Search Results - "Kjell, Fuxe"

The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural-glial networks by Borroto-Escuela, Dasiel O., Agnati, Luigi F., Bechter, Karl, Jansson, Anders, Tarakanov, Alexander O., Fuxe, Kjell

“…Two major types of intercellular communication are found in the central nervous system (CNS), namely wiring transmission (point-to-point communication, the…”
Get full text

The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects by Borroto-Escuela, Dasiel O, Ambrogini, Patrizia, Chruścicka, Barbara, Lindskog, Maria, Crespo-Ramirez, Minerva, Hernández-Mondragón, Juan C, Perez de la Mora, Miguel, Schellekens, Harriët, Fuxe, Kjell

“…Serotonin communication operates mainly in the extracellular space and cerebrospinal fluid (CSF), using volume transmission with serotonin moving from source…”
Get full text

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia by Navarro, Gemma, Borroto-Escuela, Dasiel, Angelats, Edgar, Etayo, Íñigo, Reyes-Resina, Irene, Pulido-Salgado, Marta, Rodríguez-Pérez, Ana I., Canela, Enric I., Saura, Josep, Lanciego, José Luis, Labandeira-García, José Luis, Saura, Carlos A., Fuxe, Kjell, Franco, Rafael

“…•LPS plus interferon-γ upregulate CB2 receptors in microglia.•LPS plus interferon-γ upregulate CB1-CB2 receptor complexes in microglia.•ß amyloid and LPS plus…”
Get full text

Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets by Fuxe, Kjell, Agnati, Luigi F., Marcoli, Manuela, Borroto-Escuela, Dasiel O.

“…Already in the 1960s the architecture and pharmacology of the brainstem dopamine (DA) and noradrenaline (NA) neurons with formation of vast numbers of DA and…”
Get full text

A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction by Borroto-Escuela, Dasiel O., Wydra, Karolina, Filip, Malgorzata, Fuxe, Kjell

“…The concept of allosteric receptor–receptor interactions in G protein-coupled receptor homo- and heteroreceptor complexes in which they physically interact…”
Get full text

Purinergic signaling in Parkinson's disease. Relevance for treatment by Navarro, Gemma, Borroto-Escuela, Dasiel O., Fuxe, Kjell, Franco, Rafael

“…Purinergic signaling modulates dopaminergic neurotransmission in health and disease. Classically adenosine A1 and A2A receptors have been considered key for…”
Get full text

The discovery of central monoamine neurons gave volume transmission to the wired brain by Fuxe, Kjell, Dahlström, Annica B, Jonsson, Gösta, Marcellino, Daniel, Guescini, Michele, Dam, Mauro, Manger, Paul, Agnati, Luigi

“…The dawn of chemical neuroanatomy in the CNS came with the discovery and mapping of the central dopamine, noradrenaline and 5-hydroxytryptamine neurons by…”
Get full text

Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis by de la Mora, Miguel Pérez, Gallegos-Cari, Andrea, Arizmendi-García, Yexel, Marcellino, Daniel, Fuxe, Kjell

“…Dopamine plays an important role in fear and anxiety modulating a cortical brake that the medial prefrontal cortex exerts on the anxiogenic output of the…”
Get full text

Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS by Borroto-Escuela, Dasiel O., Fuxe, Kjell

“…GPCRs not only exist as monomers but also as homomers and heteromers in which allosteric receptor-receptor interactions take place modulating the functions of…”
Get full text

A2A‐D2 receptor–receptor interaction modulates gliotransmitter release from striatal astrocyte processes by Cervetto, Chiara, Venturini, Arianna, Passalacqua, Mario, Guidolin, Diego, Genedani, Susanna, Fuxe, Kjell, Borroto‐Esquela, Dasiel O., Cortelli, Pietro, Woods, Amina, Maura, Guido, Marcoli, Manuela, Agnati, Luigi F.

