Search Results - "Kizina, Kathrin"

Response properties of the genetically encoded optical H2O2 sensor HyPer by Weller, Jonathan, Kizina, Kathrin M, Can, Karolina, Bao, Guobin, Müller, Michael

“…Reactive oxygen species mediate cellular signaling and neuropathologies. Hence, there is tremendous interest in monitoring (sub)cellular redox conditions. We…”
Get full text

Nusinersen treatment in adult patients with spinal muscular atrophy: a safety analysis of laboratory parameters by Stolte, Benjamin, Nonnemacher, Michael, Kizina, Kathrin, Bolz, Saskia, Totzeck, Andreas, Thimm, Andreas, Wagner, Bernd, Deuschl, Cornelius, Kleinschnitz, Christoph, Hagenacker, Tim

“…Background Nusinersen is an intrathecally administered antisense oligonucleotide (ASO) that improves motor function in patients with spinal muscular atrophy…”
Get full text

Feasibility and safety of intrathecal treatment with nusinersen in adult patients with spinal muscular atrophy by Stolte, Benjamin, Totzeck, Andreas, Kizina, Kathrin, Bolz, Saskia, Pietruck, Lena, Mönninghoff, Christoph, Guberina, Nika, Oldenburg, Denise, Forsting, Michael, Kleinschnitz, Christoph, Hagenacker, Tim

“…Background: Nusinersen is an intrathecally administered antisense oligonucleotide (ASO) and the first approved drug for the treatment of spinal muscular…”
Get full text

Neurofilament Heavy Chain and Tau Protein Are Not Elevated in Cerebrospinal Fluid of Adult Patients with Spinal Muscular Atrophy during Loading with Nusinersen by Totzeck, Andreas, Stolte, Benjamin, Kizina, Kathrin, Bolz, Saskia, Schlag, Melina, Thimm, Andreas, Kleinschnitz, Christoph, Hagenacker, Tim

“…Nusinersen is the first approved drug for the treatment of spinal muscular atrophy (SMA). Treatment of SMA with nusinersen is based on a fixed dosing regimen…”
Get full text

Assessment of Health-Related Quality of Life in Adult Spinal Muscular Atrophy Under Nusinersen Treatment-A Pilot Study by Thimm, Andreas, Brakemeier, Svenja, Kizina, Kathrin, Munoz Rosales, Juan, Stolte, Benjamin, Totzeck, Andreas, Deuschl, Cornelius, Kleinschnitz, Christoph, Hagenacker, Tim

“…5q-Spinal muscular atrophy (SMA) is a severely disabling inherited neuromuscular disease that progressively reduces the motor abilities of affected…”
Get full text

Redox Indicator Mice Stably Expressing Genetically Encoded Neuronal roGFP: Versatile Tools to Decipher Subcellular Redox Dynamics in Neuropathophysiology by Wagener, Kerstin C, Kolbrink, Benedikt, Dietrich, Katharina, Kizina, Kathrin M, Terwitte, Lukas S, Kempkes, Belinda, Bao, Guobin, Müller, Michael

“…Reactive oxygen species (ROS) and downstream redox alterations not only mediate physiological signaling but also neuropathology. For long, ROS/redox imaging…”
Get more information

Gut bacterial microbiota in patients with myasthenia gravis: results from the MYBIOM study by Totzeck, Andreas, Ramakrishnan, Elakiya, Schlag, Melina, Stolte, Benjamin, Kizina, Kathrin, Bolz, Saskia, Thimm, Andreas, Stettner, Mark, Marchesi, Julian R., Buer, Jan, Kleinschnitz, Christoph, Verhasselt, Hedda Luise, Hagenacker, Tim

“…Background: Myasthenia gravis (MG) is an autoimmune neuromuscular disease, with gut microbiota considered to be a pathogenetic factor. Previous pilot studies…”
Get full text

Clinical Implication of Dosimetry of Computed Tomography- and Fluoroscopy-Guided Intrathecal Therapy With Nusinersen in Adult Patients With Spinal Muscular Atrophy by Kizina, Kathrin, Stolte, Benjamin, Totzeck, Andreas, Bolz, Saskia, Fleischer, Michael, Mönninghoff, Christoph, Guberina, Nika, Oldenburg, Denise, Forsting, Michael, Kleinschnitz, Christoph, Hagenacker, Tim

“…Background: Spinal muscular atrophy (SMA) is a genetic disorder that leads to progressive tetraparesis. Nusinersen is the first approved drug for the treatment…”
Get full text

Assessment of Bulbar Function in Adult Patients with 5q-SMA Type 2 and 3 under Treatment with Nusinersen by Brakemeier, Svenja, Stolte, Benjamin, Thimm, Andreas, Kizina, Kathrin, Totzeck, Andreas, Munoz-Rosales, Juan, Kleinschnitz, Christoph, Hagenacker, Tim

“…The antisense oligonucleotide nusinersen has been shown to improve trunk and limb motor function in patients with spinal muscular atrophy (SMA). Bulbar…”
Get full text

Cognitive Impairment in Adult Patients with 5q-Associated Spinal Muscular Atrophy by Kizina, Kathrin, Akkaya, Yakup, Jokisch, Daniel, Stolte, Benjamin, Totzeck, Andreas, Munoz-Rosales, Juan, Thimm, Andreas, Bolz, Saskia, Brakemeier, Svenja, Pul, Refik, Aslan, Derya, Hackert, Jana, Kleinschnitz, Christoph, Hagenacker, Tim

“…In previous studies, a below-average, average, or above-average intelligence quotient (IQ) in children with SMA was detected but, aside from a severe physical…”
Get full text

Detect it so you can treat it: A case series and proposed checklist to detect neurotoxicity in checkpoint therapy by Bolz, Saskia, Ramakrishnan, Thivyah, Fleischer, Michael, Livingstone, Elisabeth, Stolte, Benjamin, Thimm, Andreas, Kizina, Kathrin, Ugurel, Selma, Kleinschnitz, Christoph, Glas, Martin, Zimmer, Lisa, Hagenacker, Tim

“…Checkpoint inhibitors show impressive and durable responses in various cancer types and provide new avenues for cancer immunotherapy. However, these drugs have…”
Get full text

Nusinersen in adults with 5q spinal muscular atrophy: a non-interventional, multicentre, observational cohort study by Hagenacker, Tim, Wurster, Claudia D, Günther, René, Schreiber-Katz, Olivia, Osmanovic, Alma, Petri, Susanne, Weiler, Markus, Ziegler, Andreas, Kuttler, Josua, Koch, Jan C, Schneider, Ilka, Wunderlich, Gilbert, Schloss, Natalie, Lehmann, Helmar C, Cordts, Isabell, Deschauer, Marcus, Lingor, Paul, Kamm, Christoph, Stolte, Benjamin, Pietruck, Lena, Totzeck, Andreas, Kizina, Kathrin, Mönninghoff, Christoph, von Velsen, Otgonzul, Ose, Claudia, Reichmann, Heinz, Forsting, Michael, Pechmann, Astrid, Kirschner, Janbernd, Ludolph, Albert C, Hermann, Andreas, Kleinschnitz, Christoph

“…Nusinersen is approved for the treatment of 5q spinal muscular atrophy of all types and stages in patients of all ages. Although clinical trials have shown…”
Get full text