Search Results - "Kiyama, Tomomi"

Augmentation of Lipopolysaccharide-Induced Production of IL-1α and IL-1β in Mice Given Intravenous Zoledronate (a Nitrogen-Containing Bisphosphonate) and Its Prevention by Clodronate (a Non-nitrogen-containing Bisphosphonate) by Suzuki, Hikari, Bando, Kanan, Tada, Hiroyuki, Kiyama, Tomomi, Oizumi, Takefumi, Funayama, Hiromi, Sugawara, Shunji, Takahashi, Tetsu, Endo, Yasuo

“…Bisphosphonates (BPs) bind strongly to bone and exhibit long-acting anti-bone-resorptive effects. Among BPs, nitrogen-containing BPs (N-BPs) have far stronger…”
Get full text

Phosphonocarboxylates Can Protect Mice against the Inflammatory and Necrotic Side Effects of Nitrogen-Containing Bisphosphonates by Inhibiting Their Entry into Cells via Phosphate Transporters by Kiyama, Tomomi, Tsuchiya, Masahiro, Okada, Satoru, Oizumi, Takefumi, Yamaguchi, Kouji, Sasaki, Keiichi, Sugawara, Shunji, Endo, Yasuo

“…Bisphosphonates (BPs) are used against diseases involving increased bone-resorption. Among BPs, nitrogen-containing BPs (N-BPs) have much stronger…”
Get full text

Inhibition of Phosphate Transporters Ameliorates the Inflammatory and Necrotic Side Effects of the Nitrogen-Containing Bisphosphonate Zoledronate in Mice by Okada, Satoru, Kiyama, Tomomi, Sato, Eri, Tanaka, Yukinori, Oizumi, Takefumi, Kuroishi, Toshinobu, Takahashi, Tetsu, Sasaki, Keiichi, Sugawara, Shunji, Endo, Yasuo

“…Bisphosphonates (BPs) are pyrophosphate analogs. They are widely used against enhanced bone-resorption in various diseases. Nitrogen-containing BPs (N-BPs)…”
Get full text

骨吸収抑制薬bisphosphonatesによる顎骨壊死の機序・予防・治療に関する基礎研究 by 遠藤, 康男, 船山, ひろみ, 山口, 晃史, 門馬, 祐子, 兪, 志前, 鄧, 雪, 大泉, 丈史, 四釜, 洋介, 田中, 志典, 岡田, 諭, 金, 始瑛, 木山, 朋美, 坂東, 加南, 島, 和弘, 鈴木, 飛佳理, 高橋, 哲

“…「1. はじめに」ピロリン酸の研究から始まったbisphosphonates(BPs)(以前はdiphosphonatesと呼称)の研究は, 現在, 骨転移性がん(乳がん, 前立腺がん, 肺がんなど)・多発性骨髄腫・骨粗鬆症・骨形成不全など, 骨吸収亢進を伴う広い疾患へのBPsの応用に至っている…”
Get full text

Inflammatory and Necrotic Effects of Minodronate, a Nitrogen-Containing Bisphosphonate, in Mice by Kiyama, Tomomi, Okada, Satoru, Tanaka, Yukinori, Kim, Siyoung, Bando, Kanan, Hasegawa, Masakazu, Yamaguchi, Kouji, Takano-Yamamoto, Teruko, Sasaki, Keiichi, Sugawara, Shunji, Endo, Yasuo

“…Diseases involving enhanced bone-resorption (e.g., osteoporosis) are widely treated with bisphosphonates (BPs). BPs are of two types: the nitrogen-containing…”
Get full text

Interleukin-6 Maintains Glucose Homeostasis to Support Strenuous Masseter Muscle Activity in Mice by Tsuchiya, Masahiro, Kiyama, Tomomi, Tsuchiya, Shinobu, Takano, Hirohisa, Nemoto, Eiji, Sasaki, Keiichi, Watanabe, Makoto, Sugawara, Shunji, Endo, Yasuo

“…The cytokine interleukin-6 (IL-6) is released from working skeletal muscles and reportedly plays key roles in their glucose homeostasis. However, it is unclear…”
Get full text

Phosphonocarboxylates Can Protect Mice against the Inflammatory and Necrotic Side Effects of Nitrogen-Containing Bisphosphonates by Inhibiting Their Entry into Cells via Phosphate Transporters by Tomomi Kiyamaa, b, Masahiro Tsuchiyac, Satoru Okadaa, Takefumi Oizumia, Kouji Yamaguchia, Keiichi Sasakib, Shunji Sugawaraa, Yasuo Endoa

“…Bisphosphonates (BPs) are used against diseases involving increased bone-resorption. Among BPs, nitrogen-containing BPs (N-BPs) have much stronger…”
Get full text

Possible pathogenic engagement of soluble Semaphorin 4D produced by γδT cells in medication-related osteonecrosis of the jaw (MRONJ) by Movila, Alexandru, Mawardi, Hani, Nishimura, Kazuaki, Kiyama, Tomomi, Egashira, Kenji, Kim, Jae-Young, Villa, Alessandro, Sasaki, Hajime, Woo, Sook-Bin, Kawai, Toshihisa

“…Prior consensus held that medication-related osteonecrosis of the jaw (MRONJ) lesion was composed of necrotic bone; however, more recent studies have…”
Get full text

Possible pathogenic engagement of soluble Semaphorin 4D produced by gamma delta T cells in medication-related osteonecrosis of the jaw (MRONJ) by Movila, Alexandru, Mawardi, Hani, Nishimura, Kazuaki, Kiyama, Tomomi, Egashira, Kenji, Kim, Jae-Young, Villa, Alessandro, Sasaki, Hajime, Woo, Sook-Bin, Kawai, Toshihisa

“…Prior consensus held that medication-related osteonecrosis of the jaw (MRONJ) lesion was composed of necrotic bone; however, more recent studies have…”
Get full text

Basic Studies on the Mechanism, Prevention, and Treatment of Osteonecrosis of the Jaw Induced by Bisphosphonates by Endo, Yasuo, Funayama, Hiromi, Yamaguchi, Kouji, Monma, Yuko, Yu, Zhiqian, Deng, Xue, Oizumi, Takefumi, Shikama, Yosuke, Tanaka, Yukinori, Okada, Satoshi, Kim, Siyoung, Kiyama, Tomomi, Bando, Kanan, Shima, Kazuhiro, Suzuki, Hikari, Takahashi, Tetsu

“…Since the first report in 2003, bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been increasing, without effective clinical strategies…”
Get full text

Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project by Tsuboi, Akito, Matsui, Hiroyuki, Shiraishi, Naru, Murakami, Takahisa, Otsuki, Akihito, Kawashima, Junko, Kiyama, Tomomi, Tamahara, Toru, Goto, Maki, Koyama, Shihoko, Sugawara, Junichi, Kodama, Eiichi N., Metoki, Hirohito, Hozawa, Atsushi, Kuriyama, Shinichi, Tomita, Hiroaki, Kikuya, Masahiro, Minegishi, Naoko, Suzuki, Kichiya, Koshiba, Seizo, Tamiya, Gen, Fuse, Nobuo, Aoki, Yuichi, Takai-Igarashi, Takako, Ogishima, Soichi, Nakamura, Tomohiro, Sakurai-Yageta, Mika, Nagami, Fuji, Kinoshita, Kengo, Kure, Shigeo, Shimizu, Ritsuko, Sasaki, Keiichi, Yamamoto, Masayuki

“…In order to assess the long-term impact of the Great East Japan Earthquake on the oral health of disaster victims and to evaluate gene-environmental…”
Get full text