Search Results - "Kizer, J S"

An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes by Busby, W H, Quackenbush, G E, Humm, J, Youngblood, W W, Kizer, J S

“…The mechanism for the post-translational conversion of glutamine to pyroglutamic acid on the N terminus of newly synthesized peptides and proteins is unknown…”
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Computer‐facilitated Review of Electronic Medical Records Reliably Identifies Emergency Department Interventions in Older Adults by Biese, Kevin J., Forbach, Cory R., Medlin, Richard P., Platts‐Mills, Timothy F., Scholer, Matthew J., McCall, Brenda, Shofer, Frances S., LaMantia, Michael, Hobgood, Cherri, Kizer, J. S., Busby‐Whitehead, Jan, Cairns, Charles B., Shah, Manish N.

“…Objectives An estimated 14% to 25% of all scientific studies in peer‐reviewed emergency medicine (EM) journals are medical records reviews. The majority of the…”
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Identification and immunocytochemical localization of a new thyrotropin-releasing hormone precursor in rat brain by Merchenthaler, I, Meeker, M, Petrusz, P, Kizer, J S

“…Antisera were raised to a tridecapeptide, Ser-Asp-Val-Thr-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Phe, that was synthesized based on the sequence (residues 166-178) of…”
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A motif found in propeptides and prohormones that may target them to secretory vesicles by Kizer, J S, Tropsha, A

“…Sorting of prohormones and propeptides into secretory vesicles at the trans-Golgi face probably depends on a signal contained within the amino acid sequence of…”
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Do Interhelical Side Chain-Backbone Hydrogen Bonds Participate in Formation of Leucine Zipper Coiled Coils? by Tropsha, Alexander, Bowen, J. Phillip, Brown, Frank K., Kizer, J. S.

“…The leucine zipper proteins are a group of transcriptional regulators that dimerize to form a DNA binding domain. It has been proposed that this dimerization…”
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Nonenzymatic peptide alpha-amidation. Implications for a novel enzyme mechanism by Bateman, R C, Youngblood, W W, Busby, W H, Kizer, J S

“…An abiotic system is described which chemically catalyzes the formation of less than Glu-His-Pro-NH2 (thyrotropin-releasing hormone) from less than…”
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Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients: normalization after neuroleptic treatment by Widerlöv, E, Lindström, L H, Besev, G, Manberg, P J, Nemeroff, C B, Breese, G R, Kizer, J S, Prange, Jr, A J

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Regional Brain Concentrations of Neuropeptides in Huntington's Chorea and Schizophrenia by Nemeroff, Charles B., Youngblood, William W., Manberg, Paul J., Prange, Arthur J., Kizer, John S.

“…To ascertain whether Huntington's chorea and schizophrenia are associated with specific regional alterations in neurotensin, somatostatin, and…”
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Glycine-Directed Peptide Amidation: Presence in Rat Brain of two Enzymes That Convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2(Thyrotropin-Releasing Hormone) by Kizer, J. S., Busby, W. H., Cottle, C., Youngblood, W. W.

“…To study the possibility of glycine-directed amidation in rat brain, we synthesized the substrate p-Glu-His-Pro-Gly-OH. Adult and neonatal rat brain and adult…”
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Neuropeptides in Alzheimer's disease: a postmortem study by Nemeroff, C B, Kizer, J S, Reynolds, G P, Bissette, G

“…The concentration of 5 neuropeptides, neurotensin (NT), somatostatin (SRIF), corticotropin-releasing factor (CRF), bombesin and thyrotropin-releasing hormone…”
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Purification and characterization of a peptidyl glycine monooxygenase from porcine pituitary by Kizer, J S, Bateman, Jr, R C, Miller, C R, Humm, J, Busby, Jr, W H, Youngblood, W W

“…A peptide alpha-amidating enzyme was purified to apparent homogeneity from porcine pituitary. This enzyme is a glycoprotein with a mol wt of 64,000, a metal…”
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Alterations in regional brain concentrations of neurotensin and bombesin in Parkinson's disease by Bissette, G, Nemeroff, C B, Decker, M W, Kizer, J S, Agid, Y, Javoy-Agid, F

“…Frozen samples of postmortem human brain tissue from patients with Parkinson's disease (n = 25) and control patients who died without neurological disease (n =…”
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Ontogeny of brain neurotensin in the rat: a radioimmunoassay study by Bissette, G, Richardson, C, Kizer, J S, Nemeroff, C B

“…Concentrations of neurotensin-like immunoreactivity in several discrete brain areas were measured by radioimmunoassay in rats of different ages (2, 5, 10, 20,…”
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The projections of the A8, A9 and A10 dopaminergic cell bodies: evidence for a nigral-hypothalamic-median eminence dopaminergic pathway by Kizer, J S, Palkovits, M, Brownstein, M J

“…Using the microdissection method of Palkovits and a sensitive microassay for dopamine (DA) and norepinephrine (NE), the CNS projections of the nigral A8, A9…”
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Assay of peptidylglycine monooxygenase: glycine-directed amidating enzyme by Brock, T, Humm, J, Kizer, J S

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Distribution of biogenic amines and related enzymes in the rat pituitary gland by Saavedra, J M, Palkovits, M, Kizer, J S, Brownstein, M, Zivin, J A

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Effects of castration and adrenalectomy on in vitro rates of tryptophan hydroxylation and levels of serotonin in microdissected brain nuclei of adult male rats by Long, J B, Youngblood, W W, Kizer, J S

“…Rates of 5-hydroxytryptophan (5-HTP) synthesis and levels of serotonin (5-HT) were measured in microdissected brain nuclei following castration or…”
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Effect of Hypothalamic Deafferentation on Thyrotropin-Releasing Hormone Levels in Rat Brain by Brownstein, M. J., Utiger, R. D., Palkovits, M., Kizer, J. S.

“…The medial basal hypothalamus was isolated from the remainder of the brain of the rat using a Halasz knife. Ten to 14 days after the surgical procedure the…”
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The regulation of enkephalin levels in adrenomedullary cells and its relation to chromaffin vesicle biogenesis and functional plasticity by Viveros, O H, Diliberto, Jr, E J, Hong, J H, Kizer, J S, Unsworth, C D, Kanamatsu, T

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Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels by Palkovits, M, Saavedra, J M, Jacoboqitz, D M, Kizer, J S, Záborszky, L, Brownstein, M J

“…Concentrations of serotonin and tryptophan hydroxylase activity in individual hypothalamic and limbic nuclei, as well as cortical regions, were measured by…”
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