Search Results - "Kitchin, Kirk"

Arsenic-Induced CarcinogenesisOxidative Stress as a Possible Mode of Action and Future Research Needs for More Biologically Based Risk Assessment by Kitchin, Kirk T, Conolly, Rory

“…Exposure to inorganic arsenic (iAs) induces cancer in human lungs, urinary bladder, skin, kidney, and liver, with the majority of deaths from lung and bladder…”
Get full text

The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity by Kitchin, Kirk T., Wallace, Kathleen

“…Three of the most plausible biological theories of arsenic carcinogenesis are protein binding, oxidative stress and altered DNA methylation. This review…”
Get full text

Metabolomic effects of CeO2, SiO2 and CuO metal oxide nanomaterials on HepG2 cells by Kitchin, Kirk T, Stirdivant, Steve, Robinette, Brian L, Castellon, Benjamin T, Liang, Xinhua

“…To better assess potential hepatotoxicity of nanomaterials, human liver HepG2 cells were exposed for 3 days to five different CeO.sub.2 (either 30 or 100…”
Get full text

Recent Advances in Arsenic Carcinogenesis: Modes of Action, Animal Model Systems, and Methylated Arsenic Metabolites by Kitchin, Kirk T.

“…Recent advances in our knowledge of arsenic carcinogenesis include the development of rat or mouse models for all human organs in which inorganic arsenic is…”
Get full text

Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells by Thai, Sheau-Fung, Jones, Carlton P, Robinette, Brian L, Ren, Hongzu, Vallant, Beena, Fisher, Anna, Kitchin, Kirk T

“…With the advancement of nanotechnology, nanoparticles are widely used in many different industrial processes and consumer products. Copper nanoparticles (Cu…”
Get more information

Biochemical effects of copper nanomaterials in human hepatocellular carcinoma (HepG2) cells by Kitchin, Kirk T., Richards, Judy A., Robinette, Brian L., Wallace, Kathleen A., Coates, Najwa H., Castellon, Benjamin T., Grulke, Eric A.

“…In dose-response and structure-activity studies, human hepatic HepG2 cells were exposed for 3 days to nano Cu, nano CuO or CuCl 2 (ions) at doses between 0.1…”
Get full text

Biochemical Effects of Silver Nanomaterials in Human Hepatocellular Carcinoma (HepG2) Cells by Kitchin, Kirk T, Richards, Judy A, Robinette, Brian L, Wallace, Kathleen A, Coates, Najwa H, Castellon, Benjamin T, Grulke, Eric A, Kou, Jiahui, Varma, Rajender S

“…In dose-response and structure-activity studies, human hepatic HepG2 cells were exposed to between 0.01 and 300 ug/ml of different silver nanomaterials and…”
Get more information

Oxidative stress as a possible mode of action for arsenic carcinogenesis by Kitchin, Kirk T, Ahmad, Sarfaraz

“…Many modes of action for arsenic carcinogenesis have been proposed, but few theories have a substantial mass of supporting data. Three stronger theories of…”
Get full text

Arsenite binding to synthetic peptides based on the Zn finger region and the estrogen binding region of the human estrogen receptor-α by Kitchin, Kirk T., Wallace, Kathleen

“…We selected the estrogen receptor protein for study because of prior results indicating that arsenite is a “potential nonsteroidal environmental estrogen”. We…”
Get full text

Differential Genomic Effects on Signaling Pathways by Two Different CeO2 Nanoparticles in HepG2 Cells by Thai, Sheau-Fung, Wallace, Kathleen A, Jones, Carlton P, Ren, Hongzu, Castellon, Benjamin T, Crooks, James, Grulke, Eric A, Kitchin, Kirk T

“…To investigate genomic effects, human liver hepatocellular carcinoma (HepG2) cells were exposed for three days to two different forms of nanoparticles both…”
Get more information

Differential Genomic Effects of Six Different TiO2 Nanomaterials on Human Liver HepG2 Cells by Thai, Sheau-Fung, Wallace, Kathleen A., Jones, Carlton P., Ren, Hongzu, Grulke, Eric, Castellon, Benjamin T., Crooks, James, Kitchin, Kirk T.

