Search Results - "Kizindo, Robert"
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Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial
Published in PloS one (07-12-2012)“…Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that…”
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Anthelminthic treatment receipt and its predictors in Lake Victoria fishing communities, Uganda: Intervention coverage results from the LaVIISWA cluster randomised trial
Published in PLoS neglected tropical diseases (01-10-2020)“…Mass drug administration (MDA) is a cornerstone of control of parasitic helminths. In schistosomiasis-endemic areas with >50% of school-aged children infected,…”
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Population differences in vaccine responses (POPVAC): scientific rationale and cross-cutting analyses for three linked, randomised controlled trials assessing the role, reversibility and mediators of immunomodulation by chronic infections in the tropics
Published in BMJ open (16-02-2021)“…IntroductionVaccine-specific immune responses vary between populations and are often impaired in low income, rural settings. Drivers of these differences are…”
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Determining Mycobacterium tuberculosis infection among BCG-immunised Ugandan children by T-SPOT.TB and tuberculin skin testing
Published in PloS one (15-10-2012)“…Children with latent tuberculosis infection (LTBI) represent a huge reservoir for future disease. We wished to determine Mycobacterium tuberculosis (M.tb)…”
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The role of the home environment in neurocognitive development of children living in extreme poverty and with frequent illnesses: a cross-sectional study
Published in Wellcome open research (2018)“…The home environment is reported to contribute significantly to children's developing cognitive skills. However, it is not yet evident whether this role…”
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The Effect of Helminth Infections and Their Treatment on Metabolic Outcomes: Results of a Cluster-Randomized Trial
Published in Clinical infectious diseases (27-07-2020)“…Abstract Background Helminths may protect against cardiometabolic risk through effects on inflammation and metabolism; their treatment may be detrimental to…”
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Epidemiology of Alcohol Misuse and Illicit Drug Use Among Young People Aged 15-24 Years in Fishing Communities in Uganda
Published in International journal of environmental research and public health (01-04-2020)“…We determined the prevalence of and risk factors for alcohol misuse and illicit drug use among young Ugandans in fishing communities, a recognised "key…”
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Do helminth infections underpin urban‐rural differences in risk factors for allergy‐related outcomes?
Published in Clinical and experimental allergy (01-05-2019)“…Summary Background It is proposed that helminth exposure protects against allergy‐related disease, by mechanisms that include disconnecting risk factors (such…”
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The Impact of Intensive Versus Standard Anthelminthic Treatment on Allergy-related Outcomes, Helminth Infection Intensity, and Helminth-related Morbidity in Lake Victoria Fishing Communities, Uganda: Results From the LaVIISWA Cluster-randomized Trial
Published in Clinical infectious diseases (02-05-2019)“…Abstract Background The prevalence of allergy-related diseases is increasing in low-income countries. Parasitic helminths, common in these settings, may be…”
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The effect of intermittent preventive treatment for malaria with dihydroartemisinin–piperaquine on vaccine-specific responses among schoolchildren in rural Uganda (POPVAC B): a double-blind, randomised controlled trial
Published in The Lancet global health (01-11-2024)“…Several important vaccines differ in immunogenicity and efficacy between populations. We hypothesised that malaria suppresses responses to unrelated vaccines…”
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The effect of BCG revaccination on the response to unrelated vaccines in urban Ugandan adolescents (POPVAC C): an open-label, randomised controlled trial
Published in The Lancet global health (01-11-2024)“…Immune responses induced by several important vaccines differ between populations, with reduced responses in low-income and rural settings compared with…”
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Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial
Published in The Lancet (British edition) (2011)“…Summary Background Helminth infections affect the human immune response. We investigated whether prenatal exposure to and treatment of maternal helminth…”
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Effect of intermittent preventive treatment for malaria with dihydroartemisinin-piperaquine on immune responses to vaccines among rural Ugandan adolescents: randomised controlled trial protocol B for the ' POP ulation differences in VAC cine responses' (POPVAC) programme
Published in BMJ open (16-02-2021)“…Drivers of lower vaccine efficacy and impaired vaccine-specific immune responses in low-income versus high-income countries, and in rural compared with urban…”
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Schistosome and malaria exposure and urban–rural differences in vaccine responses in Uganda: a causal mediation analysis using data from three linked randomised controlled trials
Published in The Lancet global health (01-11-2024)“…Vaccine immunogenicity and effectiveness vary geographically. Chronic immunomodulating parasitic infections including schistosomes and malaria have been…”
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The effect of intensive praziquantel administration on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands (POPVAC A): an open-label, randomised controlled trial
Published in The Lancet global health (01-11-2024)“…Vaccine responses differ between populations and are often impaired in rural and low-income settings. The reasons for this are not fully understood, but…”
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Impact of BCG revaccination on the response to unrelated vaccines in a Ugandan adolescent birth cohort: randomised controlled trial protocol C for the ‘POPulation differences in VACcine responses’ (POPVAC) programme
Published in BMJ open (16-02-2021)“…IntroductionThere is evidence that BCG immunisation may protect against unrelated infectious illnesses. This has led to the postulation that administering BCG…”
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Effect of intensive treatment for schistosomiasis on immune responses to vaccines among rural Ugandan island adolescents: randomised controlled trial protocol A for the ' POP ulation differences in VAC cine responses' (POPVAC) programme
Published in BMJ open (16-02-2021)“…Several licensed and investigational vaccines have lower efficacy, and induce impaired immune responses, in low-income versus high-income countries and in…”
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Plasmodium falciparum and Helminth Coinfection in a Semiurban Population of Pregnant Women in Uganda
Published in The Journal of infectious diseases (15-09-2008)“…Background. Helminth infections and malaria are widespread in the tropics. Recent studies suggest helminth infections may increase susceptibility to Plasmodium…”
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The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette–Guérin immunization
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (19-06-2015)“…Bacille Calmette–Guérin (BCG) immunization provides variable protection against tuberculosis. Prenatal antigen exposure may have lifelong effects on responses…”
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Schistosoma mansoni and HIV infection in a Ugandan population with high HIV and helminth prevalence
Published in Tropical medicine & international health (01-09-2015)“…Objectives Recent reports suggest that Schistosoma infection may increase the risk of acquiring human immunodeficiency virus (HIV). We used data from a large…”
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