Search Results - "Kiyosawa, N"

Comprehensive Evaluation of (+)-Usnic Acid–induced Cardiotoxicity in Rats by Sequential Cross-omics Analysis by Yokouchi, Y., Imaoka, M., Niino, N., Kiyosawa, N., Kai, K.

“…Two-week administration of (+)-usnic acid (UA) induces mitochondrial swelling of cardiomyocytes, and toxicogenomic analysis of the heart revealed upregulation…”
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A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats by Uehara, Takeki, Hirode, Mitsuhiro, Ono, Atsushi, Kiyosawa, Naoki, Omura, Ko, Shimizu, Toshinobu, Mizukawa, Yumiko, Miyagishima, Toshikazu, Nagao, Taku, Urushidani, Tetsuro

“…Abstract For assessing carcinogenicity in animals, it is difficult and costly, an alternative strategy has been desired. We explored the possibility of…”
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Pharmacokinetics and circulating Microrna profiles of extended release Hydromorphone in healthy subjects by To yama, K, Kiyosawa, N, Ishizuka, H, Sambe, T, Kobayashi, S, Uchida, N

“…Background Hydromorphone is a semisynthetic opioid analgesic which has been used extensively as an effective alternative to morphine for the relief of acute…”
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PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons by Kim, S., Kiyosawa, N., Burgoon, L.D., Chang, C.C., Zacharewski, T.R.

“…•PPARα responses were examined in C57BL/6 mice, HepG2 cells and HL1-1 adult stem cells.•This is the first report of PPARα mediated response in human liver stem…”
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Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans by Uehara, T, Kiyosawa, N, Shimizu, T, Omura, K, Hirode, M, Imazawa, T, Mizukawa, Y, Ono, A, Miyagishima, T, Nagao, T, Urushidani, T

“…One expected result from toxicogenomics technology is to overcome the barrier because of species-specific differences in prediction of clinical toxicity using…”
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Scoring multiple toxicological endpoints using a toxicogenomic database by Kiyosawa, Naoki, Ando, Yosuke, Watanabe, Kyoko, Niino, Noriyo, Manabe, Sunao, Yamoto, Takashi

“…As information regarding microarray data sets and toxicogenomic biomarkers grows rapidly, the process of analyzing data and interpreting the results is…”
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Activation of naturally occurring lecithin:Cholesterol acyltransferase mutants by a novel activator compound by Turri, M., Pavanello, C., Ossoli, A., Strazzella, A., Simonelli, S., Laurenzi, T., Kono, K., Yamada, K., Kiyosawa, N., Eberini, I., Calabresi, L.

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Pharbitis class-1 knotted-like homeobox gene, PKn3, shares similar characteristics to those of class-2 knotted-like genes by KOBAYASHI, A, KIYOSAWA, N, SUZUKI, Y, MUROFUSHI, N, YAMAGUCHI, I

“…Three novel homeobox genes, PKn1-3 (Pharbitis knotted-like), were isolated from Japanese morning glory (Pharbitis nil Chois, strain Violet). A sequence…”
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Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition) by Ayusawa, Mamoru, Sonobe, Tomoyoshi, Uemura, Shigeru, Ogawa, Shunnichi, Nakamura, Yoshikazu, Kiyosawa, Nobuyuki, Ishii, Masahiro, Harada, Kensuke

“…Diagnostic guidelines for Kawasaki Disease was revised to meet the present situation in 2002. This issue intends to explain new guidelines and their…”
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Practical application of toxicogenomics for profiling toxicant-induced biological perturbations by Kiyosawa, Naoki, Manabe, Sunao, Yamoto, Takashi, Sanbuissho, Atsushi

“…A systems-level understanding of molecular perturbations is crucial for evaluating chemical-induced toxicity risks appropriately, and for this purpose…”
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Aneurysms of the coronary arteries in Kawasaki disease. An angiographic study of 30 cases by Onouchi, Z, Shimazu, S, Kiyosawa, N, Takamatsu, T, Hamaoka, K

