Search Results - "Kitchner, Terrie E."

PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies by Hall, Molly A., Wallace, John, Lucas, Anastasia, Kim, Dokyoon, Basile, Anna O., Verma, Shefali S., McCarty, Cathy A., Brilliant, Murray H., Peissig, Peggy L., Kitchner, Terrie E., Verma, Anurag, Pendergrass, Sarah A., Dudek, Scott M., Moore, Jason H., Ritchie, Marylyn D.

“…Genome-wide, imputed, sequence, and structural data are now available for exceedingly large sample sizes. The needs for data management, handling population…”
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A GWAS Study on Liver Function Test Using eMERGE Network Participants by Namjou, Bahram, Marsolo, Keith, Lingren, Todd, Ritchie, Marylyn D, Verma, Shefali S, Cobb, Beth L, Perry, Cassandra, Kitchner, Terrie E, Brilliant, Murray H, Peissig, Peggy L, Borthwick, Kenneth M, Williams, Marc S, Grafton, Jane, Jarvik, Gail P, Holm, Ingrid A, Harley, John B

“…Liver enzyme levels and total serum bilirubin are under genetic control and in recent years genome-wide population-based association studies have identified…”
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Intraocular Pressure Response to Medication in a Clinical Setting: The Marshfield Clinic Personalized Medicine Research Project by McCarty, Catherine A, Mukesh, Bickol N, Kitchner, Terrie E, Hubbard, William C, Wilke, Russell A, Burmester, James K, Patchett, Richard B

“…PURPOSETo estimate glaucoma and ocular hypertension prevalence and to describe temporal trends in prescribing patterns and intraocular pressure (IOP) response…”
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Desiderata for computable representations of electronic health records-driven phenotype algorithms by Mo, Huan, Thompson, William K, Rasmussen, Luke V, Pacheco, Jennifer A, Jiang, Guoqian, Kiefer, Richard, Zhu, Qian, Xu, Jie, Montague, Enid, Carrell, David S, Lingren, Todd, Mentch, Frank D, Ni, Yizhao, Wehbe, Firas H, Peissig, Peggy L, Tromp, Gerard, Larson, Eric B, Chute, Christopher G, Pathak, Jyotishman, Denny, Joshua C, Speltz, Peter, Kho, Abel N, Jarvik, Gail P, Bejan, Cosmin A, Williams, Marc S, Borthwick, Kenneth, Kitchner, Terrie E, Roden, Dan M, Harris, Paul A

“…Background Electronic health records (EHRs) are increasingly used for clinical and translational research through the creation of phenotype algorithms…”
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Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network by Gallego, Carlos J., Burt, Amber, Sundaresan, Agnes S., Ye, Zi, Shaw, Christopher, Crosslin, David R., Crane, Paul K., Fullerton, S. Malia, Hansen, Kris, Carrell, David, Kuivaniemi, Helena, Derr, Kimberly, de Andrade, Mariza, McCarty, Catherine A., Kitchner, Terrie E., Ragon, Brittany K., Stallings, Sarah C., Papa, Gabriella, Bochenek, Joseph, Smith, Maureen E., Aufox, Sharon A., Pacheco, Jennifer A., Patel, Vaibhav, Friesema, Elisha M., Erwin, Angelika Ludtke, Gottesman, Omri, Gerhard, Glenn S., Ritchie, Marylyn, Motulsky, Arno G., Kullo, Iftikhar J., Larson, Eric B., Tromp, Gerard, Brilliant, Murray H., Bottinger, Erwin, Denny, Joshua C., Roden, Dan M., Williams, Marc S., Jarvik, Gail P.

