Search Results - "Kitos, P A"

Estimating the number of viable animal cells in multi-well cultures based on their lactate dehydrogenase activities by HASLAM, G, WYATT, D, KITOS, P. A

“…A method is described for estimating the numbers ofanimal cells in multi-well culture by simultaneouslymeasuring the lactate dehydrogenase activity of thetotal…”
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Demonstration of a Pronounced Effect of Noncovalent Binding Selectivity on the (+)-CC-1065 DNA Alkylation and Identification of the Pharmacophore of the Alkylation Subunit by Boger, Dale L., Zarrinmayeh, Hamideh, Munk, Stephen A., Kitos, Paul A., Suntornwat, O.

“…Studies on the structural origin of the DNA alkylation selectivity of the antitumor antibiotic (+)-CC-1065 are detailed. The sites of alkylation of…”
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Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophore by Boger, Dale L, Ishizaki, Takayoshi, Zarrinmayeh, Hamideh, Kitos, P. A, Suntornwat, O

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Antibody transport in cultured tumor cell layers by Topp, E.M, Kitos, P.A, Vijaykumar, V, DeSilva, B.S, Hendrickson, T.L

“…This review summarizes our recent in vitro studies of the factors affecting the tumor penetration of immunoconjugates. The studies were designed to probe the…”
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Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones by Boger, Dale L, Yasuda, Masami, Mitscher, Lester A, Drake, Steven D, Kitos, Paul A, Thompson, Sandra Collins

“…The preparation and evaluation of 7-amino-5,8-dioxo-2-(2'-pyridyl)quinoline-6'-carboxylic acid (5a) and…”
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Protease nexin 1 is expressed in the human placenta by White, E A, Baker, J B, McGrogan, M, Kitos, P A

“…Protease nexin 1 (PN1), a serine protease inhibitor that inactivates thrombin, urokinase, and plasmin, is produced abundantly in cultures of human fibroblasts…”
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High Density Culture of Mammalian Cells in a Nonwoven Polyester Matrix by Vijaykumar, V., Kitos, P. A., Topp, E. M.

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Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore by Boger, Dale L, Ishizaki, Takayoshi, Zarrinmayeh, Hamideh, Munk, Stephen A, Kitos, Paul A, Suntornwat, Oranart

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Total synthesis and evaluation of (±)-N-(tert-butyloxycarbonyl)-CBI, (±)-CBI-CDPI1, and (±)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocycloprop[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunit by BOGER, D. L, ISHIZAKI, T, WYSOCKI, R. J, MUNK, S. A, KITOS, P. A, SUNTORNWAT, O

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Perceiving Mitosis in Eukaryotic Cells by Kim, Hae-Young, Dennis Byrne, Paul Hwang, Sandra Collins Thompson, Kitos, Paul A.

“…A sensitive method has been developed for visualizing eukaryotic cells in mitosis (M) phase. It employs Zenker's fixative, which makes the plasma membrane but…”
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10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): A potent inhibitor of glycinamide ribonucleotide transformylase by Boger, Dale L., Haynes, Nancy-Ellen, Kitos, Paul A., Warren, Mark S., Ramcharan, Joseph, Marolewski, Ariane E., Benkovic, Stephen J.

“…The synthesis of 10-formyl-5,8,10-trideazafolic acid ( 3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) is reported. The…”
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Effects of molecular oxygen on chick limb bud chondrogenesis by Hwang, P M, Byrne, D H, Kitos, P A

“…Chondrogenesis is an important process in the development of the embryonic chick limb. If limb buds are dispersed just prior to the initiation of chondrogenic…”
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Effects of diazinon on nucleotide and amino acid contents of chick embryos. Teratogenic considerations by Kushaba-Rugaaju, S, Kitos, P A

“…The effects of diazinon (DZN), an organophosphorus (OP) insecticide, and nicotinamide (Nam) on the pyridine nucleotide, purine and pyrimidine ribonucleotides,…”
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The isolation of polyadenylate with unreacted cellulose by Kitos, P A, Saxon, G, Amos, H

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Identification of Serine Esterases in Tissue Homogenates by Keshavarz-Shokri, Ali, Suntornwat, Oranart, Kitos, Paul A.

“…Serine esterases react with [3H]diisopropylphosphofluoridate ([3H]DFP) to produce radioactive adducts that can be resolved by denaturing slab gel…”
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Proton induced x-ray emission analysis of L-cells grown in vitro by Zombola, R. R, Kitos, P. A, Bearse, R. C

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Action of Ribonuclease upon the Polysomes of Cultured Mouse Cells by Richards, K., P. A. Kitos, Hersh, R. T.

“…Pancreatic ribonuclease (RNase) and3H-uridine were used to study certain compositional and ontogenetic features of the polysomes of strain L mouse cells…”
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Is G1 normally distributed? by Hersh, R T, Kitos, P A

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Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase by Boger, Dale L., Haynes, Nancy-Ellen, Warren, Mark S., Gooljarsingh, Lata T., Ramcharan, Joseph, Kitos, Paul A., Benkovic, Stephen J.

“…A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase…”
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Functionalized analogues of 5,8,10-trideazafolate: Development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase by Boger, Dale L., Haynes, Nancy-Ellen, Warren, Mark S., Ramcharan, Joseph, Kitos, Paul A., Benkovic, Stephen J.

“…A set of inhibitors 3 and 4 of GAR and AICAR Tfase based on the TDAF core which contain an sp 2 C-10 carbon atom replacing N-10 of the natural cofactor are…”
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