Search Results - "Klaeger, Susan"

Tracking cancer drugs in living cells by thermal profiling of the proteome by Savitski, Mikhail M., Reinhard, Friedrich B. M., Franken, Holger, Werner, Thilo, Savitski, Maria Fälth, Eberhard, Dirk, Molina, Daniel Martinez, Jafari, Rozbeh, Dovega, Rebecca Bakszt, Klaeger, Susan, Kuster, Bernhard, Nordlund, Pär, Bantscheff, Marcus, Drewes, Gerard

“…The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of…”
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Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics by Wilhelm, Mathias, Zolg, Daniel P., Graber, Michael, Gessulat, Siegfried, Schmidt, Tobias, Schnatbaum, Karsten, Schwencke-Westphal, Celina, Seifert, Philipp, de Andrade Krätzig, Niklas, Zerweck, Johannes, Knaute, Tobias, Bräunlein, Eva, Samaras, Patroklos, Lautenbacher, Ludwig, Klaeger, Susan, Wenschuh, Holger, Rad, Roland, Delanghe, Bernard, Huhmer, Andreas, Carr, Steven A., Clauser, Karl R., Krackhardt, Angela M., Reimer, Ulf, Kuster, Bernhard

“…Characterizing the human leukocyte antigen (HLA) bound ligandome by mass spectrometry (MS) holds great promise for developing vaccines and drugs for…”
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Plant Cytokinesis Is Orchestrated by the Sequential Action of the TRAPPII and Exocyst Tethering Complexes by Rybak, Katarzyna, Steiner, Alexander, Synek, Lukas, Klaeger, Susan, Kulich, Ivan, Facher, Eva, Wanner, Gerhard, Kuster, Bernhard, Zarsky, Viktor, Persson, Staffan, Assaad, Farhah F.

“…Plant cytokinesis is initiated in a transient membrane compartment, the cell plate, and completed by a process of maturation during which the cell plate…”
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Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors by Klaeger, Susan, Gohlke, Bjoern, Perrin, Jessica, Gupta, Vipul, Heinzlmeir, Stephanie, Helm, Dominic, Qiao, Huichao, Bergamini, Giovanna, Handa, Hiroshi, Savitski, Mikhail M, Bantscheff, Marcus, Médard, Guillaume, Preissner, Robert, Kuster, Bernhard

“…Many protein kinases are valid drug targets in oncology because they are key components of signal transduction pathways. The number of clinical kinase…”
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Interactions between Transport Protein Particle (TRAPP) complexes and Rab GTPases in Arabidopsis by Kalde, Monika, Elliott, Liam, Ravikumar, Raksha, Rybak, Katarzyna, Altmann, Melina, Klaeger, Susan, Wiese, Christian, Abele, Miriam, Al, Benjamin, Kalbfuß, Nils, Qi, Xingyun, Steiner, Alexander, Meng, Chen, Zheng, Huanquan, Kuster, Bernhard, Falter‐Braun, Pascal, Ludwig, Christina, Moore, Ian, Assaad, Farhah F.

“…Summary Transport Protein Particle II (TRAPPII) is essential for exocytosis, endocytosis, protein sorting and cytokinesis. In spite of a considerable…”
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Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues by Abelin, Jennifer G., Bergstrom, Erik J., Rivera, Keith D., Taylor, Hannah B., Klaeger, Susan, Xu, Charles, Verzani, Eva K., Jackson White, C., Woldemichael, Hilina B., Virshup, Maya, Olive, Meagan E., Maynard, Myranda, Vartany, Stephanie A., Allen, Joseph D., Phulphagar, Kshiti, Harry Kane, M., Rachimi, Suzanna, Mani, D. R., Gillette, Michael A., Satpathy, Shankha, Clauser, Karl R., Udeshi, Namrata D., Carr, Steven A.

