Search Results - "Kiuchi, Yoichi"

QT PRODACT: A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles by Hayashi, Seiji, Kii, Yoshihide, Tabo, Mitsuyasu, Fukuda, Hitoshi, Itoh, Tetsuji, Shimosato, Takashi, Amano, Hideto, Saito, Mamoru, Morimoto, Hajime, Yamada, Kiyoshi, Kanda, Atsuhiro, Ishitsuka, Toshimasa, Yamazaki, Takanobu, Kiuchi, Yoichi, Taniguchi, Shinya, Mori, Tatsuya, Shimizu, Shigekazu, Tsurubuchi, Yuji, Yasuda, Shun-ichi, Kitani, Shin-ichi, Shimada, Chiaki, Kobayashi, Kazuo, Komeno, Masaharu, Kasai, Chieko, Hombo, Toshiyasu, Yamamoto, Keiji

“…To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on…”
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QT PRODACT: Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles by Kii, Yoshihide, Hayashi, Seiji, Tabo, Mitsuyasu, Shimosato, Takashi, Fukuda, Hitoshi, Itoh, Tetsuji, Amano, Hideto, Saito, Mamoru, Morimoto, Hajime, Yamada, Kiyoshi, Kanda, Atsuhiro, Ishitsuka, Toshimasa, Yamazaki, Takanobu, Kiuchi, Yoichi, Taniguchi, Shinya, Mori, Tatsuya, Shimizu, Shigekazu, Tsurubuchi, Yuji, Yasuda, Shun-ichi, Kitani, Shin-ichi, Shimada, Chiaki, Kobayashi, Kazuo, Komeno, Masaharu, Kasai, Chieko, Hombo, Toshiyasu, Yamamoto, Keiji

“…Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit…”
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Effect of GK-128 [2-[(2-methylimidazol-1-yl)methyl]-benzo[f]thiochromen-1-one monohydrochloride hemihydrate], a selective 5-hydroxytryptamine3 receptor antagonist, on colonic function in rats by Ito, C, Isobe, Y, Kawamura, R, Kiuchi, Y, Tsuchida, K, Higuchi, S

“…We investigated the effects of various selective 5-hydroxytryptamine (5-HT)3 receptor antagonists, including GK-128…”
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Type IV collagen prevents amyloid β-protein fibril formation by Kiuchi, Yoichi, Isobe, Yoshihiko, Fukushima, Kiyomi

“…The potential of targeting through molecular therapeutics the underlying amyloid β-protein (Aβ) fibrillogenesis causing the initiation and progression of…”
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β-amyloid induces caspase-dependent early neurotoxic change in PC12 cells: correlation with H2O2 neurotoxicity by SAITO, Takashi, KIJIMA, Haruko, KIUCHI, Yoichi, ISOBE, Yoshihiko, FUKUSHIMA, Kiyomi

“…We examined neurotoxic effects of Abeta(25-35), an active fragment of beta-amyloid (Abeta), and compared the effect with H2O2 neurotoxicity in PC12 cells…”
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Disassembly of amyloid β-protein fibril by basement membrane components by Kiuchi, Yoichi, Isobe, Yoshihiko, Fukushima, Kiyomi, Kimura, Masaaki

“…Amyloid β-protein (Aβ) fibril in senile plaque may be related to the pathogenesis of Alzheimer's disease (AD). Basement membrane (BM) components are associated…”
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Effect of pibutidine hydrochloride on nitric oxide production in rat gastric mucosa by Kiuchi, Yoichi, Isobe, Yoshihiko, Kijima, Haruko, Higuchi, Shohei, Fukushima, Kiyomi

“…Our previous study have already demonstrated a gastric mucosal protective action of pibutidine hydrochloride (pibutidine), a novel histamine H_2 receptor…”
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Entactin-induced inhibition of human amyloid β-protein fibril formation in vitro by Kiuchi, Yoichi, Isobe, Yoshihiko, Fukushima, Kiyomi