“…Thirty patients with coronary aneurysms associated with Kawasaki disease underwent coronary arteriography. Of 53 aneurysms, five were saccular, 24…”
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Morphological and microarray analysis of T-2 toxin-induced rat fetal brain lesion by Sehata, Shinya, Kiyosawa, Naoki, Makino, Toshihiko, Atsumi, Fusako, Ito, Kazumi, Yamoto, Takashi, Teranishi, Munehiro, Baba, Yasuko, Uetsuka, Koji, Nakayama, Hiroyuki, Doi, Kunio

“…To examine morphological and gene expression changes induced by T-2 toxin in the fetal brain in detail, pregnant rats on day 13 of gestation were treated…”
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Asymptomatic myocardial infarction in Kawasaki disease: long-term prognosis by Shiraishi, I, Onouchi, Z, Hayano, T, Hamaoka, K, Kiyosawa, N

“…Eight patients with Kawasaki disease who had sustained asymptomatic myocardial infarction 8-15 years ago (mean, 13.1 years) were reexamined by various…”
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Molecular mechanism investigation of cycloheximide-induced hepatocyte apoptosis in rat livers by morphological and microarray analysis by Ito, Kazumi, Kiyosawa, Naoki, Kumagai, Kazuyoshi, Manabe, Sunao, Matsunuma, Naochika, Yamoto, Takashi

“…Male F344 rats were intravenously treated with 6 mg/kg cycloheximide (CHX), and microarray analysis was conducted on their livers 1, 2 and 6 h after the CHX…”
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Microarray analysis of T-2 toxin-induced liver, placenta and fetal liver lesions in pregnant rats by Sehata, Shinya, Kiyosawa, Naoki, Atsumi, Fusako, Ito, Kazumi, Yamoto, Takashi, Teranishi, Munehiro, Uetsuka, Koji, Nakayama, Hiroyuki, Doi, Kunio

“…Pregnant rats on day 13 of gestation were treated orally with 2 mg/kg of T-2 toxin and sacrificed at 1, 3, 6, 9 and 12 h after the treatment (HAT)…”
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A case of video-assisted thoracoscopic surgery for patent ductus arteriosus under transesophageal echocardiography by Taniyasu, N, Hiramatsu, T, Koh, E, Ikawa, O, Takenaka, A, Tokuda, H, Yokoji, K, Kiyosawa, N

“…A six-year-old boy with patent ductus arteriosus was successfully treated by thoracoscopic surgery under transesophageal echocardiography, by which…”
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Long-Term Changes in Coronary Artery Aneurysms in Patients With Kawasaki Disease: Comparison of Therapeutic Regimens by Onouchi, Zenshiro, Hamaoka, Kenji, Sakata, Koichi, Ozawa, Seiichiro, Shiraishi, Isao, Itoi, Toshiki, Kiyosawa, Nobuyuki

“…Background There are few studies of the therapeutic regimens for the prevention of stenotic transformation of aneurysms in Kawasaki disease (KD). The aim of…”
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Influence of Kupffer cell inactivation on cycloheximide-induced hepatic injury by Kumagai, Kazuyoshi, Kiyosawa, Naoki, Ito, Kazumi, Yamoto, Takashi, Teranishi, Munehiro, Nakayama, Hiroyuki, Manabe, Sunao

“…Abstract In our previous study, we found that cycloheximide (CHX) induces hepatocellular necrosis as well as hepatocellular apoptosis. This article evaluates…”
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Evaluation of glutathione deficiency in rat livers by microarray analysis by Kiyosawa, Naoki, Ito, Kazumi, Sakuma, Kyoko, Niino, Noriyo, Kanbori, Miyuki, Yamoto, Takashi, Manabe, Sunao, Matsunuma, Naochika

“…Hepatic glutathione content was measured and gene expression data were obtained using an Affymetrix RG U34 array after treatment with tap water containing 20…”
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Microarray analysis on Phase II drug metabolizing enzymes expression in pregnant rats after treatment with pregnenolone-16α-carbonitrile or phenobarbital by Ejiri, Noriko, Katayama, Kei-ichi, Kiyosawa, Naoki, Baba, Yasuko, Doi, Kunio

“…We previously reported the expression profiles of 9 cytochrome P450 isozymes (CYPs) proteins and those of 40 CYPs genes in pregnant rat's liver, placenta and…”
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