Search Results - "Kitt, Michael"

The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study by Morice, Alyn H, Kitt, Michael M, Ford, Anthony P, Tershakovec, Andrew M, Wu, Wen-Chi, Brindle, Kayleigh, Thompson, Rachel, Thackray-Nocera, Susannah, Wright, Caroline

“…We evaluated the effect of gefapixant on cough reflex sensitivity to evoked tussive challenge.In this phase 2, double-blind, two-period study, patients with…”
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Gefapixant in two randomised dose-escalation studies in chronic cough by Smith, Jaclyn A, Kitt, Michael M, Butera, Peter, Smith, Steven A, Li, Yuping, Xu, Zhi Jin, Holt, Kimberley, Sen, Shilpi, Sher, Mandel R, Ford, Anthony P

“…Gefapixant has previously demonstrated efficacy in the treatment of refractory chronic cough at a high daily dose. The current investigations explore efficacy…”
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The discovery and development of gefapixant by Ford, Anthony P., Dillon, Michael P., Kitt, Michael M., Gever, Joel R.

“…Gefapixant is the approved generic name for a compound also known as MK-7264, and prior to that AF-219 and RO-4926219. It is the first-in-class clinically…”
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Telavancin Versus Vancomycin for the Treatment of Complicated Skin and Skin-Structure Infections Caused by Gram-Positive Organisms by Stryjewski, Martin E., Graham, Donald R., Wilson, Samuel E., O'Riordan, William, Young, David, Lentnek, Arnold, Ross, Douglas P., Fowler, Vance G., Hopkins, Alan, Friedland, H. David, Barriere, Steven L., Kitt, Michael M., Corey, G. Ralph

“…Background. Telavancin is an investigational, rapidly bactericidal lipoglycopeptide with a multifunctional mechanism of action. Methods. We conducted 2…”
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The design and rationale for the Acute Medically Ill Venous Thromboembolism Prevention with Extended Duration Betrixaban (APEX) study by Cohen, Alexander T., MD, Harrington, Robert, MD, Goldhaber, Samuel Z., MD, Hull, Russell, MD, Gibson, C. Michael, MD, Hernandez, Adrian F., MD, MHS, Kitt, Michael M., MD, Lorenz, Todd J., MD

“…Randomized clinical trials have identified a population of acute medically ill patients who remain at risk for venous thromboembolism (VTE) beyond the standard…”
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Single‐ and Multiple‐Dose Pharmacokinetics of Gefapixant (MK‐7264), a P2X3 Receptor Antagonist, in Healthy Adults by Nussbaum, Jesse C., Hussain, Azher, Butera, Peter, Ford, Anthony P., Kitt, Michael M., O'Neill, Edward A., Smith, Steven, Vargas, Gabriel, O'Reilly, Terry, Wynne, Chris, Stoch, S. Aubrey, Iwamoto, Marian

“…Gefapixant (MK‐7264, RO4926219, AF‐219) is a first‐in‐class P2X3 antagonists being developed to treat refractory or unexplained chronic cough. The initial…”
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A randomized Phase 2 trial of telavancin versus standard therapy in patients with uncomplicated Staphylococcus aureus bacteremia: the ASSURE study by Stryjewski, Martin E, Lentnek, Arnold, O'Riordan, William, Pullman, John, Tambyah, Paul Anantharajah, Miró, Jose M, Fowler, Jr, Vance G, Barriere, Steven L, Kitt, Michael M, Corey, G Ralph

“…Staphylococcus aureus bacteremia is a common infection associated with significant morbidity and mortality. Telavancin is a bactericidal lipoglycopeptide…”
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Treatment of Persistent Cough in Subjects with Idiopathic Pulmonary Fibrosis (IPF) with Gefapixant, a P2X3 Antagonist, in a Randomized, Placebo-Controlled Clinical Trial by Martinez, Fernando J., Afzal, Amna Sadaf, Smith, Jaclyn A., Ford, Anthony P., Li, Jerry Jing, Li, Yuping, Kitt, Michael M.

“…Introduction Chronic cough is a highly problematic symptom for patients with idiopathic pulmonary fibrosis (IPF); limited therapeutic options are available. We…”
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Treatment with the P2X3-Receptor Antagonist Gefapixant for Acute Cough in Induced Viral Upper Respiratory Tract Infection: A Phase 2a, Randomized, Placebo-Controlled Trial by Smith, Jaclyn A., Kitt, Michael M., Bell, Alan, Noulin, Nicolas, Tzontcheva, Anjela, Seng, Megan McGratty, Lu, Susan

