Search Results - "Kitamoto, Junko"
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Abnormal Phagocytosis by Retinal Pigmented Epithelium That Lacks Myosin VIIa, the Usher Syndrome 1B Protein
Published in Proceedings of the National Academy of Sciences - PNAS (27-05-2003)“…Mutations in the myosin VIIa gene (MYO7A) cause Usher syndrome type 1B (USH1B), a major type of the deaf-blind disorder, Usher syndrome. We have studied mutant…”
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Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes
Published in Journal of cell science (15-12-2004)“…Myosin VIIa functions in the outer retina, and loss of this function causes human blindness in Usher syndrome type 1B (USH1B). In mice with mutant Myo7a,…”
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Two visual pigments in a single photoreceptor cell: identification and histological localization of three mRNAs encoding visual pigment opsins in the retina of the butterfly Papilio xuthus
Published in Journal of experimental biology (01-05-1998)“…This paper describes the localization of newly identified visual pigment opsins in the tiered retina of the Japanese yellow swallowtail Papilio xuthus. We…”
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Ultraviolet and violet receptors express identical mRNA encoding an ultraviolet-absorbing opsin: identification and histological localization of two mRNAs encoding short-wavelength-absorbing opsins in the retina of the butterfly Papilio xuthus
Published in Journal of experimental biology (01-10-2000)“…This paper describes the primary structures of two opsins of short-wavelength-absorbing visual pigments deduced from the mRNA sequences in the retina of the…”
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Temporal regulation of global gene expression and cellular morphology in Xenopus kidney cells in response to clinorotation
Published in Advances in space research (2005)“…Here, we report changes gene expression and morphology of the renal epithelial cell line, A6, which was derived from Xenopus laevis adult kidney that had been…”
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Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea
Published in Neuroscience letters (08-10-2015)“…•We identified 77 kinds of metabolites in inner ear fluid by metabolome analysis.•Six metabolites were more abundant in inner ear fluid than in plasma.•Nine…”
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Global and temporal regulation of gene expression in Xenopus kidney cells in response to presumed microgravity generated by 3D clinostats
Published in Uchū seibutsu kagaku (01-11-2004)“…We documented changes in morphology and gene expression of the renal epithelial cell line A6 derived from Xenopus leavis adult kidney induced by long-term…”
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Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA combined with cisplatin inhibits cellular growth and induces apoptosis in HPV-positive head and neck cancer cells
Published in Cancer gene therapy (01-10-2018)“…Human papillomavirus (HPV) infection has been identified as an etiologic factor of head and neck cancers (HNCs). We explored the potential use of antisense HPV…”
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SDF-1α regulates mesendodermal cell migration during frog gastrulation
Published in Biochemical and biophysical research communications (09-03-2007)“…During frog gastrulation, mesendodermal cells become apposed to the blastocoel roof (BCR) by endoderm rotation, and migrate towards the animal pole. The…”
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Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention against head and neck cancer-containing HPV16 cell lines
Published in Acta oto-laryngologica (01-07-2013)“…Abstract Conclusion: Our results indicate that siRNA E6 and/or E7 may have potential as a gene-specific therapy for human papillomavirus (HPV) type 16…”
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The expression of Wnt2b in the optic cup lip requires a border between the pigmented and nonpigmented epithelium
Published in Molecular vision (14-12-2010)“…Wnt2b is normally expressed at the optic cup lip and is implicated in ciliary body induction. The lens has often been considered an organizer for the anterior…”
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Oncolytic effect of Midkine promoter–based conditionally replicating adenoviruses expressing EGFR siRNA in head and neck squamous cancer cell line T891
Published in Cancer reports (01-06-2020)“…Background Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinomas (HNSCCs). Midkine expression is restricted in…”
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Myosin Va is required for normal photoreceptor synaptic activity
Published in Journal of cell science (01-09-2004)“…Myosin Va is an actin-based motor molecule, one of a large family of unconventional myosins. In humans, mutations in MYO5A cause Griscelli syndrome type 1 and…”
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Roles and interactions of usher 1 proteins in the outer retina
Published in Advances in experimental medicine and biology (2006)“…Our studies demonstrate that harmonin and myosin VIIa are not localized in the same compartments in the mouse and human retinas, indicating that they do not…”
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Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration
Published in Experimental eye research (01-12-2003)“…Mutations in the cadherin 23 gene ( CDH23) cause Usher syndrome type 1D in humans, a disease that results in retinitis pigmentosa and deafness. Cdh23 is also…”
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Mouse models for Usher syndrome 1B
Published in Advances in experimental medicine and biology (2003)“…Photoreceptor cell degeneration was not detected in any of the shaker1 alleles, except for a small but significant loss of photoreceptor cells found in…”
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Myosin VI is required for normal retinal function
Published in Experimental eye research (01-07-2005)“…Different unconventional myosins have been shown to play important roles in sensory function, including vision. We investigated the role of myosin VI by…”
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Serum and tissue metabolomics of head and neck cancer
Published in Cancer genomics & proteomics (01-09-2013)“…No reliable clinical markers to diagnose early stage-disease and predict its prognosis have yet been found for squamous cell carcinoma of the head and neck…”
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Role of myosin V IIa and Rab27a in the motility and localization of RPE melanosomes
Published in Journal of cell science (15-12-2004)“…Myosin V IIa functions in the outer retina, and loss of this function causes human blindness in Usher syndrome type 1B (USH1B). In mice with mutant Myo7a,…”
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