“…Hereditary hemochromatosis (HH) is a common autosomal-recessive disorder associated with pathogenic HFE variants, most commonly those resulting in p.Cys282Tyr…”
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CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease by Hoh, Brian L, Gong, Yan, McDonough, Caitrin W, Waters, Michael F, Royster, Adrienne J, Sheehan, Tiffany O, Burkley, Ben, Langaee, Taimour Y, Mocco, J, Zuckerman, Scott L, Mummareddy, Nishit, Stephens, 2nd, Marcus L, Ingram, Christie, Shaffer, Christian M, Denny, Joshua C, Brilliant, Murray H, Kitchner, Terrie E, Linneman, James G, Roden, Dan M, Johnson, Julie A

“…OBJECT Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent stroke. Genetic polymorphisms in CYP2C19 and CES1 are associated…”
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Enrichment sampling for a multi-site patient survey using electronic health records and census data by Mercaldo, Nathaniel D, Brothers, Kyle B, Carrell, David S, Clayton, Ellen W, Connolly, John J, Holm, Ingrid A, Horowitz, Carol R, Jarvik, Gail P, Kitchner, Terrie E, Li, Rongling, McCarty, Catherine A, McCormick, Jennifer B, McManus, Valerie D, Myers, Melanie F, Pankratz, Joshua J, Shrubsole, Martha J, Smith, Maureen E, Stallings, Sarah C, Williams, Janet L, Schildcrout, Jonathan S

“…We describe a stratified sampling design that combines electronic health records (EHRs) and United States Census (USC) data to construct the sampling frame and…”
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Analysis of CYP1B1 in pediatric and adult glaucoma and other ocular phenotypes by Reis, Linda M, Tyler, Rebecca C, Weh, Eric, Hendee, Kathryn E, Kariminejad, Ariana, Abdul-Rahman, Omar, Ben-Omran, Tawfeg, Manning, Melanie A, Yesilyurt, Ahmet, McCarty, Catherine A, Kitchner, Terrie E, Costakos, Deborah, Semina, Elena V

“…The gene encodes an enzyme that is a member of the cytochrome P450 superfamily. Mutations in have been mainly reported in recessive pediatric ocular…”
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Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy by Van Driest, Sara L, McGregor, Tracy L, Velez Edwards, Digna R, Saville, Ben R, Kitchner, Terrie E, Hebbring, Scott J, Brilliant, Murray, Jouni, Hayan, Kullo, Iftikhar J, Creech, C Buddy, Kannankeril, Prince J, Vear, Susan I, Brothers, Kyle B, Bowton, Erica A, Shaffer, Christian M, Patel, Neelam, Delaney, Jessica T, Bradford, Yuki, Wilson, Sarah, Olson, Lana M, Crawford, Dana C, Potts, Amy L, Ho, Richard H, Roden, Dan M, Denny, Josh C

“…Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and…”
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CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids by Dahlin, Amber, Denny, Joshua, Roden, Dan M., Brilliant, Murray H., Ingram, Christie, Kitchner, Terrie E., Linneman, James G., Shaffer, Christian M., Weeke, Peter, Xu, Hua, Kubo, Michiaki, Tamari, Mayumi, Clemmer, George L., Ziniti, John, McGeachie, Michael J., Tantisira, Kelan G., Weiss, Scott T., Wu, Ann Chen

“…Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation…”
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A novel gene–environment interaction involved in endometriosis by McCarty, Catherine A, Berg, Richard L, Welter, Joseph D, Kitchner, Terrie E, Kemnitz, Joseph W

“…Abstract Objective To establish a well-defined cohort for genetic epidemiology studies of endometriosis and conduct a pilot study to confirm validity using…”
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Public Attitudes toward Consent and Data Sharing in Biobank Research: A Large Multi-site Experimental Survey in the US by Sanderson, Saskia C., Brothers, Kyle B., Mercaldo, Nathaniel D., Clayton, Ellen Wright, Antommaria, Armand H. Matheny, Aufox, Sharon A., Brilliant, Murray H., Campos, Diego, Carrell, David S., Connolly, John, Conway, Pat, Fullerton, Stephanie M., Garrison, Nanibaa’ A., Horowitz, Carol R., Jarvik, Gail P., Kaufman, David, Kitchner, Terrie E., Li, Rongling, Ludman, Evette J., McCarty, Catherine A., McCormick, Jennifer B., McManus, Valerie D., Myers, Melanie F., Scrol, Aaron, Williams, Janet L., Shrubsole, Martha J., Schildcrout, Jonathan S., Smith, Maureen E., Holm, Ingrid A.

