Search Results - "Klafki, H.‐W."

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study by Lewczuk, P, Kamrowski-Kruck, H, Peters, O, Heuser, I, Jessen, F, Popp, J, Bürger, K, Hampel, H, Frölich, L, Wolf, S, Prinz, B, Jahn, H, Luckhaus, Ch, Perneczky, R, Hüll, M, Schröder, J, Kessler, H, Pantel, J, Gertz, H-J, Klafki, H-W, Kölsch, H, Reulbach, U, Esselmann, H, Maler, J M, Bibl, M, Kornhuber, J, Wiltfang, J

“…In this report, we present the results of a multicenter study to test analytic and diagnostic performance of soluble forms of amyloid precursor proteins α and…”
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Highly conserved and disease‐specific patterns of carboxyterminally truncated Aβ peptides 1–37/38/39 in addition to 1–40/42 in Alzheimer's disease and in patients with chronic neuroinflammation by Wiltfang, J., Esselmann, H., Bibl, M., Smirnov, A., Otto, M., Paul, S., Schmidt, B., Klafki, H.‐W., Maler, M., Dyrks, T., Bienert, M., Beyermann, M., Rüther, E., Kornhuber, J.

“…Human lumbar CSF patterns of Aβ peptides were analysed by urea‐based β‐amyloid sodium dodecyl sulphate polyacrylamide gel electrophoresis with western…”
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The Carboxyl Termini of β-Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct γ-Secretase Activities by Klafki, H.-W., Abramowski, D., Swoboda, R., Paganetti, P.A., Staufenbiel, M.

“…We have studied the effects of peptide aldehyde protease inhibitors on the secretion of β-amyloid peptide 1-40 (Aβ(1-40)) and Aβ(1-42) by HEK 293 and COS-1…”
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Immune complexes of auto-antibodies against Aβ1-42 peptides patrol cerebrospinal fluid of non-Alzheimer's patients by HENKEL, A. W, DITTRICH, P. S, WILTFANG, J, GROEMER, T. W, LEMKE, E. A, KLINGAUF, J, KLAFKI, H. W, LEWCZUK, P, ESSELMANN, H, SCHWILLE, P, KORNHUBER, J

“…The diagnostic potential of large Aβ-peptide binding particles (LAPs) in the cerebrospinal fluid (CSF) of Alzheimer's dementia (AD) patients and non-AD…”
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Therapeutic approaches to Alzheimer's disease by Klafki, Hans-Wolfgang, Staufenbiel, Matthias, Kornhuber, Johannes, Wiltfang, Jens

“…Alzheimer's disease is an age-related progressive neurodegenerative disorder with an enormous unmet medical need. It is the most common form of dementia…”
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N‐terminal heterogeneity of parenchymal and vascular amyloid‐β deposits in Alzheimer’s disease by Zampar, S., Klafki, H. W., Sritharen, K., Bayer, T. A., Wiltfang, J., Rostagno, A., Ghiso, J., Miles, L. A., Wirths, O.

“…Aims The deposition of amyloid‐β (Aβ) peptides in the form of extracellular plaques in the brain represents one of the classical hallmarks of Alzheimer’s…”
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Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model by Hüttenrauch, M, Brauß, A, Kurdakova, A, Borgers, H, Klinker, F, Liebetanz, D, Salinas-Riester, G, Wiltfang, J, Klafki, H W, Wirths, O

“…The evidence for a protective role of physical activity on the risk and progression of Alzheimer’s disease (AD) has been growing in the last years. Here we…”
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Calpain inhibitor I decreases βA4 secretion from human embryonal kidney cells expressing β-amyloid precursor protein carrying the APP670/671 double mutation by Klafki, Hans-W., Paganetti, Paolo A., Sommer, Bernd, Staufenbiel, Matthias

“…We have investigated the effects of the cell-penetrating cysteine protease inhibitors calpain inhibitor I ( N-acetyl-Leu-Leu-norleucinal) and calpain inhibitor…”
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Synthesis and release of the beta-amyloid precursor protein by bovine chromaffin cells by Bieger, S, Klafki, H W, Unsicker, K

“…Production of the beta-amyloid precursor protein (beta APP) by bovine adrenal chromaffin cells was investigated by polymerase chain reaction (PCR) and by…”
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Amyloid precursor protein truncated at any of the γ-secretase sites is not cleaved to β-amyloid by Paganetti, Paolo A., Lis, Maddalena, Klafki, Hans-Werner, Staufenbiel, Matthias

“…βA4 secretion occurs upon processing of amyloid protein precursor (APP) by β‐secretase (N‐terminus of βA4) and γ‐secretase (C‐terminus). To determine the…”
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Immune complexes of auto-antibodies against A beta 1-42 peptides patrol cerebrospinal fluid of non-Alzheimer's patients by Henkel, A W, Dittrich, P S, Groemer, T W, Lemke, E A, Klingauf, J, Klafki, H W, Lewczuk, P, Esselmann, H, Schwille, P, Kornhuber, J, Wiltfang, J

