White matter hyperintensity shape is associated with long‐term dementia risk

INTRODUCTION We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long‐term dementia risk in community‐dwelling older adults. METHODS Three thousand seventy‐seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibilit...

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Published in:	Alzheimer's & dementia Vol. 19; no. 12; pp. 5632 - 5641
Main Authors:	Keller, Jasmin Annica, Sigurdsson, Sigurdur, Klaassen, Kelly, Hirschler, Lydiane, Buchem, Mark A., Launer, Lenore J., Osch, Matthias J. P., Gudnason, Vilmundur, de Bresser, Jeroen
Format:	Journal Article
Language:	English
Published:	United States 01-12-2023
Subjects:	Aged Aged, 80 and over Brain - diagnostic imaging Brain - pathology cerebral small vessel disease cognitive decline dementia Dementia - diagnostic imaging Dementia - epidemiology Dementia - pathology Humans Magnetic Resonance Imaging Prognosis Proportional Hazards Models White Matter - diagnostic imaging White Matter - pathology white matter hyperintensities cerebral small vessel disease dementia magnetic resonance imaging cognitive decline white matter hyperintensities
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Summary:	INTRODUCTION We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long‐term dementia risk in community‐dwelling older adults. METHODS Three thousand seventy‐seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)‐Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow‐up: 9.9 ± 2.6 years). RESULTS More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long‐term dementia risk. DISCUSSION WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community‐dwelling older adults.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1552-5260 1552-5279 1552-5279
DOI:	10.1002/alz.13345