Search Results - "Klabunde, T"

Chemogenomic approaches to drug discovery: similar receptors bind similar ligands by Klabunde, T

“…Within recent years, a paradigm shift from traditional receptor‐specific studies to a cross‐receptor view has taken place within pharmaceutical research to…”
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Drug Design Strategies for Targeting G-Protein-Coupled Receptors by Klabunde, Thomas, Hessler, Gerhard

“…G‐protein‐coupled receptors (GPCRs) form a large protein family that plays an important role in many physiological and pathophysiological processes. Since the…”
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A Population Dose–Response Model for Inhaled Technosphere Insulin Administered to Healthy Subjects by Rüppel, D, Dahmen, R, Boss, A, Jäger, R, Grant, M, Baughman, R, Klabunde, T

“…Technosphere insulin (TI), an inhaled insulin with a fast onset of action, provides a novel option for the control of prandial glucose. A euglycemic glucose…”
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Computational approaches towards the rational design of drug-like compound libraries by Matter, H, Baringhaus, K H, Naumann, T, Klabunde, T, Pirard, B

“…During the practice of combinatorial chemistry, it has been realized that molecular diversity is not the only essential feature in a synthetically feasible…”
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Structure-based Drug Discovery Using GPCR Homology Modeling:  Successful Virtual Screening for Antagonists of the Alpha1A Adrenergic Receptor by Evers, Andreas, Klabunde, Thomas

“…In this paper, we describe homology modeling of the alpha1A receptor based on the X-ray structure of bovine rhodopsin. The protein model has been generated by…”
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Virtual Screening of Biogenic Amine-Binding G-Protein Coupled Receptors:  Comparative Evaluation of Protein- and Ligand-Based Virtual Screening Protocols by Evers, Andreas, Hessler, Gerhard, Matter, Hans, Klabunde, Thomas

“…In this paper, we compare protein- and ligand-based virtual screening techniques for identifying the ligands of four biogenic amine-binding G-protein coupled…”
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GPCR Antitarget Modeling: Pharmacophore Models for Biogenic Amine Binding GPCRs to Avoid GPCR-Mediated Side Effects by Klabunde, Thomas, Evers, Andreas

“…G protein-coupled receptors (GPCRs) form a large protein family that plays an important role in many physiological and pathophysiological processes. However,…”
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Chemogenomic approaches to rational drug design. Commentary by KLABUNDE, T, ROGNAN, D

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Identification of Nonpeptidic Urotensin II Receptor Antagonists by Virtual Screening Based on a Pharmacophore Model Derived from Structure−Activity Relationships and Nuclear Magnetic Resonance Studies on Urotensin II by Flohr, Stefanie, Kurz, Michael, Kostenis, Evi, Brkovich, Alexandre, Fournier, Alain, Klabunde, Thomas

“…The vasoactive cyclic 11-amino acid peptide urotensin II (U-II) has recently been discovered as the endogenous ligand of the orphan G-protein-coupled receptor…”
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A Population Dose-Response Model for Inhaled Technosphere Insulin Administered to Healthy Subjects: Dose-Response Model for Inhaled Technosphere Insulin by Rüppel, D, Dahmen, R, Boss, A, Jäger, R, Grant, M, Baughman, R, Klabunde, T

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Rational design of potent human transthyretin amyloid disease inhibitors by Sacchettini, James C, Klabunde, Thomas, Petrassi, H. Michael, Oza, Vibha B, Raman, Prakash, Kelly, Jeffery W

“…The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble…”
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Chemogenomics approaches to G-protein coupled receptor lead finding by Klabunde, T, Jäger, R

“…G-protein coupled receptors (GPCRs) are promising targets for the discovery of novel drugs. In order to identify novel chemical series, high-throughput…”
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Mechanism of Fe(III) – Zn(II) Purple Acid Phosphatase Based on Crystal Structures by Klabunde, Thomas, Sträter, Norbert, Fröhlich, Roland, Witzel, Herbert, Krebs, Bernt

“…Purple acid phosphatase is a widely distributed non-specific phosphomonoesterase. X-ray structures of the dimeric 111-kDa Fe(III)-Zn(II) kidney bean purple…”
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Crystal Structure of a Purple Acid Phosphatase Containing a Dinuclear Fe(III)-Zn(II) Active Site by Sträter, Norbert, Klabunde, Thomas, Tucker, Paul, Witzel, Herbert, Krebs, Bernt

“…Kidney bean purple acid phosphatase (KBPAP) is an Fe(III)-Zn(II) metalloenzyme resembling the mammalian Fe(III)-Fe(II) purple acid phosphatases. The structure…”
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X-ray absorption studies of the purple acid phosphatase from red kidney beans (native enzyme, metal exchanged form) by Ahlers, F., Zippel, F., Klabunde, T., Krebs, B., Löcke, R., Witzel, H., Nolting, H.-F.

“…Purple acid phosphatase from red kidney beans (KBP) catalyzes the hydrolysis of activated phosphoric acid monoesters and contains a heterodinuclear…”
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Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes by Klabunde, Thomas, Wendt, K. Ulrich, Kadereit, Dieter, Brachvogel, Volker, Burger, Hans-Jörg, Herling, Andreas W, Oikonomakos, Nikos G, Kosmopoulou, Magda N, Schmoll, Dieter, Sarubbi, Edoardo, von Roedern, Erich, Schönafinger, Karl, Defossa, Elisabeth

“…Using a focused screening approach, acyl ureas have been discovered as a new class of inhibitors of human liver glycogen phosphorylase (hlGPa). The X-ray…”
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Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi by Eicken, Christoph, Sharma, Vivek, Klabunde, Thomas, Lawrenz, Matthew B, Hardham, John M, Norris, Steven J, Sacchettini, James C

“…VlsE is an outer surface lipoprotein of Borrelia burgdorferi that undergoes antigenic variation through an elaborate gene conversion mechanism and is thought…”
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Inhibiting Transthyretin Conformational Changes that Lead to Amyloid Fibril Formation by Peterson, Scott A., Klabunde, Thomas, Lashuel, Hilal A., Purkey, Hans, Sacchettini, James C., Kelly, Jeffrey W.

“…Insoluble protein fibrils resulting from the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human…”
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Crystal structure of a plant catechol oxidase containing a dicopper center by Sacchettini, James C, Krebs, Bernt, Klabunde, Thomas, Eicken, Christoph

“…Catechol oxidases are ubiquitous plant enzymes containing a dinuclear copper center. In the wound-response mechanism of the plant they catalyze the oxidation…”
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Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines by Sacchettini, James C, Ronning, Donald R, Klabunde, Thomas, Besra, Gurdyal S, Vissa, Varalakshmi D, Belisle, John T

“…The antigen 85 (ag85) complex, composed of three proteins (ag85A, B and C), is a major protein component of the Mycobacterium tuberculosis cell wall. Each…”
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