“…Serial multi-omic analysis of proteome, phosphoproteome, and acetylome provides insights into changes in protein expression, cell signaling, cross-talk and…”
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Pharmacoproteomic characterisation of human colon and rectal cancer by Frejno, Martin, Zenezini Chiozzi, Riccardo, Wilhelm, Mathias, Koch, Heiner, Zheng, Runsheng, Klaeger, Susan, Ruprecht, Benjamin, Meng, Chen, Kramer, Karl, Jarzab, Anna, Heinzlmeir, Stephanie, Johnstone, Elaine, Domingo, Enric, Kerr, David, Jesinghaus, Moritz, Slotta‐Huspenina, Julia, Weichert, Wilko, Knapp, Stefan, Feller, Stephan M, Kuster, Bernhard

“…Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome‐guided pre‐clinical drug…”
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Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells by Scharow, Andrej, Raab, Monika, Saxena, Krishna, Sreeramulu, Sridhar, Kudlinzki, Denis, Gande, Santosh, Dötsch, Christina, Kurunci-Csacsko, Elisabeth, Klaeger, Susan, Kuster, Bernhard, Schwalbe, Harald, Strebhardt, Klaus, Berg, Thorsten

“…Polo-like kinase 1 (Plk1) is a central regulator of mitosis and has been validated as a target for antitumor therapy. The polo-box domain (PBD) of Plk1…”
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Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs by Heinzlmeir, Stephanie, Kudlinzki, Denis, Sreeramulu, Sridhar, Klaeger, Susan, Gande, Santosh Lakshmi, Linhard, Verena, Wilhelm, Mathias, Qiao, Huichao, Helm, Dominic, Ruprecht, Benjamin, Saxena, Krishna, Médard, Guillaume, Schwalbe, Harald, Kuster, Bernhard

“…The receptor tyrosine kinase EPHA2 (Ephrin type-A receptor 2) plays important roles in oncogenesis, metastasis, and treatment resistance, yet therapeutic…”
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Cell cycle‐regulated PLEIADE/AtMAP65‐3 links membrane and microtubule dynamics during plant cytokinesis by Steiner, Alexander, Rybak, Katarzyna, Altmann, Melina, McFarlane, Heather E., Klaeger, Susan, Nguyen, Ngoc, Facher, Eva, Ivakov, Alexander, Wanner, Gerhard, Kuster, Bernhard, Persson, Staffan, Braun, Pascal, Hauser, Marie‐Theres, Assaad, Farhah F.

“…Summary Cytokinesis, the partitioning of the cytoplasm following nuclear division, requires extensive coordination between cell cycle cues, membrane…”
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Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies by Yin, Shanye, Klaeger, Susan, Chea, Vipheaviny A, Carulli, Isabel P, Rachimi, Suzanna, Black, Katharine E, Filbin, Michael, Hariri, Lida P, Knipe, Rachel S, Padera, Robert F, Stevens, Jonathan D, Lane, William J, Carr, Steven A, Wu, Catherine J, Kim, Edy Yong, Keskin, Derin B

“…Severe respiratory illness is the most prominent manifestation of patients infected with SARS-CoV-2, and yet the molecular mechanisms underlying severe lung…”
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Author Correction: Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics by Wilhelm, Mathias, Zolg, Daniel P., Graber, Michael, Gessulat, Siegfried, Schmidt, Tobias, Schnatbaum, Karsten, Schwencke-Westphal, Celina, Seifert, Philipp, de Andrade Krätzig, Niklas, Zerweck, Johannes, Knaute, Tobias, Bräunlein, Eva, Samaras, Patroklos, Lautenbacher, Ludwig, Klaeger, Susan, Wenschuh, Holger, Rad, Roland, Delanghe, Bernard, Huhmer, Andreas, Carr, Steven A., Clauser, Karl R., Krackhardt, Angela M., Reimer, Ulf, Kuster, Bernhard

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145 Proteogenomic approaches for exploring the dark immunopeptidome by Leskoske, Kristin, Gurung, Hem, Magalhaes, Ana, Vaidya, Samir, Le, Daniel, Xu, Hang, Liang, Yuxin, Klaeger, Susan

“…BackgroundComprehensive coverage of the class I human leukocyte antigen (HLA-I) immunopeptidome can help inform the development of cancer immunotherapies…”
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1408 Non-canonical peptide sources broaden the landscape of targetable antigens in pancreatic cancer by Ely, Zackery A, Kulstad, Zachary J, Abelin, Jennifer G, Verzani, Eva K, Addepalli, Sudarsana, Clauser, Karl, Kapner, Kevin S, Hennessey, Connor J, Agus, Miles, Klaeger, Susan, Jaeger, Alex M, Su, Jennifer, Greenberg, Philip D, Aguirre, Andrew J, Carr, Steven, Jacks, Tyler, Freed-Pastor, William