“…Amyloid β-protein (Aβ) fibril in senile plaques may possibly be related to the pathogenesis of Alzheimer's disease (AD). Basement membrane (BM) components are…”
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EFFECT OF THE NEW ANTI-ULCER DRUG SU-840 ON PROSTAGLANDIN METABOLISM IN RAT GASTRIC MUCOSA by Kiuchi, Yoichi, Isobe, Yoshihiko, Kijima, Haniko, Muramatsu, Makoto, Otomo, Susumu

“…The effects of a new anti-ulcer agent (SU-840), an inclusion-complex of 4-t-butyl-2' -carboxymethoxy-4' -(3-methyl-2-butenyloxy) chalcone (SU-740), on…”
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Anti-ulcer and anti-secretory effects of SU-840, a novel anti-ulcer agent by Isobe, Yoshihiko, Kiuchi, Yoichi, Kijita, Haruko, Muramatsu, Makoto, Otoao, Susuau

“…Anti-ulcer and anti-secretory effects of an inclusion-complex of 4-t-butyl-2'-carboxy-methoxy-4'-(3-methyl-2-butenyloxy) chalcone (SU-740), which inhibits…”
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β-amyloid induces caspase-dependent early neurotoxic change in PC12 cells: correlation with H 2O 2 neurotoxicity by Saito, Takashi, Kijima, Haruko, Kiuchi, Yoichi, Isobe, Yoshihiko, Fukushima, Kiyomi

“…We examined neurotoxic effects of Aβ(25–35), an active fragment of β-amyloid (Aβ), and compared the effect with H 2O 2 neurotoxicity in PC12 cells. Aβ(25–35)…”
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The anti-emetic activity of GK-128 in Suncus murinus by Ito, Chika, Isobe, Yoshihiko, Kijima, Haruko, Kiuchi, Yoichi, Ohtsuki, Hiroshi, Kawamura, Reiko, Tsuchida, Katsuharu, Higuchi, Shohei

“…In Suncus murinus, various emetic responses and the anti-emetic activity of a new 5-hydroxytryptamine 3 (5-HT 3) receptor antagonist, GK-128…”
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Protective effect of pibutidine hydrochloride, a novel histamine H2-receptor antagonist, on the gastric mucosal lesions in rats by Kiuchi, Yoichi, Isobe, Yoshihiko, Kijima, Haruko, Saito, Takashi, Higuchi, Shohei

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Mechanism of interaction of propylbenzilylcholine mustard with muscarinic cholinoceptor in guinea pig taenia caecum by Kiuchi, Yoichi, Hisayama, Tetsuhiro, Takayanagi, Issei

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P-365 - Anti-ulcer and anti-secretory effects of SU-840, a novel anti-ulcer agent by Isobe, Yoshihiko, Kiuchi, Yoichi, Kijita, Haruko, Muramatsu, Makoto, Otoao, Susuau

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P-364 - effect of the new ANTI-ULCER drug SU-840 ON PROSTAGLANDIN METABOLISM IN RAT GASTRIC MUCOSA by Kiuchi, Yoichi, Isobe, Yoshihiko, Kijima, Haniko, Muramatsu, Makoto, Otomo, Susumu

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The interaction of a new H2-receptor antagonist, pubutidine hydrochloride (IT-066), with the canine cloned H2-receptor expressed Hepa cells by Isobe, Yoshihiko, Kaku, Shinsuke, Kiuchi, Yoichi, Tanaka, Makoto, Muramatsu, Makoto, Higuchi, Shohei

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P-561 - Maintenance of synthetic activity of gastric mucosal macromolecular glycoprotein by a new H2-receptor antagonist, IT-066, in cold-stress plus indomethacin treated rats by Kiuchi, Yoichi, Isobe, Yoshihiko, Muramatsu, Makoto, Otomo, Susumu

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Maintenance of synthetic activity of gastric mucosal macromolecular glycoprotein by a new H2-receptor antagonist, IT-066, in cold-stress plus indomethacin treated rats by Kiuchi, Yoichi, Isobe, Yoshihiko, Muramatsu, Makoto, Otomo, Susumu

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P-194 - Differences between 5-HT3 receptor antagonists in regulation of colonic function by Ito, Chika, Kawamura, Reiko, Kiuchi, Yoichi, Isobe, Yoshihiko, Tsuchida, Katsuharu, Higuchi, Shohei

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