“…The diagnostic potential of large A beta-peptide binding particles (LAPs) in the cerebrospinal fluid (CSF) of Alzheimer's dementia (AD) patients and non-AD…”
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Complete amino acid sequence determinations demonstrate identity of the urinary Bence Jones protein (BJP-DIA) and the amyloid fibril protein (AL-DIA) in a case of AL-amyloidosis by Klafki, Hans W, Kratzin, Hartmut D, Pick, Albert I, Eckart, Klaus, Karas, Michael, Hilschmann, Norbert

“…The complete primary structures of both the main amyloid fibril protein component (AL-DIA) and the soluble Bence Jones protein (BJP-DIA) obtained from the same…”
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Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43 by Wiltfang, J, Smirnov, A, Schnierstein, B, Kelemen, G, Matthies, U, Klafki, H W, Staufenbiel, M, Hüther, G, Rüther, E, Kornhuber, J

“…Beta-amyloid peptides (A beta peptides) form the main protein component of the amyloid deposits found in the brains of Alzheimer's disease (AD) patients…”
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Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice by Sasmita, Andrew Octavian, Depp, Constanze, Nazarenko, Taisiia, Sun, Ting, Siems, Sophie B., Ong, Erinne Cherisse, Nkeh, Yakum B., Böhler, Carolin, Yu, Xuan, Bues, Bastian, Evangelista, Lisa, Mao, Shuying, Morgado, Barbara, Wu, Zoe, Ruhwedel, Torben, Subramanian, Swati, Börensen, Friederike, Overhoff, Katharina, Spieth, Lena, Berghoff, Stefan A., Sadleir, Katherine Rose, Vassar, Robert, Eggert, Simone, Goebbels, Sandra, Saito, Takashi, Saido, Takaomi, Saher, Gesine, Möbius, Wiebke, Castelo-Branco, Gonçalo, Klafki, Hans-Wolfgang, Wirths, Oliver, Wiltfang, Jens, Jäkel, Sarah, Yan, Riqiang, Nave, Klaus-Armin

“…Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer’s disease (AD). However, transcripts of amyloid precursor protein ( APP ) and amyloidogenic…”
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Reduction of disulfide bonds in an amyloidogenic Bence Jones protein leads to formation of "amyloid-like" fibrils in vitro by Klafki, H W, Pick, A I, Pardowitz, I, Cole, T, Awni, L A, Barnikol, H U, Mayer, F, Kratzin, H D, Hilschmann, N

“…Motivated by the finding that the amino acid sequence of the Bence Jones protein BJP-DIA was identical to that of the main protein component of the amyloid…”
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CSF amyloid-β-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia by Bibl, Mirko, Mollenhauer, Brit, Esselmann, Hermann, Lewczuk, Piotr, Klafki, Hans-Wolfgang, Sparbier, Katrin, Smirnov, Alexandr, Cepek, Lukas, Trenkwalder, Claudia, Rüther, Eckart, Kornhuber, Johannes, Otto, Markus, Wiltfang, Jens

“…As the differential diagnosis of dementias based on established clinical criteria is often difficult, biomarkers for applicable diagnostic testing are…”
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Inhibition of PHF-like tau hyperphosphorylation in SH-SY5Y cells and rat brain slices by K252a by Hübinger, Gabriele, Geis, Silvia, LeCorre, Sylvie, Mühlbacher, Susanne, Gordon, Sandra, Fracasso, R Paul, Hoffman, Fred, Ferrand, Sandrine, Klafki, Hans W, Roder, Hanno M

“…Abnormal hyperphosphorylation of tau is believed to constitute a critical biochemical event in the process of neurofibrillary degeneration of Alzheimer's…”
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Immune complexes of auto-antibodies against A 1-42 peptides patrol cerebrospinal fluid of non-Alzheimer's patients by Henkel, A W, Dittrich, P S, Groemer, T W, Lemke, E A, Klingauf, J, Klafki, H W, Lewczuk, P, Esselmann, H, Schwille, P, Kornhuber, J, Wiltfang, J

“…The diagnostic potential of large A beta-peptide binding particles (LAPs) in the cerebrospinal fluid (CSF) of Alzheimer's dementia (AD) patients and non-AD…”
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Distinct fractional Aβ release patterns in human mononuclear phagocytes by Maler, Juan Manuel, Spitzer, Philipp, Klafki, Hans-Wolfgang, Esselmann, Hermann, Lewczuk, Piotr, Kornhuber, Johannes, Herrmann, Martin, Wiltfang, Jens

“…Abstract The presence of cells of the mononuclear phagocyte lineage surrounding neuritic and vascular β-amyloid (Aβ) plaques is a hallmark of Alzheimer's…”
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CSF amyloid-β 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction by Bibl, Mirko, Lewczuk, Piotr, Esselmann, Hermann, Mollenhauer, Brit, Klafki, Hans-Wolfgang, Welge, Volker, Wolf, Stefanie, Trenkwalder, Claudia, Otto, Markus, Kornhuber, Johannes, Wiltfang, Jens

“…Cerebrospinal fluid (CSF) Aβ1‐38, Aβ1‐40, and Aβ1‐42 were comparatively analyzed by amyloid‐beta SDS‐PAGE with Western immunoblot (Aβ‐SDS‐PAGE/immunoblot),…”
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