“…Introduction Available therapies for acute cough, a condition frequently caused by a viral upper respiratory tract infection (URTI), have shown limited…”
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Author response: The human cough reflex has separate, distinct pathways by Morice, Alyn H, Kitt, Michael M, Ford, Anthony P, Tershakovec, Andrew M, Wu, Wen-Chi, Brindle, Kayleigh, Thompson, Rachel, Thackray-Nocera, Susannah, Wright, Caroline

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Telavancin versus Standard Therapy for Treatment of Complicated Skin and Skin Structure Infections Caused by Gram-Positive Bacteria: FAST 2 Study by STRYJEWSKI, Martin E, CHU, Vivian H, KITT, Michael M, COREY, G. Ralph, O'RIORDAN, William D, WARREN, Brian L, DUNBAR, Lala M, YOUNG, David M, VALLEE, Marc, FOWLER, Vance G, MORGANROTH, Joel, BARRIERE, Steven L

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Intrapulmonary Distribution of Intravenous Telavancin in Healthy Subjects and Effect of Pulmonary Surfactant on In Vitro Activities of Telavancin and Other Antibiotics by GOTFRIED, Mark H, SHAW, Jeng-Pyng, BENTON, Bret M, KRAUSE, Kevin M, GOLDBERG, Michael R, KITT, Michael M, BARRIERE, Steven L

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Telavancin Versus Standard Therapy for Treatment of Complicated Skin and Soft-Tissue Infections Due to Gram-Positive Bacteria by Stryjewski, Martin E., O'Riordan, William D., Lau, William K., Pien, Francis D., Dunbar, Lala M., Vallee, Marc, Fowler, Vance G., Chu, Vivian H., Spencer, Elizabeth, Barriere, Steven L., Kitt, Michael M., Cabell, Christopher H., Corey, G. Ralph

“…Background Telavancin, a novel lipoglycopeptide, exerts concentration-dependent, rapid bactericidal activity on account of its multiple mechanisms of action…”
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Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa by Siegal, Deborah, Lu, Genmin, Leeds, Janet M., Karbarz, Mark, Castillo, Janice, Mathur, Vandana, Hutchaleelaha, Athiwat, Sinha, Uma, Kitt, Michael, McClure, Matt, Hollenbach, Stanley J., Curnutte, John T., Conley, Pamela B., Crowther, Mark

“…Direct factor Xa (FXa) inhibitors lack a specific reversal agent for emergencies such as major bleeding or urgent surgery. Andexanet alfa, a modified,…”
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Mass Balance and Pharmacokinetics of [14C]Telavancin following Intravenous Administration to Healthy Male Volunteers by SHAW, Jeng-Pyng, CHEONG, Jonathan, GOLDBERG, Michael R, KITT, Michael M

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Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections associated with surgical procedures by Wilson, Samuel E., M.D, O'Riordan, William, M.D, Hopkins, Alan, Ph.D, Friedland, H. David, M.D, Barriere, Steven L., Pharm.D, Kitt, Michael M., M.D

“…Abstract Background We compared telavancin with vancomycin for the treatment of complicated skin and skin-structure infections (cSSSI) caused by Gram-positive…”
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Multiple-dose pharmacokinetics of intravenous telavancin in healthy male and female subjects by Wong, Shekman L., Barriere, Steven L., Kitt, Michael M., Goldberg, Michael R.

“…Objectives The aim of this study was to assess the steady-state pharmacokinetic parameters of telavancin, an investigational bactericidal lipoglycopeptide,…”
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Abstract 10: Randomized, Double-Blind, Placebo-Controlled Single Ascending Dose Pharmacokinetic and Pharmacodynamic Study of PRT064445, a Universal Antidote for Factor Xa Inhibitors by Crowther, Mark, Kitt, Michael, McClure, Matthew, Sinha, Uma, Lu, Genmin, Karbarz, Mark, Hutchaleelaha, Athiwat, Barron, Lee, Mathur, Vandana, Curnutte, John

“…Abstract only…”
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Single-Dose Pharmacokinetics and Tolerability of Telavancin in Elderly Men and Women by Goldberg, Michael R., Wong, Shekman L., Shaw, Jeng-Pyng, Kitt, Michael M., Barriere, Steven L.

“…Study Objective. To assess the safety and tolerability, and the effect of sex on the pharmacokinetic disposition, of a single intravenous dose of telavancin 10…”
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In vitro activity of telavancin and occurrence of vancomycin heteroresistance in isolates from patients enrolled in phase 3 clinical trials of hospital-acquired pneumonia by Krause, Kevin M, Blais, Johanne, Lewis, Stacey R, Lunde, Christopher S, Barriere, Steven L, Friedland, H. David, Kitt, Michael M, Benton, Bret M

“…Abstract In phase 3 studies of the efficacy of telavancin for the treatment of hospital-acquired pneumonia, 704 Gram-positive and 627 Gram-negative aerobic…”
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