Search Results - "Kitajewski, Jan K."

Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair by Finn, Johanna, Sottoriva, Kilian, Pajcini, Kostandin V., Kitajewski, Jan K., Chen, Chang, Zhang, Wei, Malik, Asrar B., Liu, Yuru

“…Lung alveolar type I cells (AT1) and alveolar type II cells (AT2) regulate the structural integrity and function of alveoli. AT1, covering ∼95% of the surface…”
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A new paradigm for the role of smooth muscle cells in the human cervix by Vink, Joy Y., MD, Qin, Sisi, PhD, Brock, Clifton O., MD, Zork, Noelia M., MD, Feltovich, Helen M., MD, Chen, Xiaowei, MD, Urie, Paul, MD, Myers, Kristin M., PhD, Hall, Timothy J., PhD, Wapner, Ronald, MD, Kitajewski, Jan K., PhD, Shawber, Carrie J., PhD, Gallos, George, MD

“…Background Premature cervical remodeling resulting in spontaneous preterm birth may begin with premature failure or relaxation at the internal os (termed…”
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CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function by Mao, De Yu, Kleinjan, Matthew L, Jilishitz, Irina, Swaminathan, Bhairavi, Obinata, Hideru, Komarova, Yulia A, Bayless, Kayla J, Hla, Timothy, Kitajewski, Jan K

“…Chloride intracellular channels 1 (CLIC1) and 4 (CLIC4) are expressed in endothelial cells and regulate angiogenic behaviors in vitro, and the expression of is…”
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Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling by Balaji Ragunathrao, Vijay Avin, Anwar, Mumtaz, Akhter, Md Zahid, Chavez, Alejandra, Mao, De Yu, Natarajan, Viswanathan, Lakshmikanthan, Sribalaji, Chrzanowska-Wodnicka, Magdalena, Dudek, Arkadiusz Z., Claesson-Welsh, Lena, Kitajewski, Jan K., Wary, Kishore K., Malik, Asrar B., Mehta, Dolly

“…The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor vascularization by activating proangiogenic signaling in endothelial cells (ECs)…”
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Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migration by Perlman, Barry E, Merriam, Audrey A, Lemenze, Alexander, Zhao, Qingshi, Begum, Salma, Nair, Mohan, Wu, Tracy, Wapner, Ronald J, Kitajewski, Jan K, Shawber, Carrie J, Douglas, Nataki C

“…In the first trimester of human pregnancy, low oxygen tension or hypoxia is essential for proper placentation and placenta function. Low oxygen levels and…”
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Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration by Swaminathan, Bhairavi, Youn, Seock-Won, Naiche, L. A., Du, Jing, Villa, Stephanie R., Metz, Jordan B., Feng, Huijuan, Zhang, Chaolin, Kopan, Raphael, Sims, Peter A., Kitajewski, Jan K.

“…To control sprouting angiogenesis, endothelial Notch signaling suppresses tip cell formation, migration, and proliferation while promoting barrier formation…”
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Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model by Price, Jessica C, Azizi, Elham, Naiche, L A, Parvani, Jenny G, Shukla, Priyanka, Kim, Seoyeon, Slack-Davis, Jill K, Pe'er, Dana, Kitajewski, Jan K

“…High grade serous ovarian cancer (HGSC) is the most common and deadly type of ovarian cancer, largely due to difficulties in early diagnosis and rapid…”
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Endothelial Jagged1 Antagonizes Dll4/Notch Signaling in Decidual Angiogenesis during Early Mouse Pregnancy by Marchetto, Nicole M, Begum, Salma, Wu, Tracy, O'Besso, Valerie, Yarborough, Christina C, Valero-Pacheco, Nuriban, Beaulieu, Aimee M, Kitajewski, Jan K, Shawber, Carrie J, Douglas, Nataki C

“…Maternal spiral arteries and newly formed decidual capillaries support embryonic development prior to placentation. Previous studies demonstrated that Notch…”
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Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity by Reeves, Claire V, Wang, Xing, Charles-Horvath, Pelisa C, Vink, Joy Y, Borisenko, Valeriya Y, Young, John A T, Kitajewski, Jan K

“…Anthrax Toxin Receptor proteins function as receptors for anthrax toxin, however physiological activity remains unclear. To evaluate the biological role of…”
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Dynamic maternal and fetal Notch activity and expression in placentation by Levin, Heather I, Sullivan-Pyke, Chantae S, Papaioannou, Virginia E, Wapner, Ronald J, Kitajewski, Jan K, Shawber, Carrie J, Douglas, Nataki C., M.D., PhD

