Search Results - "Kitos, Paul A"

Ectoadenylate Kinase and Plasma Membrane ATP Synthase Activities of Human Vascular Endothelial Cells by Quillen, Ellen E., Haslam, Gale C., Samra, Hardeep S., Amani-Taleshi, Darius, Knight, Jeffrey A., Wyatt, Diane E., Bishop, Stephanie C., Colvert, Kim K., Richter, Mark L., Kitos, Paul A.

“…Formation of ATP from ADP on the external surface of vascular endothelial cells has been attributed to plasma membrane ATP synthase, ectoadenylate kinase…”
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Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore by Boger, Dale L, Ishizaki, Takayoshi, Zarrinmayeh, Hamideh, Munk, Stephen A, Kitos, Paul A, Suntornwat, Oranart

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Synthesis of N-(tert-butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) left-hand subunit by Boger, Dale L, Ishizaki, Takayoshi, Kitos, Paul A, Suntornwat, Oranart

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Estimating the number of viable animal cells in multi-well cultures based on their lactate dehydrogenase activities by HASLAM, G, WYATT, D, KITOS, P. A

“…A method is described for estimating the numbers ofanimal cells in multi-well culture by simultaneouslymeasuring the lactate dehydrogenase activity of thetotal…”
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Reversed and Sandwiched Analogs of Duocarmycin SA:  Establishment of the Origin of the Sequence-Selective Alkylation of DNA and New Insights into the Source of Catalysis by Boger, Dale L, Bollinger, Bernd, Hertzog, Donald L, Johnson, Douglas S, Cai, Hui, Mésini, Philippe, Garbaccio, Robert M, Jin, Qing, Kitos, Paul A

“…The synthesis and examination of two unique classes of duocarmycin SA analogs are described which we refer to as reversed and sandwiched analogs. Their…”
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Synthesis, Chemical Properties, and Preliminary Evaluation of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Cyano-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one Alkylation Subunit:  Hammett Quantitation of the Magnitude of Electronic Effects on Functional Reactivity by Boger, Dale L, Han, Nianhe, Tarby, Christine M, Boyce, Christopher W, Cai, Hui, Jin, Qing, Kitos, Paul A

“…The synthesis of 7-cyano-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CCBI), a substituted CBI derivative bearing a C7 cyano group, is described in…”
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Total synthesis and preliminary evaluation of (+)- and ent-(-)-duocarmycin SA by Boger, Dale L, Machiya, Kozo, Hertzog, Donald L, Kitos, Paul A, Holmes, Daniel

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Total synthesis and evaluation of (.+-.)-N-(tert-butoxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunit by Boger, Dale L, Ishizaki, Takayoshi, Wysocki, Ronald J, Munk, Stephen A, Kitos, Paul A, Suntornwat, Oranart

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A Hammett correlation for CC-1065 and duocarmycin analogs: Magnitude of substituent electronic effects on functional reactivity by Boger, Dale L., McKie, Jeffrey A., Han, Nianhe, Tarby, Christine M., Riggs, Haiqiong W., Kitos, Paul A.

“…A quantitative Hammett study of the magnitude of the electronic effects of a C7 substituent on the functional reactivity of N-BOC-CBI ( 5, RH), its impact on…”
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Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors by Boger, Dale L, Kochanny, Monica J, Cai, Hui, Wyatt, Diane, Kitos, Paul A, Warren, M.S, Ramcharan, J, Gooljarsingh, Lata T, Benkovic, Stephen J

“…The synthesis and evaluation of 1– 4 as potential inhibitors of GAR Tfase and AICAR Tfase are detailed…”
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Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones by Boger, Dale L, Yasuda, Masami, Mitscher, Lester A, Drake, Steven D, Kitos, Paul A, Thompson, Sandra Collins

“…The preparation and evaluation of 7-amino-5,8-dioxo-2-(2'-pyridyl)quinoline-6'-carboxylic acid (5a) and…”
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Design, synthesis and evaluation of bouvardin, deoxybouvardin and RA-I-XIV pharmacophore analogs by Boger, D L, Patane, M A, Jin, Q, Kitos, P A

“…The synthesis and in vitro cytotoxic evaluation of a key set of cycloisodityrosine subunit analogs of deoxybouvardin and RA-VII are detailed and constitute a…”
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Key analogs of the tetrapeptide subunit of RA-VII and deoxybouvardin by Boger, Dale L., Zhou, Jiacheng, Winter, Brian, Kitos, Paul A.

“…The synthesis and evaluation of two key analogs 3 and 4 of the potent antitumor antibiotics deoxybouvardin (1) and RA-VII (2) which contain fundamental…”
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Synthesis of N-(tert-butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) left-hand subunit [Erratum to document cited in CA113(23):211667n] by Boger, Dale L, Ishizaki, Takayoshi, Kitos, Paul A, Suntornwat, Oranart

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Synthesis and evaluation of aborted and extended CC-1065 functional analogs: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of key partial structures and definition of an additional functional role of the CC-1065 central and right-hand subunits by Boger, Dale L, Coleman, Robert S, Invergo, Benedict J, Sakya, Subas M, Ishizaki, Takayoshi, Munk, Stephen A, Zarrinmayeh, Hamideh, Kitos, Paul A, Thompson, Sandra Collins

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Histone H2A phosphorylation in animal cells: functional considerations by Prentice, David A, Loechel, Steven C, Kitos, Paul A

“…We have sought to determine the role of histone H2A phosphorylation in chromatin by examining the distribution of the phosphorylated and unphosphorylated forms…”
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Adsorption of polyadenylate and other polynucleotides to unmodified cellulose by Kitos, Paul A, Amos, Harold

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Total synthesis and evaluation of (±)-N-(tert-butyloxycarbonyl)-CBI, (±)-CBI-CDPI1, and (±)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocycloprop[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunit by BOGER, D. L, ISHIZAKI, T, WYSOCKI, R. J, MUNK, S. A, KITOS, P. A, SUNTORNWAT, O

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10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): A potent inhibitor of glycinamide ribonucleotide transformylase by Boger, Dale L., Haynes, Nancy-Ellen, Kitos, Paul A., Warren, Mark S., Ramcharan, Joseph, Marolewski, Ariane E., Benkovic, Stephen J.

“…The synthesis of 10-formyl-5,8,10-trideazafolic acid ( 3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) is reported. The…”
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Identification of Serine Esterases in Tissue Homogenates by Keshavarz-Shokri, Ali, Suntornwat, Oranart, Kitos, Paul A.

“…Serine esterases react with [3H]diisopropylphosphofluoridate ([3H]DFP) to produce radioactive adducts that can be resolved by denaturing slab gel…”
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