Search Results - "Kiwada, H"

The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs by Nagayasu, A, Uchiyama, K, Kiwada, H

“…The size of liposomes has been shown to be an important factor in the efficient delivery of an antitumor agent to a tumor. In this paper, the effects of the…”
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Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production by Hashimoto, Y, Uehara, Y, Abu Lila, A S, Ishida, T, Kiwada, H

“…Cationic liposome represents a promising alternative to viral vectors for the delivery of therapeutic genes. For in vivo use, surface modification of the…”
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230 An Entirely Novel Nanoparticle Carrying a Bioactive shRNA Molecule (DFP-10825) Could Be Clinically Effective Against the High Risk Patients with Mesothelioma Relapsed or Refractory After Treatment with Pemetrexed Based Chemotherapy by Ishida, T, Lila, A.S. Abu, Huang, C, Wada, H, Fukushima, M, Kiwada, H

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Quantitative analysis of correlation between number of nuclear plasmids and gene expression activity after transfection with cationic liposomes by TACHIBANA, Rieko, HARASHIMA, Hideyoshi, IDE, Naoko, UKITSU, Sachiko, OHTA, Yasuko, SUZUKI, Norio, KIKUCHI, Hiroshi, SHINOHARA, Yasuo, KIWADA, Hiroshi

“…A quantitative understanding of the intracellular trafficking of plasmids delivered by nonviral vectors is essential for optimizing vector functions to…”
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Liposomal targeting and drug delivery: kinetic consideration by Harashima, H., Kiwada, H.

“…As drug carriers, liposomes have great potential in that selective targeting and release rate control of drugs can be performed by appropriate modifications to…”
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Identification of proteins mediating clearance of liposomes using a liver perfusion system by Harashima, H, Matsuo, H, Kiwada, H

“…The objective of this paper is to identify the principal blood components governing the fate of liposomes in blood circulation. Information based on an…”
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Pharmacokinetic/pharmacodynamic modeling of antitumor agents encapsulated into liposomes by Harashima, H., Tsuchihashi, M., Iida, S., Doi, H., Kiwada, H.

“…Pharmacokinetic/pharmacodynamic (PK/PD) modeling of antitumor agents has been developed for doxorubicin (DOX) in order to predict the optimum conditions for a…”
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Repopulation of murine Kupffer cells after intravenous administration of liposome-encapsulated dichloromethylene diphosphonate by Yamamoto, T, Naito, M, Moriyama, H, Umezu, H, Matsuo, H, Kiwada, H, Arakawa, M

“…Kupffer cells were selectively eliminated in mice by the intravenous administration of liposome-entrapped dichloromethylene diphosphonate. At 5 days, small…”
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Synergistic effect between size and cholesterol content in the enhanced hepatic uptake clearance of liposomes through complement activation in rats by HARASHIMA, H, HUONG, T. M, ISHIDA, T, MANABE, Y, MATSUO, H, KIWADA, H

“…The effect of liposome size and cholesterol (CH) content on the pharmacokinetics of liposomes was investigated in rats. The pharmacokinetics of liposomes was…”
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Size dependent liposome degradation in blood: in vivo/in vitro correlation by kinetic modeling by Harashima, H, Hiraiwa, T, Ochi, Y, Kiwada, H

“…The degradation of liposomes in blood circulation is important in regulating the releasing rate of encapsulated compounds. In this study, the effect of…”
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Species difference in the disposition of liposomes among mice, rats, and rabbits : Allometric relationship and species dependent hepatic uptake mechanism by HARASHIMA, H, KOMATSU, S, KOJIMA, S, YANAGI, C, MORIOKA, Y, NAITO, M, KIWADA, H

“…The species difference in the pharmacokinetics of liposomes was investigated in mice, rats and rabbits. Liposomes were intravenously injected at doses of 1, 10…”
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Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes by Ishida, Tatsuhiro, Ichihara, Masako, Wang, XinYu, Yamamoto, Kenji, Kimura, Junji, Majima, Eiji, Kiwada, Hiroshi

“…Steric stabilization of the surface of liposomes by a PEG conjugated lipid results in reduced recognition of the liposomes by the cells of the mononuclear…”
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Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: Effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes by Ishida, Tatsuhiro, Harada, Masae, Wang, Xin Yu, Ichihara, Masako, Irimura, Kenji, Kiwada, Hiroshi

“…We recently reported that a second dose of polyethylene glycol (PEG) (M.W. 2000)-modified liposomes (mPEG 2000-liposomes) is rapidly cleared from the blood and…”
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Species Difference in Correlation between in Vivo/in Vitro Liposome-Complement Interactions by HUONG, Tran Minh, ISHIDA, Tatsuhiro, HARASHIMA, Hideyoshi, KIWADA, Hiroshi

“…The objective of this study was to investigate the correlation between in vitro and in vivo liposome-complement interactions. Third component of the complement…”
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Accelerated clearance of PEGylated liposomes in rats after repeated injections by Ishida, Tatsuhiro, Maeda, Ryuhei, Ichihara, Masako, Irimura, Kenji, Kiwada, Hiroshi

“…Polyethylene glycol-modified liposomes (PEGylated liposomes) represent promising carrier systems for therapeutic agents. Herein, we report on a study of the…”
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Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood by Ishida, Tatsuhiro, Okada, Yurie, Kobayashi, Tomotaka, Kiwada, Hiroshi

“…We have reported that targeted, pH-sensitive sterically stabilized liposomes are able to increase the cytotoxicity of DXR in vitro against B lymphoma cells,…”
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Liposome clearance by Ishida, Tatsuhiro, Harashima, Hideyoshi, Kiwada, Hiroshi

“…The clearance rate of liposomal drugs from the circulation is determined by the rate and extent of both drug release and uptake of liposomes by cells of the…”
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Solubilization by Triton X-100 makes possible complete recovery of lipids from liposomes in enzymatic assay by Nagayasu, A, Shimooka, T, Kiwada, H

“…We have developed an accurate and sensitive method for enzymatically determining phosphatidylcholine (PC) and cholesterol (CHOL) in liposomes. Solubilizing…”
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Cationic liposome-mediated gene delivery: Biophysical study and mechanism of internalization by Radwan Almofti, Mohamad, Harashima, Hideyoshi, Shinohara, Yasuo, Almofti, Ammar, Baba, Yoshinobu, Kiwada, Hiroshi

“…To identify factors affecting cationic liposome-mediated gene delivery efficiency, we studied the relationship between the biophysical characteristics of…”
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Accelerated clearance of a second injection of PEGylated liposomes in mice by Ishida, Tatsuhiro, Masuda, Kaori, Ichikawa, Takako, Ichihara, Masako, Irimura, Kenji, Kiwada, Hiroshi

“…We recently reported that the firstly injected PEGylated liposomes dramatically affected the rate of blood clearance of secondly injected PEGylated liposomes…”
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