Search Results - "Kitazato, Keiko T."

Roles of Hypertension in the Rupture of Intracranial Aneurysms by TADA, Yoshiteru, WADA, Kosuke, SHIMADA, Kenji, MAKINO, Hiroshi, LIANG, Elena I, MURAKAMI, Shoko, KUDO, Mari, KITAZATO, Keiko T, NAGAHIRO, Shinji, HASHIMOTO, Tomoki

“…Systemic hypertension has long been considered a risk factor of aneurysmal rupture. However, a causal link between systemic hypertension and the development of…”
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Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma by Shono, Kenji, Yamaguchi, Izumi, Mizobuchi, Yoshifumi, Kagusa, Hiroshi, Sumi, Akiko, Fujihara, Toshitaka, Nakajima, Kohei, Kitazato, Keiko T., Matsuzaki, Kazuhito, Saya, Hideyuki, Takagi, Yasushi

“…Glioblastoma multiforme involves glioma stem cells (GSCs) that are resistant to various therapeutic approaches. Here, we studied the importance of paracrine…”
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Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage by Kurashiki, Yoshitaka, Kagusa, Hiroshi, Yagi, Kenji, Kinouchi, Tomoya, Sumiyoshi, Manabu, Miyamoto, Takeshi, Shimada, Kenji, Kitazato, Keiko T, Uto, Yoshihiro, Takagi, Yasushi

“…Cerebral ischemia triggers inflammatory changes, and early complications and unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the…”
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Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats by Maekawa, Hidetsugu, Tada, Yoshiteru, Yagi, Kenji, Miyamoto, Takeshi, Kitazato, Keiko T, Korai, Masaaki, Satomi, Junichiro, Hashimoto, Tomoki, Nagahiro, Shinji

“…Estrogen deficiency is thought to be responsible for the higher frequency of aneurysmal subarachnoid hemorrhage in post- than premenopausal women. Estrogen…”
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An imbalance between RAGE/MR/HMGB1 and ATP1α3 is associated with inflammatory changes in rat brain harboring cerebral aneurysms prone to rupture by Shikata, Eiji, Miyamoto, Takeshi, Yamaguchi, Tadashi, Yamaguchi, Izumi, Kagusa, Hiroshi, Gotoh, Daiki, Shimada, Kenji, Tada, Yoshiteru, Yagi, Kenji, Kitazato, Keiko T., Kanematsu, Yasuhisa, Takagi, Yasushi

“…Background and purpose An aneurysmal subarachnoid hemorrhage is a devastating event. To establish an effective therapeutic strategy, its pathogenesis must be…”
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Roles of Estrogen in the Formation of Intracranial Aneurysms in Ovariectomized Female Mice by Tada, Yoshiteru, Makino, Hiroshi, Furukawa, Hajime, Shimada, Kenji, Wada, Kosuke, Liang, Elena I., Murakami, Shoko, Kudo, Mari, Kung, David K., Hasan, David M., Kitazato, Keiko T., Nagahiro, Shinji, Lawton, Michael T., Hashimoto, Tomoki

“…Abstract Background: Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same…”
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Estrogen Protects Against Intracranial Aneurysm Rupture in Ovariectomized Mice by TADA, Yoshiteru, WADA, Kosuke, HASAN, David M, KANEMATSU, Yasuhisa, NAGAHIRO, Shinji, HASHIMOTO, Tomoki, SHIMADA, Kenji, MAKINO, Hiroshi, LIANG, Elena I, MURAKAMI, Shoko, KUDO, Mari, SHIKATA, Fumiaki, PENA SILVA, Ricardo A, KITAZATO, Keiko T

“…Clinical observations suggest that postmenopausal women have a higher incidence of aneurysmal rupture than premenopausal women. We hypothesize that a relative…”
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Endothelial injury and inflammatory response induced by hemodynamic changes preceding intracranial aneurysm formation : experimental study in rats by JAMOUS, Mohammad A, NAGAHIRO, Shinji, KITAZATO, Keiko T, TAMURA, Tetsuya, HANI ABDEL AZIZ, SHONO, Masayuki, SATOH, Koichi

“…Intracranial aneurysms are the leading cause of subarachnoid hemorrhage, which is associated with high morbidity and mortality rates. Despite advances in the…”
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Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats by Korai, Masaaki, Kitazato, Keiko T, Tada, Yoshiteru, Miyamoto, Takeshi, Shimada, Kenji, Matsushita, Nobuhisa, Kanematsu, Yasuhisa, Satomi, Junichiro, Hashimoto, Tomoki, Nagahiro, Shinji

“…Hyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall. However,…”
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Importance of Managing the Water-Electrolyte Balance by Delivering the Optimal Minimum Amount of Water and Sodium After Subarachnoid Hemorrhage by Shikata, Eiji, Tamura, Tetsuya, Shinno, Kiyohito, Okayama, Yoshihiro, Shinohara, Naoki, Shimada, Kenji, Kanematsu, Yasuhisa, Kitazato, Keiko T., Nagahiro, Shinji, Takagi, Yasushi

“…After aneurysmal subarachnoid hemorrhage (aSAH), crystalloid fluids with a relatively high sodium concentration have been used to maintain the cerebral blood…”
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Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats by Tamura, Tetsuya, Jamous, Mohammad A, Kitazato, Keiko T, Yagi, Kenji, Tada, Yoshiteru, Uno, Masaaki, Nagahiro, Shinji

