Search Results - "Klaassen, Steven D."

Comparative physiology and efficacy of atropine and scopolamine in sarin nerve agent poisoning by Cornelissen, Alex S., Klaassen, Steven D., van Groningen, Tomas, Bohnert, Sara, Joosen, Marloes J.A.

“…Anticholinergic treatment is key for effective medical treatment of nerve agent exposure. Atropine is included at a 2 mg intramuscular dose in so-called…”
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Synergistic polytherapy for the broad-spectrum treatment of chemically-induced seizures in rats by Cornelissen, Alex S., van den Berg, Roland M., Klaassen, Steven D., de Koning, Jelle C., Langenberg, Jan P., de Lange, Elizabeth C.M., Joosen, Marloes J.A.

“…Chemically-induced seizures, as a result of exposure to a neurotoxic compound, present a serious health concern. Compounds can elicit seizure activity through…”
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Pharmacokinetics of Three Oximes in a Guinea Pig Model and Efficacy of Combined Oxime Therapy by Bohnert, Sara, van den Berg, Roland M., Mikler, John, Klaassen, Steven D., Joosen, Marloes J.A.

“…•PK of three oximes was determined in healthy and sarin-challenged guinea pigs.•Combination of oxime therapy does not result in adverse events.•PK of each…”
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Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model by Kentrop, Jiska, Savransky, Vladimir, Klaassen, Steven D., van Groningen, Tomas, Bohnert, Sara, Cornelissen, Alex S., Cochrane, Laura, Barry, John, Joosen, Marloes J.A.

“…Nerve agent exposure is generally treated by an antidote formulation composed of a muscarinic antagonist, atropine sulfate (ATR), and a reactivator of…”
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Increasing nerve agent treatment efficacy by P-glycoprotein inhibition by Joosen, Marloes J.A., Vester, Stefanie M., Hamelink, Jouk, Klaassen, Steven D., van den Berg, Roland M.

“…One of the shortcomings of current treatment of nerve agent poisoning is that not all drugs effectively penetrate the blood-brain barrier (BBB), whereas most…”
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Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase by de Koning, Martijn C, Joosen, Marloes J. A, Worek, Franz, Nachon, Florian, van Grol, Marco, Klaassen, Steven D, Alkema, Duurt P. W, Wille, Timo, de Bruijn, Hans M

“…Recently, a new class of reactivators of chemical warfare agent inhibited acetylcholinesterase (AChE) with promising in vitro potential was developed by the…”
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Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs by Joosen, Marloes J.A., Klaassen, Steven D., Verheij, Elwin, van Groningen, Tomas, Cornelissen, Alex S., Skiadopoulos, Mario H., Cochrane, Laura, Shearer, Jeff D.

“…The efficacy and pharmacokinetics of the aqueous co-formulation contents of the Trobigard™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated…”
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Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar by Meerhoff, Gideon F., Vester, Stefanie M., Hesseling, Peter, Klaassen, Steven D., Cornelissen, Alex S., Lucassen, Paul J., Joosen, Marloes J.A.

“…•Addition of tariquidar to HI-6 and atropine mitigated soman induced seizures.•In combination with diazepam, tariquidar further enhanced efficacy.•A…”
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