“…Abstract Introduction Murine placentation requires trophoblast Notch2, while the Notch ligand, JAGGED1, is reduced in invasive trophoblasts from women with…”
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Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation by Shawber, Carrie J, Brown-Grant, Dex-Ann, Wu, Tracy, Kitajewski, Jan K, Douglas, Nataki C

“…Proper development and function of the mammalian placenta requires interactions between embryo-derived trophoblasts and uterine endothelial cells to form…”
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Endothelial Cell Fate Determination: A Top Notch Job in Vascular Decision-Making by Naiche, L A, Villa, Stephanie R, Kitajewski, Jan K

“…As vascular networks form, endothelial cells (ECs) undergo cell fate decisions that determine whether they become tip or stalk cells of the developing vascular…”
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Notch transcriptional target tmtc1 maintains vascular homeostasis by Paik, Na Yoon, Neethling, Jacob, Anwar, Mumtaz, Gupta, Prerak, Sanborn, Mark A., Shen, Zekun, Bandara, Thilinie, Hyun, James, Naiche, L. A., Kitajewski, Jan K., Rehman, Jalees, Shin, Jae-Won, Mehta, Dolly, Pajcini, Kostandin V.

“…Proper lung function requires the maintenance of a tight endothelial barrier while simultaneously permitting the exchange of macromolecules and fluids to…”
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Notch ligands are biomarkers of anti-TNF response in RA patients by Zack, Stephanie R., Meyer, Anja, Zanotti, Brian, Volin, Michael V., Deen, Sania, Satoeya, Neha, Sweiss, Nadera, Lewis, Myles J., Pitzalis, Costantino, Kitajewski, Jan K., Shahrara, Shiva

“…Notch and its ligands play a critical role in rheumatoid arthritis (RA) pathogenesis. Hence, studies were conducted to delineate the functional significance of…”
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Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties by Sargis, Timothy, Youn, Seock-Won, Thakkar, Krishna, Naiche, L. A., Paik, Na Yoon, Pajcini, Kostandin V., Kitajewski, Jan K.

“…The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific…”
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Propranolol Accelerates Adipogenesis in Hemangioma Stem Cells and Causes Apoptosis of Hemangioma Endothelial Cells by Wong, Alvin, Hardy, Krista L., Kitajewski, Alex M., Shawber, Carrie J., Kitajewski, Jan K., Wu, June K.

“…Infantile hemangiomas can cause significant morbidity during proliferation, yet there is no U.S. Food and Drug Administration-approved treatment. They are…”
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Neuroblastoma differentiation in vivo excludes cranial tumors by Treffy, Randall W., Rajan, Sriivatsan G., Jiang, Xinghang, Nacke, Lynne M., Malkana, Usama A., Naiche, L.A., Bergey, Dani E., Santana, Dianicha, Rajagopalan, Vinodh, Kitajewski, Jan K., O’Bryan, John P., Saxena, Ankur

“…Neuroblastoma (NB), the most common cancer in the first year of life, presents almost exclusively in the trunk. To understand why an early-onset cancer would…”
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Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking by Gross, Stephen J., Webb, Amelia M., Peterlin, Alek D., Durrant, Jessica R., Judson, Rachel J., Raza, Qanber, Kitajewski, Jan K., Kushner, Erich J.

“…Collagen type IV (Col IV) is a basement membrane protein associated with early blood vessel morphogenesis and is essential for blood vessel stability. Defects…”
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Three-dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart by Phillips, Evan H, Bindokas, Vytautas P, Jung, Dahee, Teamer, Jay, Kitajewski, Jan K, Solaro, R John, Wolska, Beata M, Lee, Steve Seung-Young

“…Three-dimensional (3D) microscopy and image data analysis are necessary for studying the morphology of cardiac lymphatic vessels (LyVs) and their association…”
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Notch suppresses angiogenesis and progression of hepatic metastases by Banerjee, Debarshi, Hernandez, Sonia L, Garcia, Alejandro, Kangsamaksin, Thaned, Sbiroli, Emily, Andrews, John, Forrester, Lynn Ann, Wei, Na, Kadenhe-Chiweshe, Angela, Shawber, Carrie J, Kitajewski, Jan K, Kandel, Jessica J, Yamashiro, Darrell J

“…The Notch pathway plays multiple key roles in tumorigenesis, and its signaling components have therefore aroused great interest as targets for emerging…”
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