“…BackgroundAberrant translation of the non-coding genome in cancer can generate novel peptides capable of presentation by major histocompatibility complex class…”
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HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses by Weingarten-Gabbay, Shira, Pearlman, Leah R., Chen, Da-Yuan, Klaeger, Susan, Taylor, Hannah B., Welch, Nicole L., Keskin, Derin B., Carr, Steven A., Abelin, Jennifer G., Saeed, Mohsan, Sabeti, Pardis C.

“…Immunopeptidome profiling of infected cells is a powerful technique for detecting viral peptides that are naturally processed and loaded onto class I human…”
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The peptide woods are lovely, dark and deep: Hunting for novel cancer antigens by Oreper, Daniel, Klaeger, Susan, Jhunjhunwala, Suchit, Delamarre, Lélia

“…Harnessing the patient’s immune system to control a tumor is a proven avenue for cancer therapy. T cell therapies as well as therapeutic vaccines, which target…”
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Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma by Oliveira, Giacomo, Stromhaug, Kari, Klaeger, Susan, Kula, Tomasz, Frederick, Dennie T., Le, Phuong M., Forman, Juliet, Huang, Teddy, Li, Shuqiang, Zhang, Wandi, Xu, Qikai, Cieri, Nicoletta, Clauser, Karl R., Shukla, Sachet A., Neuberg, Donna, Justesen, Sune, MacBeath, Gavin, Carr, Steven A., Fritsch, Edward F., Hacohen, Nir, Sade-Feldman, Moshe, Livak, Kenneth J., Boland, Genevieve M., Ott, Patrick A., Keskin, Derin B., Wu, Catherine J.

“…Interactions between T cell receptors (TCRs) and their cognate tumour antigens are central to antitumour immune responses 1 – 3 ; however, the relationship…”
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DMSO enhances electrospray response, boosting sensitivity of proteomic experiments by Hahne, Hannes, Pachl, Fiona, Ruprecht, Benjamin, Maier, Stefan K, Klaeger, Susan, Helm, Dominic, Médard, Guillaume, Wilm, Matthias, Lemeer, Simone, Kuster, Bernhard

“…The addition of a low percentage of DMSO into liquid chromatography solvents strongly enhances peptide electrospray ionization, substantially improving…”
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A large peptidome dataset improves HLA class I epitope prediction across most of the human population by Sarkizova, Siranush, Klaeger, Susan, Le, Phuong M., Li, Letitia W., Oliveira, Giacomo, Keshishian, Hasmik, Hartigan, Christina R., Zhang, Wandi, Braun, David A., Ligon, Keith L., Bachireddy, Pavan, Zervantonakis, Ioannis K., Rosenbluth, Jennifer M., Ouspenskaia, Tamara, Law, Travis, Justesen, Sune, Stevens, Jonathan, Lane, William J., Eisenhaure, Thomas, Lan Zhang, Guang, Clauser, Karl R., Hacohen, Nir, Carr, Steven A., Wu, Catherine J., Keskin, Derin B.

“…Prediction of HLA epitopes is important for the development of cancer immunotherapies and vaccines. However, current prediction algorithms have limited…”
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Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer by Ouspenskaia, Tamara, Law, Travis, Clauser, Karl R., Klaeger, Susan, Sarkizova, Siranush, Aguet, François, Li, Bo, Christian, Elena, Knisbacher, Binyamin A., Le, Phuong M., Hartigan, Christina R., Keshishian, Hasmik, Apffel, Annie, Oliveira, Giacomo, Zhang, Wandi, Chen, Sarah, Chow, Yuen Ting, Ji, Zhe, Jungreis, Irwin, Shukla, Sachet A., Justesen, Sune, Bachireddy, Pavan, Kellis, Manolis, Getz, Gad, Hacohen, Nir, Keskin, Derin B., Carr, Steven A., Wu, Catherine J., Regev, Aviv

“…Tumor-associated epitopes presented on MHC-I that can activate the immune system against cancer cells are typically identified from annotated protein-coding…”
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