“…ABSTRACT Human HepG2 cells were exposed to six TiO2 nanomaterials (with dry primary particle sizes ranging from 22 to 214 nm, either 0.3, 3, or 30 μg/mL) for 3…”
Get full text

Evidence against the nuclear in situ binding of arsenicals–oxidative stress theory of arsenic carcinogenesis by Kitchin, Kirk T., Wallace, Kathleen

“…A large amount of evidence suggests that arsenicals act via oxidative stress in causing cancer in humans and experimental animals. It is possible that…”
Get full text

Oxidative stress studies of six TiO2 and two CeO2 nanomaterials: Immuno-spin trapping results with DNA by Kitchin, Kirk T., Prasad, Raju Y., Wallace, Kathleen

“…Abstract Six TiO2 and two CeO2 nanomaterials with dry sizes ranging from 6-410 nm were tested for their ability to cause DNA centered free radicals in vitro in…”
Get full text

Biochemical effects of some CeO 2 , SiO 2 , and TiO 2 nanomaterials in HepG2 cells by Kitchin, Kirk T, Richards, Judy A, Robinette, Brian L, Wallace, Kathleen A, Coates, Najwa H, Castellon, Benjamin T, Grulke, Eric A

“…The potential mammalian hepatotoxicity of nanomaterials was explored in dose-response and structure-activity studies in human hepatic HepG2 cells exposed to…”
Get full text

Biochemical effects of some CeO2, SiO2, and TiO2 nanomaterials in HepG2 cells by Kitchin, Kirk T., Richards, Judy A., Robinette, Brian L., Wallace, Kathleen A., Coates, Najwa H., Castellon, Benjamin T., Grulke, Eric A.

“…The potential mammalian hepatotoxicity of nanomaterials was explored in dose-response and structure-activity studies in human hepatic HepG2 cells exposed to…”
Get full text

Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid by Chilakapati, Jaya, Wallace, Kathleen, Ren, Hongzu, Fricke, Michael, Bailey, Kathryn, Ward, William, Creed, Jack, Kitchin, Kirk

“…Abstract Lung is a major target for arsenic carcinogenesis in humans by both oral and inhalation routes. However, the carcinogenic mode of action of arsenicals…”
Get full text

Do Arsenosugars Pose a Risk to Human Health? The Comparative Toxicities of a Trivalent and Pentavalent Arsenosugar by Andrewes, Paul, DeMarini, David M, Funasaka, Kunihiro, Wallace, Kathleen, Lai, Vivian W. M, Sun, Hongsui, Cullen, William R, Kitchin, Kirk T

“…Seafood frequently contains high concentrations of arsenic (∼10−100 mg/kg dry weight). In marine algae (seaweed), this arsenic occurs predominantly as ribose…”
Get full text

Measurement of oxidative stress parameters using liquid chromatography–tandem mass spectroscopy (LC–MS/MS) by Winnik, Witold M., Kitchin, Kirk T.

“…There is increasingly intense scientific and clinical interest in oxidative stress and the many parameters used to quantify the degree of oxidative stress…”
Get full text

Pharmacokinetic and Genomic Effects of Arsenite in Drinking Water on Mouse Lung in a 30-Day Exposure by Chilakapati, Jaya, Wallace, Kathleen, Hernandez-Zavala, Araceli, Moore, Tanya, Ren, Hongzu, Kitchin, Kirk T.

“…The 2 objectives of this subchronic study were to determine the arsenite drinking water exposure dependent increases in female C3H mouse liver and lung tissue…”
Get full text

Dissociation of arsenite-peptide complexes: Triphasic nature, rate constants, half-lives, and biological importance by Kitchin, Kirk T., Wallace, Kathleen

“…We determined the number and the dissociation rate constants of different complexes formed from arsenite and two peptides containing either one…”
Get full text