Search Results - "Klaman, L D"

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis by Neel, Benjamin G, Chen, Binbin, Bronson, Roderick T, Klaman, Lori D, Hampton, Thomas G, Wang, Ju-feng, Green, Patricia J, Magnuson, Terry, Douglas, Pamela S, Morgan, James P

“…Atrioventricular and semilunar valve abnormalities are common birth defects, but how cardiac valvulogenesis is directed remains largely unknown. During studies…”
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Detection of the latent form of Epstein-Barr virus DNA in the peripheral blood of healthy individuals by Decker, L L, Klaman, L D, Thorley-Lawson, D A

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Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice by Klaman, Lori D., Boss, Olivier, Peroni, Odile D., Kim, Jason K., Martino, Jennifer L., Zabolotny, Janice M., Moghal, Nadeem, Lubkin, Margaret, Kim, Young-Bum, Sharpe, Arlene H., Stricker-Krongrad, Alain, Shulman, Gerald I., Neel, Benjamin G., Kahn, Barbara B.

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Regulation of Receptor Tyrosine Kinase Signaling by Protein Tyrosine Phosphatase-1B by Haj, Fawaz G., Markova, Boyka, Klaman, Lori D., Bohmer, Frank D., Neel, Benjamin G.

“…Receptor tyrosine kinases (RTKs) are key regulators of cellular homeostasis. Based on in vitro andex vivo studies, protein tyrosine phosphatase-1B (PTP1B) was…”
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Administration of myostatin does not alter fat mass in adult mice by Stolz, L.E, Li, D, Qadri, A, Jalenak, M, Klaman, L.D, Tobin, J.F

“…Myostatin, a member of the TGF-beta superfamily, is produced by skeletal muscle and acts as a negative regulator of muscle mass. It has also been suggested…”
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Essential role for Gab2 in the allergic response by Gu, Haihua, Saito, Kan, Klaman, Lori D, Shen, Junqing, Fleming, Tony, Wang, YongPing, Pratt, Joanne C, Lin, Guosheng, Lim, Bing, Kinet, Jean-Pierre, Neel, Benjamin G

“…Dos/Gab family scaffolding adapters (Dos, Gab1, Gab2) bind several signal relay molecules, including the protein-tyrosine phosphatase Shp-2 and…”
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Prodrug delivery of novel PTP1B inhibitors to enhance insulin signalling by Erbe, D. V., Klaman, L. D., Wilson, D. P., Wan, Z.-K., Kirincich, S. J., Will, S., Xu, X., Kung, L., Wang, S., Tam, S., Lee, J., Tobin, J. F.

“…A growing percentage of the population is resistant to two key hormones – insulin and leptin – as a result of increased obesity, often leading to significant…”
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Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site by Klaman, L D, Thorley-Lawson, D A

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The prototypical Epstein-Barr virus-transformed lymphoblastoid cell line IB4 is an unusual variant containing integrated but no episomal viral DNA by Hurley, E A, Klaman, L D, Agger, S, Lawrence, J B, Thorley-Lawson, D A

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Function of CD48 and its regulation by Epstein-Barr virus by Thorley-Lawson, D A, Ianelli, C, Klaman, L D, Staunton, D, Yokoyama, S

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Overexpression of the LAR (Leukocyte Antigen-Related) Protein-Tyrosine Phosphatase in Muscle Causes Insulin Resistance by Zabolotny, Janice M., Kim, Young-Bum, Peroni, Odile D., Kim, Jason K., Pani, Michael A., Boss, Olivier, Klaman, Lori D., Kamatkar, Shubhangi, Shulman, Gerald I., Kahn, Barbara B., Neel, Benjamin G.

“…Previous reports indicate that the expression and/or activity of the protein-tyrosine phosphatase (PTP) LAR are increased in insulin-responsive tissues of…”
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Is there a unique episome in EBV transformed B cells? by Klaman, L D, Hurley, E A, Thorley-Lawson, D A

“…We have examined the frequency of episome formation in resting B cells 36 hr after infection with Epstein-Barr virus. We have detected an average of 0.65…”
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Deletional mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes by Mainville, CA, Sheehan, KM, Klaman, LD, Giorgetti, CA, Press, JL, Brodeur, PH

“…In addition to the content of germ-line variable gene segments, the organization of V genes has been implicated in the development of the Ab repertoire. We…”
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TT-301 Inhibits Microglial Activation and Improves Outcome after Central Nervous System Injury in Adult Mice by JAMES, Michael L, HAICHEN WANG, CANTILLANA, Viviana, BEILEI LEI, KERNAGIS, Dawn N, DAWSON, Hana N, KLAMAN, Lori D, LASKOWITZ, Daniel T

“…Microglial inhibition may reduce secondary tissue injury and improve functional outcome following acute brain injury. Utilizing clinically relevant murine…”
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Adipose tissue as an active endocrine organ: recent advances by Gimeno, Ruth E, Klaman, Lori D

“…Adipose tissue secretes a variety of factors in a manner dependent upon its metabolic state. These factors are derived from adipocyte or non-adipocyte…”
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An Shp2/SFK/Ras/Erk Signaling Pathway Controls Trophoblast Stem Cell Survival by Yang, Wentian, Klaman, Lori D., Chen, Binbin, Araki, Toshiyuki, Harada, Hisashi, Thomas, Sheila M., George, Elizabeth L., Neel, Benjamin G.

“…Little is known about how growth factors control tissue stem cell survival and proliferation. We analyzed mice with a null mutation of Shp2 (Ptpn11), a key…”
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Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms by Erbe, David V, Wang, Suyue, Zhang, Yan-Ling, Harding, Kimberly, Kung, Leslie, Tam, May, Stolz, Leslie, Xing, Yuzhe, Furey, Sarah, Qadri, Ariful, Klaman, Lori D, Tobin, James F

“…Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2 diabetes. In insulin-resistant rodent models, ertiprotafib and a…”
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Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice by KUSHNER, Jake A, HAJ, Fawaz G, KLAMAN, Lori D, DOW, Matthew A, KAHN, Barbara B, NEEL, Benjamin G, WHITE, Morris F

“…Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice Jake A. Kushner 1 2 , Fawaz G. Haj 3 , Lori…”
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Characterization of the CD48 gene demonstrates a positive element that is specific to Esptein-Barr virus-immortalized B-cell lines and contains an essential NF- Kappa B site by Klaman, L D, Thorley-Lawson, DA

“…Epstein-Barr virus (EBV) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as…”
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Deletional mapping of fifteen mouse V sub(H) gene families reveals a common organization for three Igh haplotypes by Mainville, CA, Sheehan, K M, Klaman, L D, Giorgetti, CA, Press, J L, Brodeur, PH

“…In addition to the content of germ-line variable gene segments, the organization of V genes has been implicated in the development of the Ab repertoire. We…”
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