Search Results - "Klaips, Courtney L."

Pathways of cellular proteostasis in aging and disease by Klaips, Courtney L, Jayaraj, Gopal Gunanathan, Hartl, F Ulrich

“…Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein synthesis, folding, conformational maintenance, and degradation. A…”
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Sis1 potentiates the stress response to protein aggregation and elevated temperature by Klaips, Courtney L., Gropp, Michael H. M., Hipp, Mark S., Hartl, F. Ulrich

“…Cells adapt to conditions that compromise protein conformational stability by activating various stress response pathways, but the mechanisms used in sensing…”
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A Size Threshold Limits Prion Transmission and Establishes Phenotypic Diversity by Derdowski, Aaron, Sindi, Suzanne S., Klaips, Courtney L., DiSalvo, Susanne, Serio, Tricia R.

“…According to the prion hypothesis, atypical phenotypes arise when a prion protein adopts an alternative conformation and persist when that form assembles into…”
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Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing by Klaips, Courtney L, Hochstrasser, Megan L, Langlois, Christine R, Serio, Tricia R

“…The proteostasis network has evolved to support protein folding under normal conditions and to expand this capacity in response to proteotoxic stresses…”
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Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding by Gropp, Michael H.M., Klaips, Courtney L., Hartl, F. Ulrich

“…Manifestation of aggregate pathology in Huntington’s disease is thought to be facilitated by a preferential vulnerability of affected brain cells to…”
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Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2 by Mönkemeyer, Leonie, Klaips, Courtney L., Balchin, David, Körner, Roman, Hartl, F. Ulrich, Bracher, Andreas

“…Eukaryotic elongation factor 2 (eEF2) is an abundant and essential component of the translation machinery. The biogenesis of this 93 kDa multi-domain protein…”
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Defining the limits: Protein aggregation and toxicity in vivo by Holmes, William M, Klaips, Courtney L, Serio, Tricia R

“…Abstract others complementary, to resolve mis-folded proteins when they arise, ranging from refolding through the action of molecular chaperones to elimination…”
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Correction: Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing by Klaips, Courtney L, Hochstrasser, Megan L, Langlois, Christine R, Serio, Tricia R

“…Klaips CL, Hochstrasser ML, Langlois CR, Serio TR. 2014. Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing. eLife…”
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A06 Tuning the stress response pathway to respond to polyq aggregation by Klaips, Courtney L, Gropp, Michael, Hipp, Mark S, Hartl, F Ulrich

“…BackgroundCells can recognize and clear misfolded or aberrant protein species through the upregulation of protein quality control components via the…”
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