“…OBJECTIVEEpidemiological data indicate a high incidence of cerebral aneurysms in postmenopausal women. To elucidate the pathogenesis of cerebral aneurysms, we…”
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Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats by TADA, Yoshiteru, YAGI, Kenji, NAGAHIRO, Shinji, KITAZATO, Keiko T, TAMURA, Tetsuya, KINOUCHI, Tomoya, SHIMADA, Kenji, MATSUSHITA, Nobuhisa, NAKAJIMA, Norio, SATOMI, Junichiro, KAGEJI, Teruyoshi

“…The formation of cerebral aneurysms is associated with endothelial damage and macrophage migration. Hypothesizing that the opening of tight junctions due to…”
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Statins Promote the Growth of Experimentally Induced Cerebral Aneurysms in Estrogen-Deficient Rats by TADA, Yoshiteru, KITAZATO, Keiko T, YAGI, Kenji, SHIMADA, Kenji, MATSUSHITA, Nobuhisa, KINOUCHI, Tomoya, KANEMATSU, Yasuhisa, SATOMI, Junichiro, KAGEJI, Teruyoshi, NAGAHIRO, Shinji

“…The pathogenesis of cerebral aneurysms is linked to inflammation, degradation of the extracellular matrix, and vascular wall apoptosis. Statins exert…”
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Role of Mineralocorticoid Receptor on Experimental Cerebral Aneurysms in Rats by Tada, Yoshiteru, Kitazato, Keiko T, Tamura, Tetsuya, Yagi, Kenji, Shimada, Kenji, Kinouchi, Tomoya, Satomi, Junichiro, Nagahiro, Shinji

“…Activation of the renin-angiotensin (Ang)-aldosterone system is involved in the pathology of vascular diseases. Although the blockade of the mineralocorticoid…”
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Intra-arterial high signals on arterial spin labeling perfusion images predict the occluded internal carotid artery segment by Sogabe, Shu, Satomi, Junichiro, Tada, Yoshiteru, Kanematsu, Yasuhisa, Kuwayama, Kazuyuki, Yagi, Kenji, Yoshioka, Shotaro, Mizobuchi, Yoshifumi, Mure, Hideo, Yamaguchi, Izumi, Abe, Takashi, Yamamoto, Nobuaki, Kitazato, Keiko T., Kaji, Ryuji, Harada, Masafumi, Nagahiro, Shinji

“…Purpose Arterial spin labeling (ASL) involves perfusion imaging using the inverted magnetization of arterial water. If the arterial arrival times are longer…”
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Activation of Signal Transducer and Activator of Transcription-3 by a Peroxisome Proliferator-Activated Receptor Gamma Agonist Contributes to Neuroprotection in the Peri-Infarct Region After Ischemia in Oophorectomized Rats by KINOUCHI, Tomoya, KITAZATO, Keiko T, SHIMADA, Kenji, YAGI, Kenji, TADA, Yoshiteru, MATSUSHITA, Nobuhisa, SUMIYOSHI, Manabu, SATOMI, Junichiro, KAGEJI, Teruyoshi, NAGAHIRO, Shinji

“…The role of the phosphorylated signal transducer and activator of transcription-3 (p-STAT3) after cerebral ischemia by the peroxisome proliferator-activated…”
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Active Cancer and Elevated D-Dimer Are Risk Factors for In-Hospital Ischemic Stroke by Yamaguchi, Izumi, Kanematsu, Yasuhisa, Shimada, Kenji, Korai, Masaaki, Miyamoto, Takeshi, Shikata, Eiji, Yamaguchi, Tadashi, Yamamoto, Nobuaki, Yamamoto, Yuki, Kitazato, Keiko T., Okayama, Yoshihiro, Takagi, Yasushi

“…Background and Purpose: Little attention has been paid to the pathogenesis of in-hospital stroke, despite poor outcomes and a longer time from stroke onset to…”
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PPARγ-Dependent and -Independent Inhibition of the HMGB1/TLR9 Pathway by Eicosapentaenoic Acid Attenuates Ischemic Brain Damage in Ovariectomized Rats by Sumiyoshi, Manabu, MD, Satomi, Junichiro, MD, PhD, Kitazato, Keiko T., MS, Yagi, Kenji, MD, PhD, Shimada, Kenji, MD, PhD, Kurashiki, Yoshitaka, MD, Korai, Masaaki, MD, Miyamoto, Takeshi, MD, Suzue, Ryoko, MD, Kuwayama, Kazuyuki, MD, PhD, Nagahiro, Shinji, MD, PhD

“…High mobility group box 1 (HMGB1) elevation after cerebral ischemia activates inflammatory pathways via receptors such as the receptor for advanced glycation…”
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Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies by Liu, Hao, Kitazato, Keiko T, Uno, Masaaki, Yagi, Kenji, Kanematsu, Yasuhisa, Tamura, Tetsuya, Tada, Yoshiteru, Kinouchi, Tomoya, Nagahiro, Shinji

“…BACKGROUNDAngiotensin II type 1 (AT1) receptor blockers decrease ischemia by mechanisms dependent on and independent of arterial blood pressure in hypertensive…”
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Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part II: experimental study of the effects of hormone replacement therapy in rats by JAMOUS, Mohammad A, NAGAHIRO, Shinji, KITAZATO, Keiko T, TAMURA, Tetsuya, KUWAYAMA, Kazuyuki, SATOH, Koichi

“…The increased incidence of cerebral aneurysms in postmenopausal women appears to be related to low levels of circulating estrogen. Using a rat model of…”
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