“…Evidence for striatal A2A‐D2 heterodimers has led to a new perspective on molecular mechanisms involved in schizophrenia and Parkinson's disease. Despite the…”
Get full text

Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease by Borroto-Escuela, Dasiel O, Carlsson, Jens, Ambrogini, Patricia, Narváez, Manuel, Wydra, Karolina, Tarakanov, Alexander O, Li, Xiang, Millón, Carmelo, Ferraro, Luca, Cuppini, Riccardo, Tanganelli, Sergio, Liu, Fang, Filip, Malgorzata, Diaz-Cabiale, Zaida, Fuxe, Kjell

“…The introduction of allosteric receptor-receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the central nervous system (CNS)…”
Get full text

Amplification of potential thermogenetic mechanisms in cetacean brains compared to artiodactyl brains by Manger, Paul R., Patzke, Nina, Spocter, Muhammad A., Bhagwandin, Adhil, Karlsson, Karl Æ., Bertelsen, Mads F., Alagaili, Abdulaziz N., Bennett, Nigel C., Mohammed, Osama B., Herculano-Houzel, Suzana, Hof, Patrick R., Fuxe, Kjell

“…To elucidate factors underlying the evolution of large brains in cetaceans, we examined 16 brains from 14 cetartiodactyl species, with immunohistochemical…”
Get full text

5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression by Ambrogini, Patrizia, Lattanzi, Davide, Pagliarini, Marica, Di Palma, Michael, Sartini, Stefano, Cuppini, Riccardo, Fuxe, Kjell, Borroto-Escuela, Dasiel Oscar

“…The midbrain raphe serotonin (5HT) neurons provide the main ascending serotonergic projection to the forebrain, including hippocampus, which has a role in the…”
Get full text

Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer by Borroto-Escuela, Dasiel O., Rodriguez, David, Romero-Fernandez, Wilber, Kapla, Jon, Jaiteh, Mariama, Ranganathan, Anirudh, Lazarova, Tzvetana, Fuxe, Kjell, Carlsson, Jens

“…The A 2A adenosine (A 2A R) and D 2 dopamine (D 2 R) receptors form oligomers in the cell membrane and allosteric interactions across the A 2A R–D 2 R…”
Get full text

Detection of heteromerization of more than two proteins by sequential BRET-FRET by Cortés, Antoni, Franco, Rafael, Mallol, Josefa, Carriba, Paulina, Fuxe, Kjell, Lluís, Carmen, Canela, Enric I, Navarro, Gemma, Ciruela, Francisco, Casadó, Vicent, Agnati, Luigi, Ferré, Sergi

“…Many proteins, including G protein–coupled receptors (GPCRs), interact to form oligomers at the cell surface. A combination of bioluminescence resonance energy…”
Get full text

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components by Borroto-Escuela, Dasiel O, Brito, Ismel, Romero-Fernandez, Wilber, Di Palma, Michael, Oflijan, Julia, Skieterska, Kamila, Duchou, Jolien, Van Craenenbroeck, Kathleen, Suárez-Boomgaard, Diana, Rivera, Alicia, Guidolin, Diego, Agnati, Luigi F, Fuxe, Kjell

“…G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the…”
Get full text

G protein-coupled receptor heterodimerization in the brain by Borroto-Escuela, Dasiel O, Romero-Fernandez, Wilber, Garriga, Pere, Ciruela, Francisco, Narvaez, Manuel, Tarakanov, Alexander O, Palkovits, Miklós, Agnati, Luigi F, Fuxe, Kjell

“…G protein-coupled receptors (GPCRs) play critical roles in cellular processes and signaling and have been shown to form heteromers with diverge biochemical…”
Get more information

Volume transmission and receptor-receptor interactions in heteroreceptor complexes：understanding the role of new concepts for brain communication by Fuxe, Kjell, Borroto-Escuela, Dasiel

“…The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and…”
Get full text

Direct involvement of σ-1 receptors in the dopamine D₁ receptor-mediated effects of cocaine by Navarro, Gemma, Moreno, Estefanía, Aymerich, Marisol, Marcellino, Daniel, McCormick, Peter J, Mallol, Josefa, Cortés, Antoni, Casadó, Vicent, Canela, Enric I, Ortiz, Jordi, Fuxe, Kjell, Lluís, Carmen, Ferré, Sergi, Franco, Rafael

“…It is well known that cocaine blocks the dopamine transporter. This mechanism should lead to a general increase in dopaminergic neurotransmission, and yet…”
Get full text

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation by Borroto-Escuela, Dasiel O, Hinz, Sonja, Navarro, Gemma, Franco, Rafael, Müller, Christa E, Fuxe, Kjell

“…Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a…”
Get full text