Search Results - "Kløverpris, Henrik N"

Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point by Ndhlovu, Zaza M., Kamya, Philomena, Mewalal, Nikoshia, Kløverpris, Henrik N., Nkosi, Thandeka, Pretorius, Karyn, Laher, Faatima, Ogunshola, Funsho, Chopera, Denis, Shekhar, Karthik, Ghebremichael, Musie, Ismail, Nasreen, Moodley, Amber, Malik, Amna, Leslie, Alasdair, Goulder, Philip J.R., Buus, Søren, Chakraborty, Arup, Dong, Krista, Ndung’u, Thumbi, Walker, Bruce D.

“…CD8+ T cells contribute to the control of HIV, but it is not clear whether initial immune responses modulate the viral set point. We screened high-risk…”
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Type 3 ILCs in Lung Disease by Ardain, Amanda, Porterfield, James Zachary, Kløverpris, Henrik N, Leslie, Alasdair

“…The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate…”
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Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung by Ogongo, Paul, Tezera, Liku B, Ardain, Amanda, Nhamoyebonde, Shepherd, Ramsuran, Duran, Singh, Alveera, Ng'oepe, Abigail, Karim, Farina, Naidoo, Taryn, Khan, Khadija, Dullabh, Kaylesh J, Fehlings, Michael, Lee, Boon Heng, Nardin, Alessandra, Lindestam Arlehamn, Cecilia S, Sette, Alessandro, Behar, Samuel M, Steyn, Adrie Jc, Madansein, Rajhmun, Kløverpris, Henrik N, Elkington, Paul T, Leslie, Alasdair

“…T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood…”
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Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency by Simoni, Yannick, Fehlings, Michael, Kløverpris, Henrik N., McGovern, Naomi, Koo, Si-Lin, Loh, Chiew Yee, Lim, Shawn, Kurioka, Ayako, Fergusson, Joannah R., Tang, Choong-Leong, Kam, Ming Hian, Dennis, Koh, Lim, Tony Kiat Hon, Fui, Alexander Chung Yaw, Hoong, Chan Weng, Chan, Jerry Kok Yen, Curotto de Lafaille, Maria, Narayanan, Sriram, Baig, Sonia, Shabeer, Muhammad, Toh, Sue-Anne Ee Shiow, Tan, Henry Kun Kiaang, Anicete, Rosslyn, Tan, Eng-Huat, Takano, Angela, Klenerman, Paul, Leslie, Alasdair, Tan, Daniel S.W., Tan, Iain Beehuat, Ginhoux, Florent, Newell, Evan W.

“…Animal models have highlighted the importance of innate lymphoid cells (ILCs) in multiple immune responses. However, technical limitations have hampered…”
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Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation by Kummerlowe, Conner, Mwakamui, Simutanyi, Hughes, Travis K, Mulugeta, Nolawit, Mudenda, Victor, Besa, Ellen, Zyambo, Kanekwa, Shay, Jessica E S, Fleming, Ira, Vukovic, Marko, Doran, Ben A, Aicher, Toby P, Wadsworth, 2nd, Marc H, Bramante, Juliet Tongue, Uchida, Amiko M, Fardoos, Rabiah, Asowata, Osaretin E, Herbert, Nicholas, Yilmaz, Ömer H, Kløverpris, Henrik N, Garber, John J, Ordovas-Montañes, José, Gartner, Zev J, Wallach, Thomas, Shalek, Alex K, Kelly, Paul

“…Environmental enteropathy (EE) is a subclinical condition of the small intestine that is highly prevalent in low- and middle-income countries. It is thought to…”
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HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control by Fardoos, Rabiah, Nyquist, Sarah K., Asowata, Osaretin E., Kazer, Samuel W., Singh, Alveera, Ngoepe, Abigail, Giandhari, Jennifer, Mthabela, Ntombifuthi, Ramjit, Dirhona, Singh, Samita, Karim, Farina, Buus, Søren, Anderson, Frank, Porterfield, J. Zachary, Sibiya, Andile L., Bipath, Rishan, Moodley, Kumeshan, Kuhn, Warren, Berger, Bonnie, Nguyen, Son, de Oliveira, Tulio, Ndung’u, Thumbi, Goulder, Philip, Shalek, Alex K., Leslie, Alasdair, Kløverpris, Henrik N.

