small cell lung cancer (SCLC) and lung carcinoids…”
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Expression of Proteolytic Enzymes by Small Cell Lung Cancer Circulating Tumor Cell Lines
Published in Cancers (19-01-2019)“…Small cell lung cancer (SCLC) is an aggressive type of lung cancer which disseminates vigorously and has a dismal prognosis. Metastasis of SCLC is linked to an…”
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Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes
Published in Food & function (01-03-2015)“…Anthocyans (anthocyanins and their aglycones anthocyanidins) are colorful pigments, naturally occurring in fruits. They exhibit many biological effects and…”
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Effects of chemotherapeutics on expression of cellular pH regulators in small cell lung cancer (SCLC) cell lines
Published in Frontiers in pharmacology (2014)“…Abstract only…”
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