Search Results - "Kitani, Kenichi"

The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice by KITANI, Kenichi, OSAWA, Toshihiko, YOKOZAWA, Takako

“…The effect of feeding of two different antioxidants, tetrahydrocurcumin (TC) and green tea polyphenols (PPs) on the survival of male C57BL/6 mice was examined…”
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Antioxidative Activity of Green Tea Polyphenol in Cholesterol-Fed Rats by Yokozawa, Takako, Nakagawa, Takako, Kitani, Kenichi

“…This study investigated the effects of green tea polyphenol on the serum antioxidative activity and cholesterol levels of cholesterol-fed rats and compared…”
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Pharmacological interventions in aging and age-associated disorders by Kitani, Kenichi

“…In the present study, past attempts using different pharmaceuticals and chemicals which were reported to prolong lifespans of animals are critically reviewed…”
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Interventions in Aging and Age-Associated Pathologies by Means of Nutritional Approaches by KITANI, KENICHI, YOKOZAWA, TAKAKO, OSAWA, TOSHIHIKO

“…: So‐called antioxidant strategies have not been shown convincingly to be effective in increasing life spans of animals. Thus, the general consensus of…”
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Why (−)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects by Kitani, Kenichi, Minami, Chiyoko, Isobe, Ken-ichi, Maehara, Kayoko, Kanai, Setsuko, Ivy, Gwen O., Carrillo, Maria-Christina

“…(−)Deprenyl, a monoamine oxidase B (MAO B) inhibitor is known to upregulate activities of anti-oxidant enzymes such as superoxide dismutase (SOD) and catalase…”
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Mechanism underlying anti-apoptotic activity of a (−)deprenyl-related propargylamine, rasagiline by Maruyama, Wakako, Yamamoto, Takako, Kitani, Kenichi, Carrillo, Maria Christina, Youdim, Moussa, Naoi, Makoto

“…A potent inhibitor of type B monoamine oxidase, (−)deprenyl, is known to protect or rescue dying neurons, independent of inhibition of the enzyme activity…”
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Hyperoxia Induces the Differentiated Neuronal Phenotype of PC12 Cells by Producing Reactive Oxygen Species by Katoh, Shinsuke, Mitsui, Youji, Kitani, Kenichi, Suzuki, Takahiko

“…Neurite extension of PC12 cells induced by nerve growth factor (NGF) is a well-known model of neuronal differentiation. In this study, the incubation of PC12…”
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Effects of sanguiin H-6, a component of Sanguisorbae Radix, on lipopolysaccharide-stimulated nitric oxide production by Yokozawa, Takako, Chen, Cui Ping, Tanaka, Takashi, Kitani, Kenichi

“…The present study was conducted to evaluate the effect of sanguiin H-6, a component of Sanguisorbae Radix, on the production of nitric oxide (NO), using…”
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Hyperoxia induces the neuronal differentiated phenotype of PC12 cells via a sustained activity of mitogen-activated protein kinase induced by Bcl-2 by Katoh, S, Mitsui, Y, Kitani, K, Suzuki, T

“…We previously reported that rat pheochromocytoma PC12 cells express the neuronal differentiated phenotype under hyperoxia through the production of reactive…”
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Age-related changes in antioxidant enzyme activities in the brain and liver of BN/Bi rats: Striking differences from those in F344 rats emphasize the need for "public observations" for generating a general theory of aging by Carrillo, Maria-Cristina, Kitani, Kenichi, Minami, Chiyoko, Maruyama, Wakako

“…Objective:  Age‐related changes in endogenous antioxidant enzyme activities have been widely discussed in relation to mechanisms of organismic aging. However,…”
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Studies on aging in the 21st century--interventions in physiological aging by Kitani, Kenichi

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Hepatic injury induced by bile salts: correlation between biochemical and morphological events by Schmucker, D L, Ohta, M, Kanai, S, Sato, Y, Kitani, K

“…Continuous intravenous infusion of taurochenodeoxycholate at a rate of 0.4 mumol.min-1.100 gm-1 for only 30 min in rats caused threefold to tenfold greater…”
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Nerve Growth Factor Rescues PC12 Cells from Apoptosis by Increasing Amount of bcl-2 by Katoh, Shinsuke, Mitsui, Youji, Kitani, Kenichi, Suzuki, Takahiko

“…Nerve growth factor (NGF) suppressed the decrease in number of viable PC12 cells after serum withdrawal from culture medium. Accordingly, the amount of bcl-2,…”
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Potential of sanguiin H-6 against oxidative damage in renal mitochondria and apoptosis mediated by peroxynitrite in vivo by Yokozawa, Takako, Chen, Cui Ping, Rhyu, Dong Young, Tanaka, Takashi, Park, Jong Cheol, Kitani, Kenichi

“…Potential of sanguiin H-6, a component of Sanguisorbae Radix, to protect against oxidative damage in renal mitochondria and apoptosis mediated by peroxynitrite…”
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Age-related changes in antioxidant enzyme activities are region and organ, as well as sex, selective in the rat by Carrillo, M C, Kanai, S, Sato, Y, Kitani, K

“…Enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were determined in the liver as well as several specific…”
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Beneficial Effects of Sanguisorbae Radix in Renal Dysfunction Caused by Endotoxin in Vivo by CHEN, Cui Ping, YOKOZAWA, Takako, KITANI, Kenichi

“…The effect of Sanguisorbae Radix extract, a traditional crude drug, was investigated in renal dysfunction induced by lipopolysaccharide (LPS) endotoxin…”
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Hyperoxia induces the neuronal differentiated phenotype of PC12 cells via a sustained activity of mitogen-activated protein kinase induced by Bcl-2 by KATOH, Shinsuke, MITSUI, Youji, KITANI, Kenichi, SUZUKI, Takahiko

“…We previously reported that rat pheochromocytoma PC12 cells express the neuronal differentiated phenotype under hyperoxia through the production of reactive…”
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A Study on the Nitric Oxide Production-Suppressing Activity of Sanguisorbae Radix Components by YOKOZAWA, Takako, CHEN, Cui Ping, TANAKA, Takashi, KITANI, Kenichi

“…The active components of an aqueous extract of Sanguisorbae Radix, which possesses nitric oxide (NO) production-suppressing activity, were determined using…”
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Do Antioxidant Strategies Work against Aging and Age-associated Disorders? by Kitani, Kenichi, Minami, Chiyoko, Yamamoto, Takako, Maruyama, Wakako, Kanai, Setsuko, Ivy, Gwen O., Carrillo, Maria-Cristina

“…: The free radical theory of aging was initially proposed by Harman1 half a century ago primarily to explain biological aging processes. Although…”
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What really declines with age? The Hayflick Lecture for 2006 35th American Aging Association by Kitani, Kenichi

“…In order to understand the basic mechanisms underlying the organismic aging process, considerable efforts have been devoted in the last half-century to…”
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