“…Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by…”
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Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life by Attaf, Meriem, Roider, Julia, Malik, Amna, Rius Rafael, Cristina, Dolton, Garry, Predergast, Andrew J, Leslie, Alasdair, Ndung'u, Thumbi, Kløverpris, Henrik N, Sewell, Andrew K, Goulder, Philip J

“…Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response…”
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Major TCR Repertoire Perturbation by Immunodominant HLA-B44:03-Restricted CMV-Specific T Cells by Attaf, Meriem, Malik, Amna, Severinsen, Mai C., Roider, Julia, Ogongo, Paul, Buus, Søren, Ndung'u, Thumbi, Leslie, Alasdair, Kløverpris, Henrik N., Matthews, Philippa C., Sewell, Andrew K., Goulder, Philip

“…Lack of disease during chronic human cytomegalovirus (CMV) infection depends on the maintenance of a high-frequency CMV-specific T cell response. The…”
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Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy by Singh, Alveera, Kazer, Samuel W., Roider, Julia, Krista, Kami C., Millar, Jane, Asowata, Osaretin E., Ngoepe, Abigail, Ramsuran, Duran, Fardoos, Rabiah, Ardain, Amanda, Muenchhoff, Maximilian, Kuhn, Warren, Karim, Farina, Ndung’u, Thumbi, Shalek, Alex K., Goulder, Philip, Leslie, Alasdair, Kløverpris, Henrik N.

“…Innate lymphoid cells (ILCs) are important for response to infection and for immune development in early life. HIV infection in adults depletes circulating…”
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Early Antigen Presentation of Protective HIV-1 KF11Gag and KK10Gag Epitopes from Incoming Viral Particles Facilitates Rapid Recognition of Infected Cells by Specific CD8+ T Cells by Kløverpris, Henrik N., Payne, Rebecca P., Sacha, Jonah B., Rasaiyaah, Jane T., Chen, Fabian, Takiguchi, Masafumi, Yang, Otto O., Towers, Greg J., Goulder, Philip, Prado, Julia G.

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Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection by Nunes-Alves, Cláudio, Booty, Matthew G, Carpenter, Stephen M, Rothchild, Alissa C, Martin, Constance J, Desjardins, Danielle, Steblenko, Katherine, Kløverpris, Henrik N, Madansein, Rajhmun, Ramsuran, Duran, Leslie, Alasdair, Correia-Neves, Margarida, Behar, Samuel M

“…The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to…”
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Differential Clade-Specific HLA-B3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope by MATTHEWS, Philippa C, KOYANAGI, Madoka, AVILA RIOS, Santiago, COLE, David, CARLSON, Jonathan, PAYNE, Rebecca P, OGWU, Anthony, BERE, Alfred, NDUNG'U, Thumbi, GOUNDER, Kamini, FABIAN CHEN, RIDDELL, Lynn, KLØVERPRIS, Henrik N, LUZZI, Graz, SHAPIRO, Roger, BRANDER, Christian, WALKER, Bruce, SEWELL, Andrew K, REYES TERAN, Gustavo, HECKERMAN, David, HUNTER, Eric, BUUS, Soren, TAKIGUCHI, Masafumi, HARNDAHL, Mikkel, GOULDER, Philip J. R, STRYHN, Anette, AKAHOSHI, Tomohiro, GATANAGA, Hiroyuki, OKA, Shinichi, JUAREZ MOLINA, Claudia, VALENZUELA PONCE, Humberto

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Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis by Ardain, Amanda, Domingo-Gonzalez, Racquel, Das, Shibali, Kazer, Samuel W., Howard, Nicole C., Singh, Alveera, Ahmed, Mushtaq, Nhamoyebonde, Shepherd, Rangel-Moreno, Javier, Ogongo, Paul, Lu, Lan, Ramsuran, Duran, de la Luz Garcia-Hernandez, Maria, K. Ulland, Tyler, Darby, Matthew, Park, Eugene, Karim, Farina, Melocchi, Laura, Madansein, Rajhmun, Dullabh, Kaylesh Jay, Dunlap, Micah, Marin-Agudelo, Nancy, Ebihara, Takashi, Ndung’u, Thumbi, Kaushal, Deepak, Pym, Alexander S., Kolls, Jay K., Steyn, Adrie, Zúñiga, Joaquín, Horsnell, William, Yokoyama, Wayne M., Shalek, Alex K., Kløverpris, Henrik N., Colonna, Marco, Leslie, Alasdair, Khader, Shabaana A.

