Search Results - "Kizziah, James L."

Structure of the host cell recognition and penetration machinery of a Staphylococcus aureus bacteriophage by Kizziah, James L, Manning, Keith A, Dearborn, Altaira D, Dokland, Terje

“…Staphylococcus aureus is a common cause of infections in humans. The emergence of virulent, antibiotic-resistant strains of S. aureus is a significant public…”
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Shape shifter: redirection of prolate phage capsid assembly by staphylococcal pathogenicity islands by Hawkins, N’Toia C., Kizziah, James L., Penadés, José R., Dokland, Terje

“…Staphylococcus aureus pathogenicity islands (SaPIs) are molecular parasites that hijack helper phages for their transfer. SaPIbov5, the prototypical member of…”
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Structure of the Capsid Size-Determining Scaffold of "Satellite" Bacteriophage P4 by Kizziah, James L, Rodenburg, Cynthia M, Dokland, Terje

“…P4 is a mobile genetic element (MGE) that can exist as a plasmid or integrated into its host genome, but becomes packaged into phage particles by a helper…”
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Competing scaffolding proteins determine capsid size during mobilization of Staphylococcus aureus pathogenicity islands by Dearborn, Altaira D, Wall, Erin A, Kizziah, James L, Klenow, Laura, Parker, Laura K, Manning, Keith A, Spilman, Michael S, Spear, John M, Christie, Gail E, Dokland, Terje

“…pathogenicity islands (SaPIs), such as SaPI1, exploit specific helper bacteriophages, like 80α, for their high frequency mobilization, a process termed…”
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Transient sampling of aggregation‐prone conformations causes pathogenic instability of a parkinsonian mutant of DJ‐1 at physiological temperature by Milkovic, Nicole M., Catazaro, Jonathan, Lin, Jiusheng, Halouska, Steven, Kizziah, James L., Basiaga, Sara, Cerny, Ronald L., Powers, Robert, Wilson, Mark A.

“…Various missense mutations in the cytoprotective protein DJ‐1 cause rare forms of inherited parkinsonism. One mutation, M26I, diminishes DJ‐1 protein levels in…”
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Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants by Piepenbrink, Michael S., Khalil, Ahmed Magdy, Chang, Ana, Mostafa, Ahmed, Basu, Madhubanti, Sarkar, Sanghita, Panjwani, Simran, Ha, Yaelyn H., Ma, Yao, Ye, Chengjin, Wang, Qian, Green, Todd J., Kizziah, James L., Erdmann, Nathaniel B., Goepfert, Paul A., Liu, Lihong, Ho, David D., Martinez-Sobrido, Luis, Walter, Mark R., Kobie, James J.

“…SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By…”
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Cleavage and Structural Transitions during Maturation of Staphylococcus aureus Bacteriophage 80α and SaPI1 Capsids by Kizziah, James L, Manning, Keith A, Dearborn, Altaira D, Wall, Erin A, Klenow, Laura, Hill, Rosanne L L, Spilman, Michael S, Stagg, Scott M, Christie, Gail E, Dokland, Terje

“…In the tailed bacteriophages, DNA is packaged into spherical procapsids, leading to expansion into angular, thin-walled mature capsids. In many cases, this…”
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Structure of the Portal Complex from Staphylococcus aureus Pathogenicity Island 1 Transducing Particles In Situ and In Isolation by Mukherjee, Amarshi, Kizziah, James L., Hawkins, N'Toia C., Nasef, Mohamed O., Parker, Laura K., Dokland, Terje

“…[Display omitted] •The phage portal plays key roles in capsid assembly, DNA packaging and ejection.•Cryo-EM reveals the structure of the 80α portal in…”
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Structure and host specificity of Staphylococcus epidermidis bacteriophage Andhra by Hawkins, N'Toia C, Kizziah, James L, Hatoum-Aslan, Asma, Dokland, Terje

“…is an opportunistic pathogen of the human skin, often associated with infections of implanted medical devices. Staphylococcal picoviruses are a group of…”
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Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold by Crowley, Vincent M, Khandelwal, Anuj, Mishra, Sanket, Stothert, Andrew R, Huard, Dustin J. E, Zhao, Jinbo, Muth, Aaron, Duerfeldt, Adam S, Kizziah, James L, Lieberman, Raquel L, Dickey, Chad A, Blagg, Brian S. J

“…Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94…”
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Heads or Tails? Structural Studies of Host Interaction and Molecular Piracy in Bacteriophages by Kizziah, James L

“…Staphylococcus aureus is an opportunistic human pathogen dependent mainly on bacteriophages (phages) for dissemination of the virulence factors that contribute…”
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