“…Individuals participating in biobanks and other large research projects are increasingly asked to provide broad consent for open-ended research use and…”
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Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration: A Mendelian Randomization Study by Kuan, Valerie, Warwick, Alasdair, Hingorani, Aroon, Tufail, Adnan, Cipriani, Valentina, Burgess, Stephen, Sofat, Reecha

“…Advanced age-related macular degeneration (AMD) is a leading cause of blindness in Western countries. Causal, modifiable risk factors need to be identified to…”
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Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records by Van Driest, Sara L, Wells, Quinn S, Stallings, Sarah, Bush, William S, Gordon, Adam, Nickerson, Deborah A, Kim, Jerry H, Crosslin, David R, Jarvik, Gail P, Carrell, David S, Ralston, James D, Larson, Eric B, Bielinski, Suzette J, Olson, Janet E, Ye, Zi, Kullo, Iftikhar J, Abul-Husn, Noura S, Scott, Stuart A, Bottinger, Erwin, Almoguera, Berta, Connolly, John, Chiavacci, Rosetta, Hakonarson, Hakon, Rasmussen-Torvik, Laura J, Pan, Vivian, Persell, Stephen D, Smith, Maureen, Chisholm, Rex L, Kitchner, Terrie E, He, Max M, Brilliant, Murray H, Wallace, John R, Doheny, Kimberly F, Shoemaker, M. Benjamin, Li, Rongling, Manolio, Teri A, Callis, Thomas E, Macaya, Daniela, Williams, Marc S, Carey, David, Kapplinger, Jamie D, Ackerman, Michael J, Ritchie, Marylyn D, Denny, Joshua C, Roden, Dan M

“…IMPORTANCE: Large-scale DNA sequencing identifies incidental rare variants in established Mendelian disease genes, but the frequency of related clinical…”
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Probing the Virtual Proteome to Identify Novel Disease Biomarkers by Mosley, Jonathan D, Benson, Mark D, Smith, J Gustav, Melander, Olle, Ngo, Debby, Shaffer, Christian M, Ferguson, Jane F, Herzig, Matthew S, McCarty, Catherine A, Chute, Christopher G, Jarvik, Gail P, Gordon, Adam S, Palmer, Melody R, Crosslin, David R, Larson, Eric B, Carrell, David S, Kullo, Iftikhar J, Pacheco, Jennifer A, Peissig, Peggy L, Brilliant, Murray H, Kitchner, Terrie E, Linneman, James G, Namjou, Bahram, Williams, Marc S, Ritchie, Marylyn D, Borthwick, Kenneth M, Kiryluk, Krzysztof, Mentch, Frank D, Sleiman, Patrick M, Karlson, Elizabeth W, Verma, Shefali S, Zhu, Yineng, Vasan, Ramachandran S, Yang, Qiong, Denny, Josh C, Roden, Dan M, Gerszten, Robert E, Wang, Thomas J

“…BACKGROUND:Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying…”
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Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration by Waksmunski, Andrea R, Grunin, Michelle, Kinzy, Tyler G, Igo, Jr, Robert P, Haines, Jonathan L, Cooke Bailey, Jessica N

“…Age-related macular degeneration (AMD) is the worldwide leading cause of blindness among the elderly. Although genome-wide association studies (GWAS) have…”
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Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits by Grassmann, Felix, Kiel, Christina, Zimmermann, Martina E, Gorski, Mathias, Grassmann, Veronika, Stark, Klaus, Heid, Iris M, Weber, Bernhard H F

“…Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors…”
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A polymorphism in HLA-G modifies statin benefit in asthma by Naidoo, D, Wu, A C, Brilliant, M H, Denny, J, Ingram, C, Kitchner, T E, Linneman, J G, McGeachie, M J, Roden, D M, Shaffer, C M, Shah, A, Weeke, P, Weiss, S T, Xu, H, Medina, M W

“…Several reports have shown that statin treatment benefits patients with asthma; however, inconsistent effects have been observed. The mir-152 family (148a,…”
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Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy: e0127791 by Driest, Sara LVan, McGregor, Tracy L, Edwards, Digna RVelez, Saville, Ben R, Kitchner, Terrie E, Hebbring, Scott J, Brilliant, Murray, Jouni, Hayan, Kullo, Iftikhar J, Creech, C Buddy

“…Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and…”
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