Search Results - "Kitching, ARichard"

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase by Odobasic, Dragana, Holdsworth, Stephen R., Kitching, A. Richard

“…Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection…”
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CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages by Engel, Daniel R, Krause, Torsten A, Snelgrove, Sarah L, Thiebes, Stephanie, Hickey, Michael J, Boor, Peter, Kitching, A Richard, Kurts, Christian

“…A dense network of macrophages and dendritic cells (DC) expressing the chemokine receptor CX3CR1 populates most tissues. We recently reported that CX3CR1…”
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Leukocyte Recruitment to the Inflamed Glomerulus: A Critical Role for Platelet-Derived P-Selectin in the Absence of Rolling by Kuligowski, Michael P, Kitching, A. Richard, Hickey, Michael J

“…The renal glomerulus is one of the few sites within the microvasculature in which leukocyte recruitment occurs in capillaries. However, due to the difficulty…”
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Myeloperoxidase-specific antineutrophil cytoplasmic antibody-associated vasculitis by Arnold, Sabrina, Kitching, A Richard, Witko-Sarsat, Veronique, Wiech, Thorsten, Specks, Ulrich, Klapa, Sebastian, Comdühr, Sara, Stähle, Anja, Müller, Antje, Lamprecht, Peter

“…Myeloperoxidase (MPO)-specific antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (MPO-ANCA-associated vasculitis) is one of two major…”
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Deficiency of annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation by Yang, Yuan H, Song, Wuqi, Deane, James A, Kao, Wenping, Ooi, Joshua D, Ngo, Devi, Kitching, A Richard, Morand, Eric F, Hickey, Michael J

“…Annexin A1 (AnxA1) is recognized as an endogenous anti-inflammatory molecule. However, its effects on the adaptive immune response and, in particular, on T…”
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Suppression of Autoimmunity and Renal Disease in Pristane‐Induced Lupus by Myeloperoxidase by Odobasic, Dragana, Muljadi, Ruth C. M., O'Sullivan, Kim M., Kettle, Anthony J., Dickerhof, Nina, Summers, Shaun A., Kitching, A. Richard, Holdsworth, Stephen R.

“…Objective Myeloperoxidase (MPO) locally contributes to organ damage in various chronic inflammatory conditions by generating reactive intermediates. The…”
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Regulatory T cells dynamically regulate selectin ligand function during multiple challenge contact hypersensitivity by Abeynaike, Latasha D, Deane, James A, Westhorpe, Clare L V, Chow, Zachary, Alikhan, Maliha A, Kitching, A Richard, Issekutz, Andrew, Hickey, Michael J

“…Regulatory T cells (Tregs) play critical roles in restricting T cell-mediated inflammation. In the skin, this is dependent on expression of selectin ligands…”
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Endogenous regulatory T cells adhere in inflamed dermal vessels via ICAM-1: association with regulation of effector leukocyte adhesion by Deane, James A, Abeynaike, Latasha D, Norman, M Ursula, Wee, Janet L, Kitching, A Richard, Kubes, Paul, Hickey, Michael J

“…Regulatory T cells (Tregs) must express appropriate skin-homing adhesion molecules to exert suppressive effects on dermal inflammation. However, the mechanisms…”
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IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis by Jones, Lynelle K., O’Sullivan, Kim M., Semple, Timothy, Kuligowski, Michael P., Fukami, Kei, Ma, Frank Y., Nikolic-Paterson, David J., Holdsworth, Stephen R., Kitching, A. Richard

“…Background. IL-1β has the potential to promote progressive renal disease by effects on macrophage recruitment and activation or by effects mediated through…”
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Macrophage Migration Inhibitory Factor Deficiency Attenuates Macrophage Recruitment, Glomerulonephritis, and Lethality in MRL/lpr Mice by Hoi, Alberta Y, Hickey, Michael J, Hall, Pamela, Yamana, Jiro, O'Sullivan, Kim M, Santos, Leilani L, James, Will G, Kitching, A. Richard, Morand, Eric F

“…Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disease of unknown etiology. Macrophage migration inhibitory factor (MIF) is a…”
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Proteolysis Breaks Tolerance toward Intact alpha 345(IV) Collagen, Eliciting Novel Anti-Glomerular Basement Membrane Autoantibodies Specific for alpha 345NC1 Hexamers by Olaru, Florina, Wang, Xu-Ping, Luo, Wentian, Ge, Linna, Miner, Jeffrey H, Kleinau, Sandra, Geiger, Xochiquetzal J, Wasiluk, Andrew, Heidet, Laurence, Kitching, ARichard, Borza, Dorin-Bogdan

“…Goodpasture disease is an autoimmune kidney disease mediated by autoantibodies against noncollagenous domain 1 (NC1) monomers of alpha 3(IV) collagen that bind…”
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CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms by Odobasic, Dragana, Kitching, A. Richard, Tipping, Peter G., Holdsworth, Stephen R.

“…CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. CD80 and CD86 costimulatory molecules have been shown to…”
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Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antibody in injury by Dean, Elizabeth G., Wilson, Gabrielle R.A., Li, Ming, Edgtton, Kristy L., O'Sullivan, Kim M., Hudson, Billy G., Holdsworth, Stephen R., Richard Kitching, A.

“…Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antibody in injury. Goodpasture's disease [antiglomerular…”
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CD100 Enhances Dendritic Cell and CD4 super(+) Cell Activation Leading to Pathogenetic Humoral Responses and Immune Complex Glomerulonephritis by Li, Ming, O'Sullivan, Kim M, Jones, Lynelle K, Semple, Timothy, Kumanogoh, Atsushi, Kikutani, Hitoshi, Holdsworth, Stephen R, Kitching, ARichard

“…CD100, a member of the semaphorin family, is a costimulatory molecule in adaptive immune responses by switching off CD72's negative signals. However, CD100's…”
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An IL-12-Independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-Mediated Glomerulonephritis and Dermal Delayed-Type Hypersensitivity by Ruth, Amanda-Jane, Kitching, A. Richard, Li, Ming, Semple, Timothy J, Timoshanko, Jennifer R, Tipping, Peter G, Holdsworth, Stephen R

“…Crescentic glomerulonephritis (GN) results from IL-12-driven Th1-directed cell-mediated responses (akin to delayed-type hypersensitivity (DTH)) directed…”
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