“…Tuberculosis is the leading cause of death by an infectious disease worldwide 1 . However, the involvement of innate lymphoid cells (ILCs) in immune responses…”
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CD8+ TCR Bias and Immunodominance in HIV-1 Infection by Kløverpris, Henrik N, McGregor, Reuben, McLaren, James E, Ladell, Kristin, Harndahl, Mikkel, Stryhn, Anette, Carlson, Jonathan M, Koofhethile, Catherine, Gerritsen, Bram, Keşmir, Can, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Leslie, Alasdair, Walker, Bruce D, Ndung'u, Thumbi, Buus, Søren, Price, David A, Goulder, Philip J

“…Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available Ag pool derived from a given pathogen…”
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Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression by Kløverpris, Henrik N., Kazer, Samuel W., Mjösberg, Jenny, Mabuka, Jenniffer M., Wellmann, Amanda, Ndhlovu, Zaza, Yadon, Marisa C., Nhamoyebonde, Shepherd, Muenchhoff, Maximilian, Simoni, Yannick, Andersson, Frank, Kuhn, Warren, Garrett, Nigel, Burgers, Wendy A., Kamya, Philomena, Pretorius, Karyn, Dong, Krista, Moodley, Amber, Newell, Evan W., Kasprowicz, Victoria, Abdool Karim, Salim S., Goulder, Philip, Shalek, Alex K., Walker, Bruce D., Ndung’u, Thumbi, Leslie, Alasdair

“…Innate lymphoid cells (ILCs) play a central role in the response to infection by secreting cytokines crucial for immune regulation, tissue homeostasis, and…”
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HIV Control through a Single Nucleotide on the HLA-B Locus by Kløverpris, Henrik N, Harndahl, Mikkel, Leslie, Alasdair J, Carlson, Jonathan M, Ismail, Nasreen, van der Stok, Mary, Huang, Kuan-Hsiang Gary, Chen, Fabian, Riddell, Lynn, Steyn, Dewald, Goedhals, Dominique, van Vuuren, Cloete, Frater, John, Walker, Bruce D, Carrington, Mary, Ndung'u, Thumbi, Buus, Søren, Goulder, Philip

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Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection by Asowata, Osaretin E, Singh, Alveera, Ngoepe, Abigail, Herbert, Nicholas, Fardoos, Rabiah, Reddy, Kavidha, Zungu, Yenzekile, Nene, Faith, Mthabela, Ntombifuthi, Ramjit, Dirhona, Karim, Farina, Govender, Katya, Ndung'u, Thumbi, Porterfield, J Zachary, Adamson, John H, Madela, Fusi G, Manzini, Vukani T, Anderson, Frank, Leslie, Alasdair, Kløverpris, Henrik N

“…HIV infection in the human gastrointestinal (GI) tract is thought to be central to HIV progression, but knowledge of this interaction is primarily limited to…”
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Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype by Vieira, Vinicius, Lim, Nicholas, Singh, Alveera, Leitman, Ellen, Dsouza, Reena, Adland, Emily, Muenchhoff, Maximilian, Roider, Julia, Marin Lopez, Miguel, Carabelli, Julieta, Giandhari, Jennifer, Groll, Andreas, Jooste, Pieter, Prado, Julia G, Thobakgale, Christina, Dong, Krista, Kiepiela, Photini, Prendergast, Andrew J, Tudor-Williams, Gareth, Frater, John, Walker, Bruce D, Ndung'u, Thumbi, Ramsuran, Veron, Leslie, Alasdair, Kløverpris, Henrik N, Goulder, Philip

“…HIV nonprogression despite persistent viremia is rare among adults who are naive to antiretroviral therapy (ART) but relatively common among ART-naive…”
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Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life by Attaf, Meriem, Roider, Julia, Malik, Amna, Rafael, Cristina Rius, Dolton, Garry, Prendergast, Andrew J, Leslie, Alasdair, Ndung'u, Thumbi, Kløverpris, Henrik N, Sewell, Andrew K, Goulder, Philip J

“…[This corrects the article DOI: 10.3389/fimmu.2020.01587.]…”
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HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells by Fardoos, Rabiah, Asowata, Osaretin E., Herbert, Nicholas, Nyquist, Sarah K., Zungu, Yenzekile, Singh, Alveera, Ngoepe, Abigail, Mbano, Ian M., Mthabela, Ntombifuthi, Ramjit, Dirhona, Karim, Farina, Kuhn, Warren, Madela, Fusi G., Manzini, Vukani T., Anderson, Frank, Berger, Bonnie, Pers, Tune H., Shalek, Alex K., Leslie, Alasdair, Kløverpris, Henrik N.

“…SARS-CoV-2 infects epithelial cells of the human gastrointestinal (GI) tract and causes related symptoms. HIV infection impairs gut homeostasis and is…”
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