Search Results - "Kitajima, Mariko"
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Recent studies on chemical constituents of Ophiorrhiza plants
Published in Journal of natural medicines (01-09-2022)“…Ophiorrhiza plants (Family Rubiaceae) are known to produce diverse monoterpenoid indole alkaloids including camptothecin with potent antitumor activity. This…”
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Enantioselective Total Syntheses of (−)-Silicine and (−)-20-Episilicine
Published in Organic letters (27-10-2023)“…The enantioselective total syntheses of (−)-silicine and (−)-20-episilicine, which contain a chiral piperidine with three contiguous chiral centers (D-ring)…”
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Total Syntheses of (+)‐Villocarine A, (−)‐Apogeissoschizine, and (+)‐Geissoschizine
Published in Chemistry : a European journal (28-03-2023)“…Total syntheses of geissoschizine‐type monoterpenoid indole alkaloids (MTIAs) are reported. An intramolecular Pictet‐Spengler cyclization was developed for the…”
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Total Syntheses of Pleiocarpamine, Normavacurine, and C‑Mavacurine
Published in Organic letters (03-05-2019)“…The total syntheses of C-mavacurine-type indole alkaloids, (±)-pleiocarpamine, (±)-normavacurine, and (±)-C-mavacurine, were accomplished. The key step in the…”
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Cover Feature: Total Syntheses of (+)‐Villocarine A, (−)‐Apogeissoschizine, and (+)‐Geissoschizine (Chem. Eur. J. 18/2023)
Published in Chemistry : a European journal (28-03-2023)“…Geissoschizine is a very important biosynthetic intermediate of monoterpenoid alkaloids in higher plants. In this study, the enantioselective and…”
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Asymmetric Total Syntheses of Mitragynine, Speciogynine, and 7-Hydroxymitragynine
Published in Chemical & pharmaceutical bulletin (01-09-2022)“…A number of alkaloids found in Mitragyna species belonging to the Rubiaceae family have been shown to have potent biological activity such as analgesic…”
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Asymmetric Total Synthesis of Fawcettimine-Type Lycopodium Alkaloid, Lycopoclavamine‑A
Published in Journal of organic chemistry (03-05-2019)“…An asymmetric total synthesis of lycopoclavamine-A (1), a structurally unique fawcettimine-type Lycopodium alkaloid, was achieved via a stereoselective…”
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Bioinspired Total Synthesis of (+)-Kopsiyunnanine B
Published in Chemical & pharmaceutical bulletin (01-01-2024)“…The first enantioselective total synthesis of kopsiyunnanine B, which has a unique folded and complex pentacyclic structure containing six contiguous chiral…”
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Asymmetric Total Synthesis of a Pentacyclic Lycopodium Alkaloid: Huperzine-Q
Published in Angewandte Chemie International Edition (22-08-2011)“…Right on Q: The first asymmetric total synthesis of (−)‐huperzine‐Q, which possesses six stereogenic centers and a spiroaminal moiety, has been achieved in 19…”
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Asymmetric Total Synthesis of Sarpagine-Related Indole Alkaloids Hydroxygardnerine, Hydroxygardnutine, Gardnerine, (E)‑16-epi-Normacusine B, and Koumine
Published in Organic letters (15-04-2016)“…Sarpagine-related indole alkaloids (−)-hydroxygardnerine, (+)-hydroxygardnutine, (−)-gardnerine, (+)-(E)-16-epi-normacusine B, and (−)-koumine were divergently…”
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Asymmetric Total Synthesis and Evaluation of Antitumor Activity of Ophiorrhisine A and Its Derivatives
Published in Journal of organic chemistry (21-12-2018)“…The first asymmetric total synthesis of ophiorrhisine A (1), a new cyclic tetrapeptide isolated from Ophiorrhiza nutans, was accomplished via an intramolecular…”
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Asymmetric Total Synthesis and Structure Elucidation of Huperzine H
Published in Journal of organic chemistry (04-03-2022)“…A first asymmetric total synthesis of huperzine H has been achieved in a 12% overall yield from commercially available (+)-pulegone. The key steps of this…”
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Biogenetically Inspired Total Syntheses of Lycopodium Alkaloids, (+)-Flabellidine and (−)-Lycodine
Published in Journal of the American Chemical Society (20-08-2014)“…The first asymmetric total synthesis of (+)-flabellidine (2) and the shortest total synthesis of (−)-lycodine (3) were accomplished by a strategy featuring the…”
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flavonoid 3‐O‐glucoside:2″‐O‐glucosyltransferase responsible for terminal modification of pollen‐specific flavonols in Arabidopsis thaliana
Published in The Plant journal : for cell and molecular biology (01-09-2014)“…Flavonol 3‐O‐diglucosides with a 1→2 inter‐glycosidic linkage are representative pollen‐specific flavonols that are widely distributed in plants, but their…”
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Concise asymmetric total synthesis of lycopodine and flabelliformine via cascade cyclization reaction
Published in Tetrahedron letters (10-01-2019)“…[Display omitted] •The shortest-step asymmetric total synthesis of lycopodine was accomplished.•The first asymmetric synthesis of flabelliformine was…”
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Total synthesis of conolidine and apparicine
Published in Tetrahedron letters (20-01-2016)“…[Display omitted] A total synthesis of indole alkaloids, (±)-conolidine and (±)-apparicine, was accomplished via a gold(I)-catalyzed 6-exo-dig cyclization to…”
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Asymmetric Total Synthesis of Pentacyclic Indole Alkaloid Andranginine and Absolute Configuration of Natural Product Isolated from Kopsia arborea
Published in Organic letters (19-05-2017)“…The first asymmetric total synthesis of andranginine (1) via an asymmetric Morita–Baylis–Hillman reaction and a diastereoselective intramolecular Diels–Alder…”
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Synthetic study of biphenylquinolizidine alkaloids I. Asymmetric total synthesis of lasubine I featuring organocatalyzed asymmetric intramolecular aza-Michael addition
Published in Tetrahedron letters (2017)“…[Display omitted] •An organocatalyzed asymmetric intramolecular aza-Michael addition of linear dienone was developed.•A new synthetic method of chiral…”
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Asymmetric Total Synthesis of Biphenylquinolizidine Alkaloids 4″‑O‑Demethyllythridine and 14-epi-4″‑O‑Demethyllythridine
Published in Organic letters (04-10-2019)“…The first asymmetric total synthesis of new biphenylquinolizidine alkaloids 4″-O-demethyllythridine and 14-epi-4″-O-demethyllythridine isolated from Heimia…”
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New Lycopodine-Type Alkaloids from Lycopodium carinatum
Published in Chemical & pharmaceutical bulletin (01-07-2016)“…The structures of new lycopodine-type alkaloids, lycopocarinamines A–F, which were isolated from Lycopodium carinatum, were elucidated by spectroscopic…”
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